2022
Performance of Xpert MTB/RIF and Mycobacterial Culture on Multiple Specimen Types for Diagnosis of Tuberculosis Disease in Young Children and Clinical Characterization According to Standardized Research Case Definitions
Click ES, Song R, Smith JP, Mchembere W, Fajans M, Hariri P, Okeyo E, McCarthy KD, Gethi D, Odeny L, Musau S, Okumu A, Orwa J, Perez-Velez CM, Wright CA, Andres M, Marais BJ, Schaaf HS, Graham SM, Cruz AT, Cain KP. Performance of Xpert MTB/RIF and Mycobacterial Culture on Multiple Specimen Types for Diagnosis of Tuberculosis Disease in Young Children and Clinical Characterization According to Standardized Research Case Definitions. The Pediatric Infectious Disease Journal 2022, 41: 671-677. PMID: 35703284, PMCID: PMC9288526, DOI: 10.1097/inf.0000000000003582.Peer-Reviewed Original ResearchConceptsXpert MTB/RIFResearch case definitionClinical case definitionMTB/RIFCase definitionIntrathoracic tuberculosisClinical characterizationMycobacterial cultureYoung childrenProspective cohort studyDifferent specimen typesDetailed clinical characterizationMultiple specimen typesSpecimen typesClinical diagnostic approachTB diseaseCohort studyMycobacterium tuberculosis complexParenchymal abnormalitiesConsecutive seriesOutpatient settingTuberculosis diseaseLeading causeXpert testChest radiographsTuberculosis attributed to transmission within healthcare facilities, Botswana—The Kopanyo Study
Smith JP, Modongo C, Moonan PK, Dima M, Matsiri O, Fane O, Click ES, Boyd R, Finlay A, Surie D, Tobias JL, Zetola NM, Oeltmann JE. Tuberculosis attributed to transmission within healthcare facilities, Botswana—The Kopanyo Study. Infection Control And Hospital Epidemiology 2022, 43: 1603-1609. PMID: 35382909, PMCID: PMC9535034, DOI: 10.1017/ice.2021.517.Peer-Reviewed Original ResearchConceptsElectronic medical recordsHealthcare facilitiesPopulation-based molecular epidemiologic studyMolecular epidemiologic studiesTB casesTB diagnosisTB transmissionTB epidemicMedical recordsTuberculosis diseaseBiologic plausibilityHealthcare workersIndividual patientsEpidemiologic studiesGeneral populationCommunity transmissionEtiologic agentTreatment dataClinical encountersPatientsEffective interventionsIndividual riskEMR dataTransmission eventsHigh-risk environments
2013
Aspiring to Zero Tuberculosis Deaths among Southern Africa's Miners: Is There a Way Forward?
Dharmadhikari A, Smith J, Nardell E, Churchyard G, Keshavjee S. Aspiring to Zero Tuberculosis Deaths among Southern Africa's Miners: Is There a Way Forward? International Journal Of Social Determinants Of Health And Health Services 2013, 43: 651-664. PMID: 24397232, DOI: 10.2190/hs.43.4.d.Peer-Reviewed Original ResearchMeSH KeywordsAfrica, SouthernComorbidityDisease ProgressionEarly DiagnosisHIV InfectionsHousingHumansImmunocompromised HostLatent TuberculosisMaleMiningOccupational DiseasesOccupational Health ServicesSecondary PreventionSilicosisSocial ConditionsTuberculosisTuberculosis, Multidrug-ResistantWorkforceConceptsTuberculosis notification ratesNotification ratesDrug-resistant strainsSpread of tuberculosisHigh rateTuberculosis deathsActive tuberculosisHIV infectionSouth African minersImmediate treatmentTuberculosis diseaseConcurrent treatmentTuberculosis mortalityGeneral populationAppropriate managementTuberculosisSilica dustActive casesBiomedical interventionsDiseaseDeathAirborne diseasesInfectionPoor workingAfrican miners