Clinical and Radiologic Factors Associated With Detection of Mycobacterium tuberculosis in Children Under 5 Years old Using Invasive and Noninvasive Sample Collection Techniques—Kenya
Smith J, Song R, McCarthy K, Mchembere W, Click E, Cain K. Clinical and Radiologic Factors Associated With Detection of Mycobacterium tuberculosis in Children Under 5 Years old Using Invasive and Noninvasive Sample Collection Techniques—Kenya. Open Forum Infectious Diseases 2022, 9: ofac560. PMID: 36386048, PMCID: PMC9664973, DOI: 10.1093/ofid/ofac560.Peer-Reviewed Original ResearchSpecimen collection techniquesRadiologic factorsYoung childrenProspective cohort studyFine-needle aspirationHistory of exposurePublic health concernCritical public health concernBacteriologic confirmationAirway compressionCervical lymphadenopathyRadiological factorsCohort studyPediatric tuberculosisTB casesPresumptive tuberculosisClinical managementImmunologic evidenceNeedle aspirationPositive specimenDiagnostic testingTuberculosisLogistic regressionHealth concernMycobacterium tuberculosisTuberculosis attributed to transmission within healthcare facilities, Botswana—The Kopanyo Study
Smith JP, Modongo C, Moonan PK, Dima M, Matsiri O, Fane O, Click ES, Boyd R, Finlay A, Surie D, Tobias JL, Zetola NM, Oeltmann JE. Tuberculosis attributed to transmission within healthcare facilities, Botswana—The Kopanyo Study. Infection Control And Hospital Epidemiology 2022, 43: 1603-1609. PMID: 35382909, PMCID: PMC9535034, DOI: 10.1017/ice.2021.517.Peer-Reviewed Original ResearchConceptsElectronic medical recordsHealthcare facilitiesPopulation-based molecular epidemiologic studyMolecular epidemiologic studiesTB casesTB diagnosisTB transmissionTB epidemicMedical recordsTuberculosis diseaseBiologic plausibilityHealthcare workersIndividual patientsEpidemiologic studiesGeneral populationCommunity transmissionEtiologic agentTreatment dataClinical encountersPatientsEffective interventionsIndividual riskEMR dataTransmission eventsHigh-risk environmentsModel-based Analysis of Tuberculosis Genotype Clusters in the United States Reveals High Degree of Heterogeneity in Transmission and State-level Differences Across California, Florida, New York, and Texas
Shrestha S, Winglee K, Hill A, Shaw T, Smith J, Kammerer JS, Silk BJ, Marks S, Dowdy D. Model-based Analysis of Tuberculosis Genotype Clusters in the United States Reveals High Degree of Heterogeneity in Transmission and State-level Differences Across California, Florida, New York, and Texas. Clinical Infectious Diseases 2022, 75: 1433-1441. PMID: 35143641, PMCID: PMC9412192, DOI: 10.1093/cid/ciac121.Peer-Reviewed Original ResearchConceptsTB casesTB transmissionKey public health priorityPublic health priorityMechanistic transmission modelsTB incidenceTuberculosis transmissionSecondary casesHealth priorityInfectious casesTransmission clustersDisease controlMean numberR0 estimatesUnited StatesWhole-genome sequencingSame countyGenotype clustersState-level differencesSecondary transmissionCasesIncidence