Incorporating Biological Pathways via a Markov Random Field Model in Genome-Wide Association Studies
Chen M, Cho J, Zhao H. Incorporating Biological Pathways via a Markov Random Field Model in Genome-Wide Association Studies. PLOS Genetics 2011, 7: e1001353. PMID: 21490723, PMCID: PMC3072362, DOI: 10.1371/journal.pgen.1001353.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesAssociation studiesBiological pathwaysSingle gene-based methodsMarkov random field modelGene-based methodsPrior biological knowledgeRandom field modelGWAS analysisAssociation signalsMultiple genesPathway topologyGene associationsAssociation analysisGenesBiological knowledgeField modelGenetic variantsSpecific pathwaysReal data examplePathwayStatistical inferenceConditional modes algorithmExchangeable setRegression form
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply