2021
Costs and impact on HIV transmission of a switch from a criminalisation to a public health approach to injecting drug use in eastern Europe and central Asia: a modelling analysis
Ward Z, Stone J, Bishop C, Ivakin V, Eritsyan K, Deryabina A, Low A, Cepeda J, Kelly SL, Heimer R, Cook R, Altice FL, Litz T, Terlikbayeva A, El-Bassel N, Havarkov D, Fisenka A, Boshnakova A, Klepikov A, Saliuk T, Deshko T, Vickerman P. Costs and impact on HIV transmission of a switch from a criminalisation to a public health approach to injecting drug use in eastern Europe and central Asia: a modelling analysis. The Lancet HIV 2021, 9: e42-e53. PMID: 34895484, PMCID: PMC8762142, DOI: 10.1016/s2352-3018(21)00274-5.Peer-Reviewed Original ResearchConceptsOpioid agonist therapyAgonist therapyAntiretroviral therapyPublic health approachHIV transmissionDrug useDynamic HIV transmission modelHealth approachIncremental cost-effectiveness ratioHIV transmission modelNational InstituteCost-effectiveness ratioCountry-specific costsHIV incidenceUNAIDS 90US National InstitutesART coverageWHO targetPWIDTherapyPay thresholdsInfectious diseasesCost savingsDrug abuseIncremental costModelling the intervention effect of opioid agonist treatment on multiple mortality outcomes in people who inject drugs: a three-setting analysis
Stone J, Degenhardt L, Grebely J, Larney S, Altice FL, Smyrnov P, Rahimi-Movaghar A, Alavi M, Young AM, Havens JR, Miller WC, Hickman M, Vickerman P. Modelling the intervention effect of opioid agonist treatment on multiple mortality outcomes in people who inject drugs: a three-setting analysis. The Lancet Psychiatry 2021, 8: 301-309. PMID: 33640039, PMCID: PMC8255389, DOI: 10.1016/s2215-0366(20)30538-1.Peer-Reviewed Original ResearchConceptsOpioid agonist treatmentDrug-related deathsOAT coverageDrug-related harmAgonist treatmentHepatitis C virus transmissionC virus transmissionOverall health benefitsUK National InstituteNational InstituteHIV 0OAT retentionHIV mortalityInjury 3Opioid dependenceMortality outcomesUS National InstitutesHCV-2Overdose deathsSignificant additional effectIntervention effectsDrug abuseHealth benefitsMortalityDeath
2018
Incarceration history and risk of HIV and hepatitis C virus acquisition among people who inject drugs: a systematic review and meta-analysis
Stone J, Fraser H, Lim AG, Walker JG, Ward Z, MacGregor L, Trickey A, Abbott S, Strathdee SA, Abramovitz D, Maher L, Iversen J, Bruneau J, Zang G, Garfein RS, Yen YF, Azim T, Mehta SH, Milloy MJ, Hellard ME, Sacks-Davis R, Dietze PM, Aitken C, Aladashvili M, Tsertsvadze T, Mravčík V, Alary M, Roy E, Smyrnov P, Sazonova Y, Young AM, Havens JR, Hope VD, Desai M, Heinsbroek E, Hutchinson SJ, Palmateer NE, McAuley A, Platt L, Martin NK, Altice FL, Hickman M, Vickerman P. Incarceration history and risk of HIV and hepatitis C virus acquisition among people who inject drugs: a systematic review and meta-analysis. The Lancet Infectious Diseases 2018, 18: 1397-1409. PMID: 30385157, PMCID: PMC6280039, DOI: 10.1016/s1473-3099(18)30469-9.Peer-Reviewed Original ResearchConceptsHCV acquisition riskAcquisition riskHCV incidenceModerate heterogeneitySystematic reviewHepatitis C virus acquisitionHepatitis C virus infectionHIV acquisition riskRisk of HCVC virus infectionNewcastle-Ottawa ScaleRisk of biasRisk of HIVNational InstituteCommunity-recruited PWIDOutcomes of interestIncident infectionsCohort studyHIV acquisitionHIV transmissionHigh prevalenceVirus infectionRecent incarcerationExclusion criteriaHigh risk
2017
Hepatitis C virus treatment as prevention in an extended network of people who inject drugs in the USA: a modelling study
Zelenev A, Li J, Mazhnaya A, Basu S, Altice FL. Hepatitis C virus treatment as prevention in an extended network of people who inject drugs in the USA: a modelling study. The Lancet Infectious Diseases 2017, 18: 215-224. PMID: 29153265, PMCID: PMC5860640, DOI: 10.1016/s1473-3099(17)30676-x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAntiviral AgentsChemopreventionCitiesComputer SimulationDisease Transmission, InfectiousFemaleHepatitis CHumansMaleMiddle AgedModels, StatisticalPrevalenceSubstance Abuse, IntravenousSurveys and QuestionnairesTime FactorsTreatment OutcomeUnited StatesYoung AdultConceptsBaseline HCV prevalenceHepatitis C virusHCV prevalenceInjection partnersPrevention strategiesTreatment coverageTransmission of HCVHepatitis C virus (HCV) treatmentHCV elimination strategySuccessful HCV treatmentC virus treatmentInjection drug usersHCV treatment coverageAdditional network memberHCV treatmentActing antiviralsC virusChronic infectionVirus treatmentDrug usersPrevalenceDrug abuseDrugsNational InstitutePrevention
2016
Relapse to opioid use in opioid-dependent individuals released from compulsory drug detention centres compared with those from voluntary methadone treatment centres in Malaysia: a two-arm, prospective observational study
Wegman MP, Altice FL, Kaur S, Rajandaran V, Osornprasop S, Wilson D, Wilson DP, Kamarulzaman A. Relapse to opioid use in opioid-dependent individuals released from compulsory drug detention centres compared with those from voluntary methadone treatment centres in Malaysia: a two-arm, prospective observational study. The Lancet Global Health 2016, 5: e198-e207. PMID: 27964869, PMCID: PMC5657487, DOI: 10.1016/s2214-109x(16)30303-5.Peer-Reviewed Original ResearchConceptsVoluntary drug treatment centresCompulsory drug detention centersOpioid-dependent individualsProspective observational studyOpioid relapseTwo-armObservational studyTreatment centersEvidence-based pharmacological therapyHazard ratio reductionUrinary drug testingDrug testsOpioid agonist treatmentDoris Duke Charitable FoundationOpioid use disorderUrine drug testsMethadone treatment centersAssessed individualsDrug treatment centersNational InstituteEvidence-based treatmentsSubstance use disordersMedical Research CouncilAustralian National HealthVTC participants
2015
Effect of Ebola progression on transmission and control in Liberia.
Yamin D, Gertler S, Ndeffo-Mbah ML, Skrip LA, Fallah M, Nyenswah TG, Altice FL, Galvani AP. Effect of Ebola progression on transmission and control in Liberia. Annals Of Internal Medicine 2015, 162: 11-7. PMID: 25347321, PMCID: PMC4402942, DOI: 10.7326/m14-2255.Peer-Reviewed Original ResearchConceptsCase fatalityDisease progressionContacts of patientsEntire infectious periodDeadliest Ebola epidemicSingle infected caseStochastic transmission modelSymptom onsetIll patientsViral loadClinical dataSymptomatic phaseHigh riskSecondary infectionLiberian MinistryInfected individualsNonsurvivorsTargeted interventionsMontserrado CountyInfected casesEbola incidenceEbola epidemicInfectious periodNational InstituteProgression
2014
HIV in people reincarcerated in Connecticut prisons and jails: an observational cohort study
Meyer JP, Cepeda J, Springer SA, Wu J, Trestman RL, Altice FL. HIV in people reincarcerated in Connecticut prisons and jails: an observational cohort study. The Lancet HIV 2014, 1: e77-e84. PMID: 25473651, PMCID: PMC4249702, DOI: 10.1016/s2352-3018(14)70022-0.Peer-Reviewed Original ResearchViral suppressionHIV treatment outcomesInhibitor-based regimensObservational cohort studyHIV viral suppressionART regimenCohort studyRetrospective cohortPrimary outcomeViral loadPsychiatric comorbidityTreatment outcomesIdentification of individualsHIVJail detaineesLaboratory databaseTreatment potencyDrug abuseRNA copiesNational InstitutePrison releasePublic healthBlack menIncarceration periodsOutcomesDynamics and control of Ebola virus transmission in Montserrado, Liberia: a mathematical modelling analysis
Lewnard JA, Mbah M, Alfaro-Murillo JA, Altice FL, Bawo L, Nyenswah TG, Galvani AP. Dynamics and control of Ebola virus transmission in Montserrado, Liberia: a mathematical modelling analysis. The Lancet Infectious Diseases 2014, 14: 1189-1195. PMID: 25455986, PMCID: PMC4316822, DOI: 10.1016/s1473-3099(14)70995-8.Peer-Reviewed Original ResearchConceptsEVD casesCase ascertainmentTreatment centersCases of EVDEbola virus disease epidemicPrimary outcome measureEbola virus transmissionPublic health responseIntervention initiationUS National InstitutesOutcome measuresHealth responseNumber of bedsContact tracingMontserrado CountyEbola virusAdditional bedsBasic reproductive numberVirus transmissionAscertainmentNational InstituteInterventionEVDDeathMathematical modelling analysis
2011
HIV-Related Research in Correctional Populations: Now is the Time
Rich JD, Wohl DA, Beckwith CG, Spaulding AC, Lepp NE, Baillargeon J, Gardner A, Avery A, Altice FL, Springer S, On behalf of the Centers for AIDS Research—Collaboration on HIV in Corrections (CFAR-CHIC) Working Group. HIV-Related Research in Correctional Populations: Now is the Time. Current HIV/AIDS Reports 2011, 8: 288. PMID: 21904902, PMCID: PMC3208731, DOI: 10.1007/s11904-011-0095-3.Peer-Reviewed Original ResearchConceptsPrevention of HIVTransmission of HIVMental health disordersAcademic medical centerIllicit drug useEpidemic of incarcerationHIV-Related ResearchAntiretroviral therapyHIV infectionHIV transmissionMedical CenterHIVHealth disordersDrug useRisk behaviorsAIDS researchSubstance useSubstantial proportionNational InstituteRecent evidenceIncarcerated populationsPublic healthHealthCorrectional populationsPopulation
1995
Women living with substance abuse and HIV disease: medical care access issues.
Weissman G, Melchior L, Huba G, Altice F, Booth R, Cottler L, Genser S, Jones A, McCarthy S, Needle R. Women living with substance abuse and HIV disease: medical care access issues. Journal Of The American Medical Women's Association 1995, 50: 115-20. PMID: 7657944.Peer-Reviewed Original ResearchConceptsFirst positive HIV testHIV disease coursePositive HIV testHIV testing historyMedical servicesPost-test counselingMental health servicesDrug-using womenUse of healthHIV diseaseHIV testDisease courseDrug abusersTesting historyHealth servicesMen subjectsHealth resourcesSubstance abuseDrug abuseWomenMore womenFirst-year findingsServices AdministrationNational InstituteLongitudinal study