2020
Decreased sphingolipid synthesis in children with 17q21 asthma–risk genotypes
Ono JG, Kim BI, Zhao Y, Christos PJ, Tesfaigzi Y, Worgall TS, Worgall S. Decreased sphingolipid synthesis in children with 17q21 asthma–risk genotypes. Journal Of Clinical Investigation 2020, 130: 921-926. PMID: 31929190, PMCID: PMC6994114, DOI: 10.1172/jci130860.Peer-Reviewed Original ResearchConceptsSphingolipid de novo synthesisNonallergic asthmaPeripheral blood cellsDe novo synthesisAirway hyperreactivityAllergic asthmaHuman asthmaAsthma pathogenesisChildhood asthmaAsthma riskAsthmaORMDL3 expressionAsthma susceptibilityBlood cellsNovo synthesisSphingolipid synthesisFuture therapeuticsDe novo sphingolipid synthesisChildrenORMDL3 overexpressionRiskDihydroceramideCeramideGenotypesHyperreactivity
2018
Association networks in a matched case-control design – Co-occurrence patterns of preexisting chronic medical conditions in patients with major depression versus their matched controls
Kim MH, Banerjee S, Zhao Y, Wang F, Zhang Y, Zhu Y, DeFerio J, Evans L, Park S, Pathak J. Association networks in a matched case-control design – Co-occurrence patterns of preexisting chronic medical conditions in patients with major depression versus their matched controls. Journal Of Biomedical Informatics 2018, 87: 88-95. PMID: 30300713, PMCID: PMC6262847, DOI: 10.1016/j.jbi.2018.09.016.Peer-Reviewed Original ResearchConceptsChronic medical conditionsMajor depressive disorderNational sample cohortMedical conditionsCase-control designKorean National Health Insurance Service-National Sample CohortNational Health Insurance Service-National Sample CohortHealthcare service utilizationRegression modelingChronic conditionsMDD patientsDepressive disorderMajor depressionService utilizationDepression patientsMDD diagnosisPatientsComorbid featuresPlace of residenceSample cohortMDD casesSocioeconomic statusDemographic characteristics