ImmunoPET Imaging Identifies the Optimal Timepoint for Combination Therapy in Xenograft Models of Triple-Negative Breast Cancer
Li Z, Belitzky E, Blaha O, Cavaliere A, Katz S, Aboian M, Melegari L, Rajabimoghadam K, Kurpiewski S, Zhu X, Marquez-Nostra B. ImmunoPET Imaging Identifies the Optimal Timepoint for Combination Therapy in Xenograft Models of Triple-Negative Breast Cancer. Cancers 2023, 15: 1589. PMID: 36900378, PMCID: PMC10001369, DOI: 10.3390/cancers15051589.Peer-Reviewed Original ResearchTriple-negative breast cancerPositron emission tomographyDays post-treatment initiationCDX-011Longitudinal positron emission tomographyPost-treatment initiationTyrosine kinase inhibitorsWestern blot analysisTreatment initiationXenograft modelGPNMB expressionXenografted miceCombination therapyBreast cancerMDA-MB-468 xenograft modelBlot analysisKinase inhibitorsMDA-MB-231 xenograft modelCombination-treated groupControl-treated groupLower overall survivalVehicle control groupCombination of dasatinibSubgroup of miceTumor cell lysates