Effect on metabolic enzymes and thyroid receptors induced by BDE-47 by activation the pregnane X receptor in HepG2, a human hepatoma cell line
Hu X, Zhang J, Jiang Y, Lei Y, Lu L, Zhou J, Huang H, Fang D, Tao G. Effect on metabolic enzymes and thyroid receptors induced by BDE-47 by activation the pregnane X receptor in HepG2, a human hepatoma cell line. Toxicology In Vitro 2014, 28: 1377-1385. PMID: 25063376, DOI: 10.1016/j.tiv.2014.07.004.Peer-Reviewed Original ResearchConceptsPregnane X receptorThyroid receptorX receptorRegulation of CYP3A4Microsomal phase ITetra-bromodiphenyl etherHuman pregnane X receptorDual-luciferase reporterHepG2 cell modelBDE-47Human hepatoma cell lineDetailed underlying mechanismsMetabolic enzymesHepatoma cell lineThyroid hormonesBDE-47 treatmentToxicological evidencePhase IHealth effectsThyroid disruptionReceptorsExpression levelsHPXRUnderlying mechanismUGT1A3