Featured Publications
A Bayesian framework for incorporating exposure uncertainty into health analyses with application to air pollution and stillbirth
Comess S, Chang HH, Warren JL. A Bayesian framework for incorporating exposure uncertainty into health analyses with application to air pollution and stillbirth. Biostatistics 2022, 25: 20-39. PMID: 35984351, PMCID: PMC10724312, DOI: 10.1093/biostatistics/kxac034.Peer-Reviewed Original ResearchConceptsFull conditional distributionsEfficient model fittingStatistical modeling approachDensity estimation approachBayesian settingKernel density estimation approachPosterior outputBayesian frameworkConditional distributionModel fittingEstimation approachAccurate inferenceKDE approachModeling approachComparison metricsExposure uncertaintyUncertaintySecond stageApproachFittingInferencePredictionSimulationsModel comparison metricsFirst stageCritical window variable selection: estimating the impact of air pollution on very preterm birth
Warren JL, Kong W, Luben TJ, Chang HH. Critical window variable selection: estimating the impact of air pollution on very preterm birth. Biostatistics 2019, 21: 790-806. PMID: 30958877, PMCID: PMC7422642, DOI: 10.1093/biostatistics/kxz006.Peer-Reviewed Original ResearchMeSH KeywordsAir PollutantsAir PollutionBayes TheoremFemaleHumansInfant, NewbornMaternal ExposureParticulate MatterPregnancyPremature BirthConceptsHierarchical Bayesian frameworkBayesian frameworkStatistical modelVariable selectionImproved estimationCritical windowPreterm birthRisk parametersVery preterm birthAdverse birth outcomesControl analysisExposure-disease relationshipsDifferent reproductive outcomesBirth outcomesPregnant womenReproductive outcomesCase/control analysisAssessment of critical exposure and outcome windows in time-to-event analysis with application to air pollution and preterm birth study
Chang HH, Warren JL, Darrow LA, Reich BJ, Waller LA. Assessment of critical exposure and outcome windows in time-to-event analysis with application to air pollution and preterm birth study. Biostatistics 2015, 16: 509-521. PMID: 25572998, PMCID: PMC5963471, DOI: 10.1093/biostatistics/kxu060.Peer-Reviewed Original ResearchConceptsPreterm birthAir pollution exposureGestational air pollution exposureRisk of PTBPollution exposurePreterm Birth StudyCourse of pregnancyTime-varying exposureOngoing pregnancyBirth StudyGestational exposureReproductive epidemiologyWeek 30PregnancyWeekly exposureBirth recordsVulnerable periodPopulation studiesPositive associationCritical periodExposureInconsistent findingsAssociationExposure lengthFine particulate matterBayesian multinomial probit modeling of daily windows of susceptibility for maternal PM2.5 exposure and congenital heart defects
Warren JL, Stingone JA, Herring AH, Luben TJ, Fuentes M, Aylsworth AS, Langlois PH, Botto LD, Correa A, Olshan AF, Study B. Bayesian multinomial probit modeling of daily windows of susceptibility for maternal PM2.5 exposure and congenital heart defects. Statistics In Medicine 2016, 35: 2786-2801. PMID: 26853919, PMCID: PMC4899303, DOI: 10.1002/sim.6891.Peer-Reviewed Original ResearchMeSH KeywordsAir PollutantsBayes TheoremFemaleHeart Defects, CongenitalHumansInfant, NewbornMaternal ExposureModels, StatisticalParticulate MatterPregnancyConceptsGestational weeks 2Week 2PM2.5 exposureCongenital heartAmbient air pollution exposureMaternal PM2.5 exposureTetralogy of FallotNational Birth Defect Prevention StudyAir pollution exposureCritical periodDaily PM2.5 exposurePrevention StudyExposure modelEpidemiologic studiesFetal developmentHealth outcomesSignificant associationPollution exposureDay 53PregnancyDay 50Adverse effectsElevated exposureExposureHeart
2024
A scalar-on-quantile-function approach for estimating short-term health effects of environmental exposures
Zhang Y, Chang H, Warren J, Ebelt S. A scalar-on-quantile-function approach for estimating short-term health effects of environmental exposures. Biometrics 2024, 80: ujae008. PMID: 38477485, PMCID: PMC10934338, DOI: 10.1093/biomtc/ujae008.Peer-Reviewed Original ResearchMeSH KeywordsAir PollutantsAir PollutionCarbon MonoxideEnvironmental ExposureHumansParticulate MatterConceptsEmergency departmentAir pollutionHealth effects of environmental exposuresShort-term health effectsAnalysis of air pollutionStochastic Human ExposureAmbient air pollutionEnvironmental epidemiology studiesEffects of environmental exposuresAggregate health outcomesPopulation-level exposureHealth outcomesED visitsPopulation exposureHuman exposureExposure heterogeneitySpatial variationEpidemiological studiesEnvironmental exposuresPollutionHealth analysisEstimated effectsEffects of short-termVisitsQuantile function
2023
Effects of air pollution on adverse birth outcomes and pregnancy complications in the U.S. state of Kansas (2000–2015)
Hao H, Yoo S, Strickland M, Darrow L, D’Souza R, Warren J, Moss S, Wang H, Zhang H, Chang H. Effects of air pollution on adverse birth outcomes and pregnancy complications in the U.S. state of Kansas (2000–2015). Scientific Reports 2023, 13: 21476. PMID: 38052850, PMCID: PMC10697947, DOI: 10.1038/s41598-023-48329-5.Peer-Reviewed Original ResearchConceptsGestational diabetes mellitusAdverse birth outcomesLow birth weightGestational hypertensionBirth outcomesBirth weightPregnancy complicationsPreterm birthFirst trimesterRisk of GDMMaternal medical complicationsSingleton live birthsWeeks of pregnancyO3 exposureAdverse pregnancyPregnancy exposurePregnancy outcomesDiabetes mellitusMedical complicationsAdverse birthThird trimesterNeonatal mortalityResidential census tractsSocio-economic status factorsDiscrete-time survivalAssociations Between Long-Term Air Pollutant Exposure and 30-Day All-Cause Hospital Readmissions in US Patients With Stroke
Tran P, Warren J, Leifheit E, Goldstein L, Lichtman J. Associations Between Long-Term Air Pollutant Exposure and 30-Day All-Cause Hospital Readmissions in US Patients With Stroke. Stroke 2023, 54: e126-e129. PMID: 36729388, PMCID: PMC11059199, DOI: 10.1161/strokeaha.122.042265.Peer-Reviewed Original ResearchMeSH KeywordsAgedAir PollutantsAir PollutionEnvironmental ExposureHumansMedicareNitrogen DioxideParticulate MatterPatient ReadmissionStrokeUnited StatesConceptsLong-term air pollutant exposureAir pollutant exposureCause hospital readmissionHospital readmissionPollutant exposureMedicare beneficiaries agePerformance categoriesMatter 2.5Sulfur dioxide exposureCause readmission measureIschemic strokeStroke incidenceUS patientsHospital characteristicsSD increaseReadmissionCox modelReadmission measuresBeneficiaries ageLong-term exposureStrokePatientsMedicaid ServicesParticulate matter 2.5US fee
2017
Investigating the Impact of Maternal Residential Mobility on Identifying Critical Windows of Susceptibility to Ambient Air Pollution During Pregnancy
Warren JL, Son JY, Pereira G, Leaderer BP, Bell ML. Investigating the Impact of Maternal Residential Mobility on Identifying Critical Windows of Susceptibility to Ambient Air Pollution During Pregnancy. American Journal Of Epidemiology 2017, 187: 992-1000. PMID: 29053768, PMCID: PMC5928458, DOI: 10.1093/aje/kwx335.Peer-Reviewed Original ResearchConceptsLow birth weightTerm low birth weightMaternal residential mobilityBirth weightCritical windowBirth cohortWeekly exposurePregnancy week 16Adverse birth outcomesWindow of susceptibilityAmbient air pollutionPregnancy windowsBirth outcomesWeek 16Mother's residencePM10 exposurePregnancyResidential addressesExposure misclassificationDisease developmentCohortAir pollutionExposureAerodynamic diameterPossible mechanism