2004
Monitoring and modeling horizontal gene transfer
Nielsen KM, Townsend JP. Monitoring and modeling horizontal gene transfer. Nature Biotechnology 2004, 22: 1110-1114. PMID: 15340481, DOI: 10.1038/nbt1006.Peer-Reviewed Original ResearchConceptsHorizontal gene transfer eventsPopulation genetic approachesGene transfer eventsStrength of selectionHorizontal gene transferPopulation genetic modelsWild-type bacteriaLarge bacterial populationsHGT hypothesisBacterial generation timesHGT eventsTransgenic plantsGenetic approachesBacterial communitiesBacterial transformantsBacterial populationsPopulation sizeCurrent monitoring effortsGene transferTransfer eventsYears of growthGeneration timeGenetic modelsBacteriaTime of sampling
2003
Horizontal Acquisition of Divergent Chromosomal DNA in Bacteria: Effects of Mutator Phenotypes
Townsend JP, Nielsen KM, Fisher DS, Hartl DL. Horizontal Acquisition of Divergent Chromosomal DNA in Bacteria: Effects of Mutator Phenotypes. Genetics 2003, 164: 13-21. PMID: 12750317, PMCID: PMC1462543, DOI: 10.1093/genetics/164.1.13.Peer-Reviewed Original ResearchMeSH KeywordsData Interpretation, StatisticalEscherichia coliEvolution, MolecularGene Transfer, HorizontalGenetic VariationModels, GeneticConceptsGenetic variabilityDNA fragmentsBacterial populationsMore amino acid changesSpecific amino acid substitutionsAmino acid changesAmino acid substitutionsStudy of recombinationPresence of mutatorsRate of adaptationEnvironmental DNALong DNA fragmentsBacterial adaptationAdaptive potentialMutator phenotypeHorizontal acquisitionChromosomal DNAPopulation adaptationAcid substitutionsAcid changesMutatorDonor bacteriaE. coliPhenotypeDivergence