2020
Unmatched Level of Molecular Convergence among Deeply Divergent Complex Multicellular Fungi
Merényi Z, Prasanna AN, Wang Z, Kovács K, Hegedüs B, Bálint B, Papp B, Townsend JP, Nagy LG. Unmatched Level of Molecular Convergence among Deeply Divergent Complex Multicellular Fungi. Molecular Biology And Evolution 2020, 37: 2228-2240. PMID: 32191325, PMCID: PMC7403615, DOI: 10.1093/molbev/msaa077.Peer-Reviewed Original ResearchMeSH KeywordsAscomycotaBasidiomycotaBiological EvolutionFruiting Bodies, FungalGene Expression Regulation, DevelopmentalMultigene FamilyConceptsComplex multicellularityGene familyMulticellular fruiting bodiesGene family levelLarge phylogenetic distancesSimilar selection pressuresRecent common ancestorFungal ancestorsFungal genomesGenomic repertoireMolecular convergenceMulticellular fungiPhylogenetic distanceConvergent evolutionEvolutionary convergenceLarge cladeEvolutionary trajectoriesCommon ancestorIndependent evolutionNatural selectionSelection pressureEvolutionary predispositionMulticellularityCladeFruiting bodies
2013
Global Gene Expression and Focused Knockout Analysis Reveals Genes Associated with Fungal Fruiting Body Development in Neurospora crassa
Wang Z, Lopez-Giraldez F, Lehr N, Farré M, Common R, Trail F, Townsend JP. Global Gene Expression and Focused Knockout Analysis Reveals Genes Associated with Fungal Fruiting Body Development in Neurospora crassa. MSphere 2013, 13: 154-169. PMID: 24243796, PMCID: PMC3910948, DOI: 10.1128/ec.00248-13.Peer-Reviewed Original ResearchMeSH KeywordsDNA-Binding ProteinsFungal ProteinsGene DeletionGene Expression Regulation, DevelopmentalGene Expression Regulation, FungalGenes, Mating Type, FungalGenome, FungalNeurospora crassaSpores, FungalUp-RegulationConceptsPerithecial developmentNeurospora crassaGene expressionSexual developmentBody developmentFruiting-body developmentMost upregulated genesReverse genetics approachGlobal gene expressionSimilar expression patternsSame developmental stageMulticellular organismsSexual crossingMat AUnclassified proteinsDevelopmental traitsN. crassaKnockout analysisTranscriptomic landscapeType genesUpregulated genesGenetic basisDiverse functionsExpression patternsStage specificity
2012
RBE controls microRNA164 expression to effect floral organogenesis
Huang T, López-Giráldez F, Townsend JP, Irish VF. RBE controls microRNA164 expression to effect floral organogenesis. Development 2012, 139: 2161-2169. PMID: 22573623, DOI: 10.1242/dev.075069.Peer-Reviewed Original ResearchMeSH KeywordsArabidopsisArabidopsis ProteinsFlowersGene Expression Regulation, DevelopmentalGene Expression Regulation, PlantGenes, PlantMicroRNAsMutationOrgan SpecificityOrganogenesisPromoter Regions, GeneticProtein BindingRepressor ProteinsTime FactorsConceptsCUP-SHAPED COTYLEDON1Zinc finger transcriptional repressorKey transcriptional regulatorMiR164 expressionPetal organogenesisArabidopsis flowersPetal developmentPlant developmentEffector genesTranscriptional regulatorsTranscriptional repressorFloral organogenesisGene productsDevelopmental eventsConcomitant regulationGenesOrgan boundariesOrganogenesisExpressionMiR164cCUC2RepressorBoundary specificationPromoterFlowers
2006
Phase-specific gene expression underlying morphological adaptations of the dimorphic human pathogenic fungus, Coccidioides posadasii
Johannesson H, Kasuga T, Schaller RA, Good B, Gardner MJ, Townsend JP, Cole GT, Taylor JW. Phase-specific gene expression underlying morphological adaptations of the dimorphic human pathogenic fungus, Coccidioides posadasii. Fungal Genetics And Biology 2006, 43: 545-559. PMID: 16697669, DOI: 10.1016/j.fgb.2006.02.003.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, BiologicalCoccidioidesGene Expression ProfilingGene Expression Regulation, DevelopmentalGene Expression Regulation, FungalLogistic ModelsOligonucleotide Array Sequence AnalysisSpecies SpecificityConceptsGene expressionPhase-specific gene expressionPathogenic phaseNumber of genesConsistent differential expressionOpen reading frameDimorphic fungal pathogenDimorphic human pathogenic fungusHuman pathogenic fungiTranscriptional profilingEntire speciesEnvironmental stressReading frameComparative hybridizationMorphological adaptationsFungal pathogensCandidate genesSaprobic phasePathogenic fungiMetabolism of lipidsDifferential expressionGenesFungal isolatesElevated expressionDevelopmental phases