Featured Publications
Infection with alternate frequencies of SARS-CoV-2 vaccine boosting for patients undergoing antineoplastic cancer treatments
Townsend J, Hassler H, Emu B, Dornburg A. Infection with alternate frequencies of SARS-CoV-2 vaccine boosting for patients undergoing antineoplastic cancer treatments. Journal Of The National Cancer Institute 2023, 115: 1626-1628. PMID: 37599438, PMCID: PMC10699797, DOI: 10.1093/jnci/djad158.Peer-Reviewed Original ResearchConceptsReinfection riskAntineoplastic therapyAntibody dataSARS-CoV-2 infectionSARS-CoV-2 vaccinesChemotherapy-immunotherapy combinationsPfizer-BioNTech BNT162b2COVID-19 vaccinationHigh infection riskFrequent boostingRituximab therapyBreakthrough infectionsVaccination scheduleAntibody levelsBooster scheduleVaccination frequencyImmune responseAdditional interventionsReduced riskHigh riskHormonal treatmentGeneral populationNecessitating assessmentPatientsInfection risk
2016
One Health approach to cost-effective rabies control in India
Fitzpatrick MC, Shah HA, Pandey A, Bilinski AM, Kakkar M, Clark AD, Townsend JP, Abbas SS, Galvani AP. One Health approach to cost-effective rabies control in India. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: 14574-14581. PMID: 27994161, PMCID: PMC5187709, DOI: 10.1073/pnas.1604975113.Peer-Reviewed Original ResearchConceptsHuman rabiesRabies deathsCanine vaccinationStray dogsHuman rabies deathsRabies controlCost-effectiveness thresholdPostexposure vaccinationWHO criteriaDog bitesAutopsy dataHealth outcomesHealth approachSurveillance dataVaccinationCost-effective strategyDogsRabiesRabies surveillance dataOne-thirdVaccination strategies against respiratory syncytial virus
Yamin D, Jones FK, DeVincenzo JP, Gertler S, Kobiler O, Townsend JP, Galvani AP. Vaccination strategies against respiratory syncytial virus. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: 13239-13244. PMID: 27799521, PMCID: PMC5135296, DOI: 10.1073/pnas.1522597113.Peer-Reviewed Original ResearchConceptsRespiratory syncytial virusSyncytial virusVaccination strategiesAge-specific vaccination strategiesRSV vaccine candidatesSubstantial indirect protectionInfectious viral loadOngoing clinical trialsWeekly incidence ratesTargeting of childrenDifferent age groupsInfected childrenRSV vaccinationVaccination uptakeInfant hospitalizationViral loadVaccine mechanismVaccination programClinical trialsIncidence rateCommon causeRSV incidenceVaccine candidatesAge groupsRSV symptomsCost-effectiveness of next-generation vaccines: The case of pertussis
Fitzpatrick MC, Wenzel NS, Scarpino SV, Althouse BM, Atkins KE, Galvani AP, Townsend JP. Cost-effectiveness of next-generation vaccines: The case of pertussis. Vaccine 2016, 34: 3405-3411. PMID: 27087151, DOI: 10.1016/j.vaccine.2016.04.010.Peer-Reviewed Original ResearchConceptsNext-generation vaccinesDuration of protectionAdult boostersChildhood seriesAge-structured transmission modelVaccination coverage ratesCases of pertussisPublic health challengePerfect efficacyPertussis vaccinationPertussis vaccinePertussis incidenceCurrent vaccinesNew vaccinesPotential vaccinesGreater efficacyVaccineVaccine improvementHealth challengesAverage durationHealth benefitsEfficacyDoseShort durationPertussis
2015
Harnessing Case Isolation and Ring Vaccination to Control Ebola
Wells C, Yamin D, Ndeffo-Mbah ML, Wenzel N, Gaffney SG, Townsend JP, Meyers LA, Fallah M, Nyenswah TG, Altice FL, Atkins KE, Galvani AP. Harnessing Case Isolation and Ring Vaccination to Control Ebola. PLOS Neglected Tropical Diseases 2015, 9: e0003794. PMID: 26024528, PMCID: PMC4449200, DOI: 10.1371/journal.pntd.0003794.Peer-Reviewed Original ResearchConceptsRing vaccinationCase isolationContact tracingLimited initial supplyPost-exposure protectionMass vaccination campaignNon-pharmaceutical control measuresPublic health agenciesCandidate vaccinesVaccination campaignVaccinationCase contactsEbola casesEbola transmissionHealth agenciesIncidence dataLow efficacyVaccineEbola outbreakEffective alternativeMore contactEbolaSierra LeoneBeneficial supplementControl measures
2013
Probabilistic uncertainty analysis of epidemiological modeling to guide public health intervention policy
Gilbert JA, Meyers LA, Galvani AP, Townsend JP. Probabilistic uncertainty analysis of epidemiological modeling to guide public health intervention policy. Epidemics 2013, 6: 37-45. PMID: 24593920, PMCID: PMC4316830, DOI: 10.1016/j.epidem.2013.11.002.Peer-Reviewed Original ResearchConceptsProbabilistic uncertainty analysisParameter uncertaintiesTypical sensitivity analysisUncertainty analysisDynamic modelDynamic infectious disease modelsSensitivity analysisMathematical modelingEpidemiological modelingInfectious disease modelIntervention policiesPublic health intervention policiesGlobal uncertaintyPolicy makersModel predictionsEpidemiological outcomesQuantitative predictionsProbability of successPoint estimatesPolicyUncertaintyLevel of vaccinationRelative importanceModelingHealth policy
2012
Controlling Antimicrobial Resistance through Targeted, Vaccine-Induced Replacement of Strains
Tekle YI, Nielsen KM, Liu J, Pettigrew MM, Meyers LA, Galvani AP, Townsend JP. Controlling Antimicrobial Resistance through Targeted, Vaccine-Induced Replacement of Strains. PLOS ONE 2012, 7: e50688. PMID: 23227198, PMCID: PMC3515573, DOI: 10.1371/journal.pone.0050688.Peer-Reviewed Original ResearchConceptsFirst clinical interventionImportant public health toolPan-resistant strainsInsufficient immune responsePublic health toolMulti-resistant strainsStaphylococcus aureus genotypesVaccine efficacyNosocomial outbreaksDrug treatmentImmune responseResistant serotypesFrequent reasonHypothetical vaccineVaccine developmentStrain replacementVaccineInfectious diseasesAureus genotypesClinical interventionsInfectionHealth toolsAntimicrobial resistanceIntervention strategiesSerotypesPotential for Rabies Control through Dog Vaccination in Wildlife-Abundant Communities of Tanzania
Fitzpatrick MC, Hampson K, Cleaveland S, Meyers LA, Townsend JP, Galvani AP. Potential for Rabies Control through Dog Vaccination in Wildlife-Abundant Communities of Tanzania. PLOS Neglected Tropical Diseases 2012, 6: e1796. PMID: 22928056, PMCID: PMC3424251, DOI: 10.1371/journal.pntd.0001796.Peer-Reviewed Original ResearchThe influence of altruism on influenza vaccination decisions
Shim E, Chapman GB, Townsend JP, Galvani AP. The influence of altruism on influenza vaccination decisions. Journal Of The Royal Society Interface 2012, 9: 2234-2243. PMID: 22496100, PMCID: PMC3405754, DOI: 10.1098/rsif.2012.0115.Peer-Reviewed Original ResearchConceptsInfluenza vaccination decisionsVaccination decisionsImpact of altruismInfluence of altruismVaccination policyGame theoryPersonal payoffAltruismInfluenza vaccinationOptimal vaccination policiesDisease burdenPublic health outcomesHealth outcomesAltruistic motivationTotal costPolicyDecisionsEpidemiological modelPotential strategyPayoffsAssumptionSurvey studyMorbidityVaccinationFundamental assumptions