2018
Lvr, a Signaling System That Controls Global Gene Regulation and Virulence in Pathogenic Leptospira
Adhikarla H, Wunder EA, Mechaly AE, Mehta S, Wang Z, Santos L, Bisht V, Diggle P, Murray G, Adler B, Lopez F, Townsend JP, Groisman E, Picardeau M, Buschiazzo A, Ko AI. Lvr, a Signaling System That Controls Global Gene Regulation and Virulence in Pathogenic Leptospira. Frontiers In Cellular And Infection Microbiology 2018, 8: 45. PMID: 29600195, PMCID: PMC5863495, DOI: 10.3389/fcimb.2018.00045.Peer-Reviewed Original ResearchConceptsResponse regulatorTwo-component system proteinsDNA-binding response regulatorGlobal transcriptional regulationHybrid histidine kinaseGlobal gene regulationNovel signal pathwayComprehensive genomic analysisPhosphotransfer assaysTCS genesHistidine kinaseGene duplicationTranscriptional regulationGene regulationCorresponding genesPhylogenetic analysisGenomic analysisMolecular basisMutant strainSystem proteinsSignaling systemInfection processGenesBranched pathwayVirulence
2014
Gene Expression Differences among Three Neurospora Species Reveal Genes Required for Sexual Reproduction in Neurospora crassa
Lehr NA, Wang Z, Li N, Hewitt DA, López-Giráldez F, Trail F, Townsend JP. Gene Expression Differences among Three Neurospora Species Reveal Genes Required for Sexual Reproduction in Neurospora crassa. PLOS ONE 2014, 9: e110398. PMID: 25329823, PMCID: PMC4203796, DOI: 10.1371/journal.pone.0110398.Peer-Reviewed Original ResearchConceptsNeurospora crassaSexual reproductionN. crassaGenetic basisThree-dimensional fruiting bodiesSexual spore productionN. crassa geneBody developmentDiverse life historiesGenome-wide transcriptomicsSexual developmentStudy of meiosisGene expression differencesList of genesGene expression levelsMeiotic machineryMeiosis genesOrthologous genesSporulation genesNeurospora speciesGlomerella graminicolaEvolutionary timeAnimal taxaPerithecium formationLife history
2012
Sex-specific gene expression during asexual development of Neurospora crassa
Wang Z, Kin K, López-Giráldez F, Johannesson H, Townsend JP. Sex-specific gene expression during asexual development of Neurospora crassa. Fungal Genetics And Biology 2012, 49: 533-543. PMID: 22626843, PMCID: PMC3397379, DOI: 10.1016/j.fgb.2012.05.004.Peer-Reviewed Original ResearchConceptsMating-type genesAsexual developmentMating typesNeurospora crassaGene expressionSex-specific gene expressionFungal life historyLight-responsive genesOverall gene expressionExpression levelsDifferent mating typesExpression of pheromonePheromone genesHigh expression levelsMat AType genesLife historyResponse genesExpression differencesDevelopment stagesGenesClonal developmentImpact of lightReceptor geneCrassa
2008
Sleuthing the difference a nucleotide can make
Townsend JP. Sleuthing the difference a nucleotide can make. Molecular Ecology 2008, 17: 2793-2795. PMID: 18565029, DOI: 10.1111/j.1365-294x.2008.03824.x.Peer-Reviewed Original ResearchConceptsGene expression polymorphismsExpression polymorphismsGenetic variationGene expressionGenome-wide gene expressionPotential evolutionary impactCis-regulatory regionsAmino acid sensorsDifferential gene expressionSingle nucleotide insertionEcological genomicsEvolutionary impactNatural populationsDifferential fitnessYeast SaccharomycesTranscription factorsGenetic basisNatural isolatesHomonucleotide repeatsNatural variationNucleotide insertionEnvironment interactionPolymorphismAcid sensorsSSY1
2005
Long-oligomer microarray profiling in Neurospora crassa reveals the transcriptional program underlying biochemical and physiological events of conidial germination
Kasuga T, Townsend JP, Tian C, Gilbert LB, Mannhaupt G, Taylor JW, Glass NL. Long-oligomer microarray profiling in Neurospora crassa reveals the transcriptional program underlying biochemical and physiological events of conidial germination. Nucleic Acids Research 2005, 33: 6469-6485. PMID: 16287898, PMCID: PMC1283539, DOI: 10.1093/nar/gki953.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBayes TheoremBlotting, NorthernCluster AnalysisDatabases, Nucleic AcidDictyosteliumExpressed Sequence TagsGene Expression ProfilingGenes, FungalNeurospora crassaOligonucleotide Array Sequence AnalysisOligonucleotide ProbesPromoter Regions, GeneticReproducibility of ResultsRNA, MessengerSpores, FungalTranscription, GeneticUstilagoConceptsConidial germinationGene expression levelsNeurospora crassaGene expressionPhytopathogenic fungus Ustilago maydisSocial amoeba Dictyostelium discoideumFilamentous ascomycete speciesPutative regulatory componentFungus Ustilago maydisAmoeba Dictyostelium discoideumExpression levelsAscomycete speciesRibosomal biogenesisRelative gene expression levelsNovel genesTranscriptional programsUstilago maydisTranscriptional profilingDictyostelium discoideumFunctional predictionTranscriptional mechanismsRegulatory componentsFilamentous fungiExpression profilesMicroarray profiling
2002
Pathway Processor: A Tool for Integrating Whole-Genome Expression Results into Metabolic Networks
Grosu P, Townsend JP, Hartl DL, Cavalieri D. Pathway Processor: A Tool for Integrating Whole-Genome Expression Results into Metabolic Networks. Genome Research 2002, 12: 1121-1126. PMID: 12097350, PMCID: PMC186628, DOI: 10.1101/gr.226602.Peer-Reviewed Original Research