2019
APOBEC-induced mutations and their cancer effect size in head and neck squamous cell carcinoma
Cannataro VL, Gaffney SG, Sasaki T, Issaeva N, Grewal NKS, Grandis JR, Yarbrough WG, Burtness B, Anderson KS, Townsend JP. APOBEC-induced mutations and their cancer effect size in head and neck squamous cell carcinoma. Oncogene 2019, 38: 3475-3487. PMID: 30647454, PMCID: PMC6499643, DOI: 10.1038/s41388-018-0657-6.Peer-Reviewed Original ResearchConceptsPositive selectionCancer phenotypeStrong positive selectionIntensity of selectionEffects of mutationsBasis of mutationsSomatic genetic variantsSomatic evolutionNeutral driftMutational processesAPOBEC mutagenesisBiochemical experimentsSelection intensityMolecular understandingCytosine basesIndividual substitutionsAPOBEC3B proteinMutant stateMutational signaturesGenetic variantsNeck squamous cell carcinomaMutationsE545KGene variantsPhenotype
2014
Detecting rare gene transfer events in bacterial populations
Nielsen KM, Bøhn T, Townsend JP. Detecting rare gene transfer events in bacterial populations. Frontiers In Microbiology 2014, 4: 415. PMID: 24432015, PMCID: PMC3882822, DOI: 10.3389/fmicb.2013.00415.Peer-Reviewed Original ResearchHorizontal gene transferHGT eventsHost fitnessBacterial populationsDetection of HGTNew hostPopulation sizeGene transfer eventsKey population genetics parametersStrong positive selectionPopulation genetic parametersGene transfer mechanismsPopulation genetic modelingLarge population sizesGenetic diversityRelative population sizeGenetic compatibilityHGT ratesPositive selectionGenetic variationMutational processesNovel functionDonor organismHighlight knowledge gapsStructured populations