Featured Publications
Cancer Relevance of Human Genes
Qing T, Mohsen H, Cannataro VL, Marczyk M, Rozenblit M, Foldi J, Murray M, Townsend J, Kluger Y, Gerstein M, Pusztai L. Cancer Relevance of Human Genes. Journal Of The National Cancer Institute 2022, 114: 988-995. PMID: 35417011, PMCID: PMC9275765, DOI: 10.1093/jnci/djac068.Peer-Reviewed Original ResearchConceptsCore cancer genesHuman genesFunctional importanceSomatic mutation frequencySelection pressureGene/protein networksCancer genesHigher somatic mutation frequencyNegative selection pressureGene-gene interaction networksMutation frequencyProtein-truncating variantsGenomic contextCell viabilityGenes decreasesCancer Genome AtlasInteraction networksProtein networkCancer relevanceCancer cell viabilityCell survivalGenesCancer biologyGenome AtlasSearch tools
2020
Unmatched Level of Molecular Convergence among Deeply Divergent Complex Multicellular Fungi
Merényi Z, Prasanna AN, Wang Z, Kovács K, Hegedüs B, Bálint B, Papp B, Townsend JP, Nagy LG. Unmatched Level of Molecular Convergence among Deeply Divergent Complex Multicellular Fungi. Molecular Biology And Evolution 2020, 37: 2228-2240. PMID: 32191325, PMCID: PMC7403615, DOI: 10.1093/molbev/msaa077.Peer-Reviewed Original ResearchConceptsComplex multicellularityGene familyMulticellular fruiting bodiesGene family levelLarge phylogenetic distancesSimilar selection pressuresRecent common ancestorFungal ancestorsFungal genomesGenomic repertoireMolecular convergenceMulticellular fungiPhylogenetic distanceConvergent evolutionEvolutionary convergenceLarge cladeEvolutionary trajectoriesCommon ancestorIndependent evolutionNatural selectionSelection pressureEvolutionary predispositionMulticellularityCladeFruiting bodies