2014
Detecting rare gene transfer events in bacterial populations
Nielsen KM, Bøhn T, Townsend JP. Detecting rare gene transfer events in bacterial populations. Frontiers In Microbiology 2014, 4: 415. PMID: 24432015, PMCID: PMC3882822, DOI: 10.3389/fmicb.2013.00415.Peer-Reviewed Original ResearchHorizontal gene transferHGT eventsHost fitnessBacterial populationsDetection of HGTNew hostPopulation sizeGene transfer eventsKey population genetics parametersStrong positive selectionPopulation genetic parametersGene transfer mechanismsPopulation genetic modelingLarge population sizesGenetic diversityRelative population sizeGenetic compatibilityHGT ratesPositive selectionGenetic variationMutational processesNovel functionDonor organismHighlight knowledge gapsStructured populations
2012
Assessing the Probability of Detection of Horizontal Gene Transfer Events in Bacterial Populations
Townsend JP, Bøhn T, Nielsen KM. Assessing the Probability of Detection of Horizontal Gene Transfer Events in Bacterial Populations. Frontiers In Microbiology 2012, 3: 27. PMID: 22363321, PMCID: PMC3282476, DOI: 10.3389/fmicb.2012.00027.Peer-Reviewed Original ResearchHorizontal gene transfer eventsGene transfer eventsHGT eventsBacterial populationsPopulation genetics theoryTransfer eventsPopulation genetic modelingLevels of selectionBacterial generation timesGenetic driftNatural selectionInitial transformantsGenetic theoryExogenous DNAAntibiotic resistance genesGenetic materialResistance genesStructured populationsImmediate offspringBacterial genotypesGeneration timeHGTBacteriaDNAGrowth dynamics
2004
Monitoring and modeling horizontal gene transfer
Nielsen KM, Townsend JP. Monitoring and modeling horizontal gene transfer. Nature Biotechnology 2004, 22: 1110-1114. PMID: 15340481, DOI: 10.1038/nbt1006.Peer-Reviewed Original ResearchConceptsHorizontal gene transfer eventsPopulation genetic approachesGene transfer eventsStrength of selectionHorizontal gene transferPopulation genetic modelsWild-type bacteriaLarge bacterial populationsHGT hypothesisBacterial generation timesHGT eventsTransgenic plantsGenetic approachesBacterial communitiesBacterial transformantsBacterial populationsPopulation sizeCurrent monitoring effortsGene transferTransfer eventsYears of growthGeneration timeGenetic modelsBacteriaTime of sampling
2003
Horizontal Acquisition of Divergent Chromosomal DNA in Bacteria: Effects of Mutator Phenotypes
Townsend JP, Nielsen KM, Fisher DS, Hartl DL. Horizontal Acquisition of Divergent Chromosomal DNA in Bacteria: Effects of Mutator Phenotypes. Genetics 2003, 164: 13-21. PMID: 12750317, PMCID: PMC1462543, DOI: 10.1093/genetics/164.1.13.Peer-Reviewed Original ResearchConceptsGenetic variabilityDNA fragmentsBacterial populationsMore amino acid changesSpecific amino acid substitutionsAmino acid changesAmino acid substitutionsStudy of recombinationPresence of mutatorsRate of adaptationEnvironmental DNALong DNA fragmentsBacterial adaptationAdaptive potentialMutator phenotypeHorizontal acquisitionChromosomal DNAPopulation adaptationAcid substitutionsAcid changesMutatorDonor bacteriaE. coliPhenotypeDivergence