2023
Genetic Susceptibility to Nonalcoholic Fatty Liver Disease and Risk for Pancreatic Cancer: Mendelian Randomization.
King S, Veliginti S, Brouwers M, Ren Z, Zheng W, Setiawan V, Wilkens L, Shu X, Arslan A, Beane Freeman L, Bracci P, Canzian F, Du M, Gallinger S, Giles G, Goodman P, Haiman C, Kogevinas M, Kooperberg C, LeMarchand L, Neale R, Visvanathan K, White E, Albanes D, Andreotti G, Babic A, Berndt S, Brais L, Brennan P, Buring J, Rabe K, Bamlet W, Chanock S, Fuchs C, Gaziano J, Giovannucci E, Hackert T, Hassan M, Katzke V, Kurtz R, Lee I, Malats N, Murphy N, Oberg A, Orlow I, Porta M, Real F, Rothman N, Sesso H, Silverman D, Thompson I, Wactawski-Wende J, Wang X, Wentzensen N, Yu H, Zeleniuch-Jacquotte A, Yu K, Wolpin B, Duell E, Li D, Hung R, Perdomo S, McCullough M, Freedman N, Patel A, Peters U, Riboli E, Sund M, Tjønneland A, Zhong J, Van Den Eeden S, Kraft P, Risch H, Amundadottir L, Klein A, Stolzenberg-Solomon R, Antwi S. Genetic Susceptibility to Nonalcoholic Fatty Liver Disease and Risk for Pancreatic Cancer: Mendelian Randomization. Cancer Epidemiology Biomarkers & Prevention 2023, 32: 1265-1269. PMID: 37351909, PMCID: PMC10529823, DOI: 10.1158/1055-9965.epi-23-0453.Peer-Reviewed Original ResearchConceptsNonalcoholic fatty liver diseasePancreatic cancer riskFatty liver diseasePancreatic cancerCancer riskLiver diseaseGenetic predispositionMendelian randomizationPancreatic Cancer Case-Control ConsortiumConfidence intervalsPancreatic Cancer Cohort ConsortiumPC risk factorsMR methodsRisk factorsGenome-wide association studiesGenetic susceptibilityLogistic regressionCancerMetabolic perturbationsMetabolic conditionsRiskDiseaseGenetic variantsAssociationPredisposition
2022
Dietary omega-3 fatty acids and endometrial cancer risk in the Epidemiology of Endometrial Cancer Consortium: An individual-participant meta-analysis
Brasky T, Hade E, Cohn D, Newton A, Petruzella S, O'Connell K, Bertrand K, Cook L, De Vivo I, Du M, Freudenheim J, Friedenreich C, Goodman M, Gorzelitz J, Ibiebele T, Krogh V, Liao L, Lipworth L, Lu L, McCann S, O'Mara T, Palmer J, Ponte J, Prizment A, Risch H, Sandin S, Schouten L, Setiawan V, Shu X, Trabert B, van den Brandt P, Webb P, Wentzensen N, Wilkens L, Wolk A, Yu H, Neuhouser M. Dietary omega-3 fatty acids and endometrial cancer risk in the Epidemiology of Endometrial Cancer Consortium: An individual-participant meta-analysis. Gynecologic Oncology 2022, 169: 137-146. PMID: 36934308, PMCID: PMC10025515, DOI: 10.1016/j.ygyno.2022.10.015.Peer-Reviewed Original ResearchConceptsEndometrial cancer riskEndometrial Cancer ConsortiumHigh dietary intakeCancer riskDietary intakeObese womenOdds ratioCancer ConsortiumDietary omega-3 fatty acidsOmega-3 fatty acidsEnergy-adjusted quartilesEndometrial cancer casesEndometrial cancer incidenceProspective cohort studyFood frequency questionnaireNormal-weight womenFatty acid intakeAdjusted odds ratioBody mass indexLong-chain omega-3Anti-inflammatory propertiesSubgroup of womenConfidence intervalsCase-control studyTwo-stage individual participant data
2018
Food withdrawal alters the gut microbiota and metabolome in mice
Zheng X, Zhou K, Zhang Y, Han X, Zhao A, Liu J, Qu C, Ge K, Huang F, Hernandez B, Yu H, Panee J, Chen T, Jia W, Jia W. Food withdrawal alters the gut microbiota and metabolome in mice. The FASEB Journal 2018, 32: 4878-4888. PMID: 29620942, PMCID: PMC9292403, DOI: 10.1096/fj.201700614r.Peer-Reviewed Original ResearchConceptsHigh-fat dietFood withdrawalGut microbiotaObese miceWithdrawal altersAbundance of microbesHost metabolic changesFree fatty acid metabolismBeneficial effectsNormal chow groupAbundance of metabolitesNormal lean miceFatty acid metabolismPathogenic ProteobacteriaMolecular mechanismsBranched-chain amino acidsHost serum metabolomeChain amino acidsCecal microbiomeAmino acidsHFD groupHFD miceDietary interventionLean miceNormal mice
2008
Insulin, Insulin-Like Growth Factor-I, and Risk of Breast Cancer in Postmenopausal Women
Gunter MJ, Hoover DR, Yu H, Wassertheil-Smoller S, Rohan TE, Manson JE, Li J, Ho GY, Xue X, Anderson GL, Kaplan RC, Harris TG, Howard BV, Wylie-Rosett J, Burk RD, Strickler HD. Insulin, Insulin-Like Growth Factor-I, and Risk of Breast Cancer in Postmenopausal Women. Journal Of The National Cancer Institute 2008, 101: 48-60. PMID: 19116382, PMCID: PMC2639294, DOI: 10.1093/jnci/djn415.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedBiomarkers, TumorBlood GlucoseBody Mass IndexBreast NeoplasmsCase-Control StudiesEstradiolEstrogen Replacement TherapyFemaleHumansHyperinsulinismInsulinInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor IMiddle AgedMultivariate AnalysisObesityOdds RatioPostmenopauseProportional Hazards ModelsProspective StudiesRisk AssessmentRisk FactorsStatistics, NonparametricConceptsInsulin-like growth factorLevels of insulinBreast cancerInsulin levelsRisk factorsPostmenopausal womenGrowth factorMultiple breast cancer risk factorsMultivariable Cox proportional hazards modelsWomen's Health Initiative Observational StudyBreast cancer case subjectsBreast cancer risk factorsCox proportional hazards modelHormone therapy useIncident breast cancerIndependent risk factorPostmenopausal breast cancerCancer risk factorsCase-cohort studyProportional hazards modelTotal IGFNondiabetic womenBaseline characteristicsFree IGFProspective cohortA Prospective Evaluation of Insulin and Insulin-like Growth Factor-I as Risk Factors for Endometrial Cancer
Gunter M, Hoover D, Yu H, Wassertheil-Smoller S, Manson J, Li J, Harris T, Rohan T, Xue X, Ho G, Einstein M, Kaplan R, Burk R, Wylie-Rosett J, Pollak M, Anderson G, Howard B, Strickler H. A Prospective Evaluation of Insulin and Insulin-like Growth Factor-I as Risk Factors for Endometrial Cancer. Cancer Epidemiology Biomarkers & Prevention 2008, 17: 921-929. PMID: 18398032, PMCID: PMC3090086, DOI: 10.1158/1055-9965.epi-07-2686.Peer-Reviewed Original ResearchMeSH KeywordsAgedBody Mass IndexCarcinoma, EndometrioidEndometrial NeoplasmsEstradiolFemaleHumansHypoglycemic AgentsInsulinInsulin-Like Growth Factor Binding Protein 1Insulin-Like Growth Factor Binding Protein 3Middle AgedMulticenter Studies as TopicObesityProportional Hazards ModelsProspective StudiesRisk FactorsConceptsInsulin-like growth factorEndometrial cancerEndometrioid adenocarcinomaRisk factorsFree IGFObese womenEstrogen levelsWomen's Health Initiative Observational StudyFree IGF-I levelsIGF-binding protein-3Growth factorBaseline serum specimensIncident endometrial cancerHormone therapy useIGF-I levelsMain histologic typesCase-cohort studyMajor risk factorHigh estrogen levelsTotal IGFPostmenopausal womenHormone therapyProspective cohortRandom subcohortTherapy use
2005
Tipping the Scales: The Effect of Literacy on Obese Patients’ Knowledge and Readiness to Lose Weight
Kennen E, Davis T, Huang J, Yu H, Carden D, Bass R, Arnold C. Tipping the Scales: The Effect of Literacy on Obese Patients’ Knowledge and Readiness to Lose Weight. Southern Medical Journal 2005, 98: 15-18. PMID: 15678634, DOI: 10.1097/01.smj.0000146617.21240.49.Peer-Reviewed Original ResearchConceptsObese patientsOverweight/obese patientsWeight lossHalf of patientsThird of patientsPrimary care clinicsAdverse health consequencesMean respondent ageLiteracy levelsCare clinicsPatient interviewsAdult outpatientsPatient educationPatientsHealth consequencesPublic hospitalsConvenience sampleLow literacyLow literacy skillsSignificant relationRespondent ageOverweightObesityOutpatientsLevels
2004
Physicians’ Weight Loss Counseling in Two Public Hospital Primary Care Clinics
Huang J, Yu H, Marin E, Brock S, Carden D, Davis T. Physicians’ Weight Loss Counseling in Two Public Hospital Primary Care Clinics. Academic Medicine 2004, 79: 156-161. PMID: 14744717, DOI: 10.1097/00001888-200402000-00012.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAttitude of Health PersonnelClinical CompetenceCounselingDiabetes Mellitus, Type 2FemaleFocus GroupsHospitals, PublicHumansHyperlipidemiasInterviews as TopicLogistic ModelsLouisianaMaleMiddle AgedObesityOutpatient Clinics, HospitalPhysician's RolePractice Patterns, Physicians'Primary Health CareSampling StudiesWeight LossConceptsWeight loss counselingWeight loss recommendationsPrimary care clinicsPatient understandingWeight lossCare clinicsPatient recallLouisiana State University Health Sciences Center-ShreveportHospital primary care clinicPrimary care physiciansWeight loss strategiesRisk of obesityWeight management strategiesDistinct clinical diagnosisStage of readinessStructured exit interviewsObese patientsPhysician counselingCare physiciansPhysician barriersWeight managementLoss strategiesClinical diagnosisPatientsPhysicians
2003
Prevalence of Overweight, Obesity, and Associated Diseases among Outpatients in a Public Hospital
Huang J, Marin E, Yu H, Carden D, Arnold C, Davis T, Banks D. Prevalence of Overweight, Obesity, and Associated Diseases among Outpatients in a Public Hospital. Southern Medical Journal 2003, 96: 558-562. PMID: 12938782, DOI: 10.1097/01.smj.0000054725.35262.d4.Peer-Reviewed Original ResearchConceptsBody mass indexPrevalence of obesityPublic hospitalsLouisiana State University Health Sciences Center-ShreveportHigher body mass indexObesity-associated conditionsPercent of patientsTertiary health centerPrimary care patientsPublic hospital patientsPrevalence of overweightChronic medical conditionsObesity-related diseasesCross-sectional surveyStructure of careObese patientsCare patientsMass indexHospital patientsHealth centersMedical conditionsIndigent populationAssociated diseaseObesity ratesPatients
1997
Prostate-Specific Antigen in Female Serum, a Potential New Marker of Androgen Excess
Melegos D, Yu H, Ashok M, Wang C, Stanczyk F, Diamandis E. Prostate-Specific Antigen in Female Serum, a Potential New Marker of Androgen Excess. The Journal Of Clinical Endocrinology & Metabolism 1997, 82: 777-780. PMID: 9062481, DOI: 10.1210/jcem.82.3.3792.Peer-Reviewed Original ResearchConceptsProstate-specific antigenMarker of androgen excessSerum prostate-specific antigenHirsute womenReceiver operating characteristicAndrogen actionAndrogen excessLevels of prostate-specific antigenProstate-specific antigen levelProstate-specific antigen geneFemale serumAction of steroid hormone receptorsMarker of androgen actionAlpha-androstanediol glucuronideSerum PSA levelsFerriman-Gallwey scorePotential new markerSteroid hormone receptorsPSA levelsProstate-specificHyperandrogenic statePatient ageAlpha-androstanediolAlpha-AgBiochemical markers