2001
The relation of type 2 diabetes and cancer.
Strickler H, Wylie-Rosett J, Rohan T, Hoover D, Smoller S, Burk R, Yu H. The relation of type 2 diabetes and cancer. Diabetes Technology & Therapeutics 2001, 3: 263-74. PMID: 11478333, DOI: 10.1089/152091501300209633.Peer-Reviewed Original ResearchConceptsType 2 diabetesHigh waist circumferenceBody mass indexAdditional risk factorsInsulin-like growthCommon human malignanciesWaist circumferenceHip ratioMass indexOccult tumorsVisceral fatProspective InvestigationRisk factorsEtiologic associationSedentary lifestyleConsistent positive resultsElevated riskAge 50Cancer associationCurrent evidenceDiabetesEnergy intakeMethodologic issuesHuman malignanciesCancer
2000
Role of the Insulin-Like Growth Factor Family in Cancer Development and Progression
Yu H, Rohan T. Role of the Insulin-Like Growth Factor Family in Cancer Development and Progression. Journal Of The National Cancer Institute 2000, 92: 1472-1489. PMID: 10995803, DOI: 10.1093/jnci/92.18.1472.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAlcohol DrinkingAnimalsApoptosisCase-Control StudiesCell DivisionDisease ProgressionEnergy IntakeEpidemiologic StudiesExerciseFeeding BehaviorHumansInsulin-Like Growth Factor Binding ProteinsLife StyleNeoplasmsPredictive Value of TestsPrognosisReceptors, SomatomedinSex FactorsSmokingSomatomedinsConceptsInsulin-like growth factorIGF-binding proteinsRole of IGFsEffects of IGFActions of IGFsCancer growthInsulin-like growth factor (IGF) familyGrowth factorIGF-I levelsCell proliferationIGF-I receptorHigher energy intakeGrowth factor familyIGFBP proteasesIGFBP-3Etiology of cancerMitogenic growth factorsCommon cancerCancer preventionEpidemiologic studiesHigh-energy dietCancer riskEnergy restrictionEnergy intakeCancer development
1999
Insulin-like growth factors and cancer.
Yu H, Berkel H. Insulin-like growth factors and cancer. Journal Of The Louisiana State Medical Society 1999, 151: 218-23. PMID: 10234899.Peer-Reviewed Original ResearchConceptsInsulin-like growth factorIGF binding proteinIGF-1Growth hormoneIGF familyInvolvement of IGFsEffects of IGFActions of IGFsGrowth factorGH replacement therapyCancer cellsIGF-1 receptorLong-term safetyAnti-proliferative effectsAging-related diseasesProgression of cancerTreatment warrantsReplacement therapyVitamin DCancer preventionIGF-1RIGF-2Epidemiologic studiesWild-type p53 proteinCancer etiology