2008
Insulin, Insulin-Like Growth Factor-I, and Risk of Breast Cancer in Postmenopausal Women
Gunter MJ, Hoover DR, Yu H, Wassertheil-Smoller S, Rohan TE, Manson JE, Li J, Ho GY, Xue X, Anderson GL, Kaplan RC, Harris TG, Howard BV, Wylie-Rosett J, Burk RD, Strickler HD. Insulin, Insulin-Like Growth Factor-I, and Risk of Breast Cancer in Postmenopausal Women. Journal Of The National Cancer Institute 2008, 101: 48-60. PMID: 19116382, PMCID: PMC2639294, DOI: 10.1093/jnci/djn415.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedBiomarkers, TumorBlood GlucoseBody Mass IndexBreast NeoplasmsCase-Control StudiesEstradiolEstrogen Replacement TherapyFemaleHumansHyperinsulinismInsulinInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor IMiddle AgedMultivariate AnalysisObesityOdds RatioPostmenopauseProportional Hazards ModelsProspective StudiesRisk AssessmentRisk FactorsStatistics, NonparametricConceptsInsulin-like growth factorLevels of insulinBreast cancerInsulin levelsRisk factorsPostmenopausal womenGrowth factorMultiple breast cancer risk factorsMultivariable Cox proportional hazards modelsWomen's Health Initiative Observational StudyBreast cancer case subjectsBreast cancer risk factorsCox proportional hazards modelHormone therapy useIncident breast cancerIndependent risk factorPostmenopausal breast cancerCancer risk factorsCase-cohort studyProportional hazards modelTotal IGFNondiabetic womenBaseline characteristicsFree IGFProspective cohortA Prospective Evaluation of Insulin and Insulin-like Growth Factor-I as Risk Factors for Endometrial Cancer
Gunter M, Hoover D, Yu H, Wassertheil-Smoller S, Manson J, Li J, Harris T, Rohan T, Xue X, Ho G, Einstein M, Kaplan R, Burk R, Wylie-Rosett J, Pollak M, Anderson G, Howard B, Strickler H. A Prospective Evaluation of Insulin and Insulin-like Growth Factor-I as Risk Factors for Endometrial Cancer. Cancer Epidemiology Biomarkers & Prevention 2008, 17: 921-929. PMID: 18398032, PMCID: PMC3090086, DOI: 10.1158/1055-9965.epi-07-2686.Peer-Reviewed Original ResearchMeSH KeywordsAgedBody Mass IndexCarcinoma, EndometrioidEndometrial NeoplasmsEstradiolFemaleHumansHypoglycemic AgentsInsulinInsulin-Like Growth Factor Binding Protein 1Insulin-Like Growth Factor Binding Protein 3Middle AgedMulticenter Studies as TopicObesityProportional Hazards ModelsProspective StudiesRisk FactorsConceptsInsulin-like growth factorEndometrial cancerEndometrioid adenocarcinomaRisk factorsFree IGFObese womenEstrogen levelsWomen's Health Initiative Observational StudyFree IGF-I levelsIGF-binding protein-3Growth factorBaseline serum specimensIncident endometrial cancerHormone therapy useIGF-I levelsMain histologic typesCase-cohort studyMajor risk factorHigh estrogen levelsTotal IGFPostmenopausal womenHormone therapyProspective cohortRandom subcohortTherapy useInsulin-Like Growth Factor Axis and Oncogenic Human Papillomavirus Natural History
Harris T, Burk R, Yu H, Minkoff H, Massad L, Watts D, Zhong Y, Gange S, Kaplan R, Anastos K, Levine A, Moxley M, Xue X, Fazzari M, Palefsky J, Strickler H. Insulin-Like Growth Factor Axis and Oncogenic Human Papillomavirus Natural History. Cancer Epidemiology Biomarkers & Prevention 2008, 17: 245-248. PMID: 18199731, DOI: 10.1158/1055-9965.epi-07-0686.Peer-Reviewed Original ResearchConceptsOncogenic human papillomavirusHuman papillomavirusNatural historyCervical neoplasiaInsulin-like growth factor (IGF) axisHuman papillomavirus (HPV) natural historyInsulin-like growth factorBaseline serum specimensDNA PCR testingOncogenic HPV infectionIGF-I levelsHigher serum levelsGrowth factor axisTotal IGFHPV infectionIGFBP-3Serum levelsCervical cancerHigher IGFIGF axisViral causeCervical cytologyCommon cancerProspective dataAbundant IGFBPInsulin, Insulin-like Growth Factor-I, Endogenous Estradiol, and Risk of Colorectal Cancer in Postmenopausal Women
Gunter MJ, Hoover DR, Yu H, Wassertheil-Smoller S, Rohan TE, Manson JE, Howard BV, Wylie-Rosett J, Anderson GL, Ho GY, Kaplan RC, Li J, Xue X, Harris TG, Burk RD, Strickler HD. Insulin, Insulin-like Growth Factor-I, Endogenous Estradiol, and Risk of Colorectal Cancer in Postmenopausal Women. Cancer Research 2008, 68: 329-337. PMID: 18172327, PMCID: PMC4225702, DOI: 10.1158/0008-5472.can-07-2946.Peer-Reviewed Original ResearchConceptsInsulin-like growth factorFree IGFColorectal cancerPostmenopausal womenEndogenous estradiolWaist circumferenceWomen's Health Initiative Observational StudyIncident colorectal cancer casesGrowth factorBaseline serum specimensColorectal cancer incidenceColorectal cancer casesEndogenous estradiol levelsColorectal Cancer StudyStrong mitogenic effectIndependent biological pathwaysTotal IGFObese patientsProspective cohortRandom subcohortNondiabetic subjectsEstradiol levelsRisk factorsCancer incidenceExtreme quartiles
2007
IGF-I in epithelial ovarian cancer and its role in disease progression
Brokaw J, Katsaros D, Wiley A, Lu L, Su D, Sochirca O, de la Longrais IA, Mayne S, Risch H, Yu H. IGF-I in epithelial ovarian cancer and its role in disease progression. Growth Factors 2007, 25: 346-354. PMID: 18236213, DOI: 10.1080/08977190701838402.Peer-Reviewed Original ResearchConceptsIGF-I transcriptsDisease progressionOvarian cancerTumor progressionEpithelial ovarian cancer patientsIGF-I mRNA expressionInsulin-like growth factorParacrine/autocrine regulationIGF-I activityEpithelial ovarian cancerIGF-I actionOvarian cancer patientsFresh tumor samplesIGF-I expressionIGF-I mRNAOvarian cancer progressionEnzyme-linked immunosorbentParacrine/autocrineTotal IGFFree IGFClinicopathologic featuresCA polymorphismCancer patientsReal-time PCRElevated risk
2006
Specimen processing time and measurement of total insulin-like growth factor-I (IGF-I), free IGF-I, and IGF binding protein-3 (IGFBP-3)
Harris T, Strickler H, Yu H, Pollak M, Monrad E, Travin M, Xue X, Rohan T, Kaplan R. Specimen processing time and measurement of total insulin-like growth factor-I (IGF-I), free IGF-I, and IGF binding protein-3 (IGFBP-3). Growth Hormone & IGF Research 2006, 16: 86-92. PMID: 16530441, DOI: 10.1016/j.ghir.2006.01.002.Peer-Reviewed Original ResearchConceptsFree IGF-I levelsIGF-I levelsInsulin-like growth factorTotal IGFIGFBP-3 levelsFree IGFIGFBP-3Blood specimensBlood collectionEpidemiologic studiesTotal insulin-like growth factorSerum separation tubesGrowth factorRisk of cancerEquation linear regression modelsSerum levelsCardiovascular diseaseMajor binding proteinSerum valuesIGFCommercial assaysIGFBPSpecimen processing timeProtein 3Immunosorbent assay
2001
Free insulin‐like growth factor‐I and breast cancer risk
Li B, Khosravi M, Berkel H, Diamandi A, Dayton M, Smith M, Yu H. Free insulin‐like growth factor‐I and breast cancer risk. International Journal Of Cancer 2001, 91: 736-739. PMID: 11267989, DOI: 10.1002/1097-0215(200002)9999:9999<::aid-ijc1111>3.0.co;2-#.Peer-Reviewed Original ResearchConceptsIGF-I receptorInsulin-like growth factorFree IGFIGFBP-3Action of IGFBreast cancer patientsTotal IGFBreast cancer riskBreast cancerIGF-IICancer patientsPlasma levelsCancer riskFree insulin-like growth factorRace-matched healthy controlsFree IGF-I levelsConditional logistic regression analysisGrowth factorIGF-I levelsIGF binding proteinBinding of IGFHigher plasma levelsLogistic regression analysisHigher plasma IGFAnti-apoptotic effects