2023
Association between use of antihypertensive drugs and the risk of cancer: a population-based cohort study in Shanghai
Wang S, Xie L, Zhuang J, Qian Y, Zhang G, Quan X, Li L, Yu H, Zhang W, Zhao W, Qian B. Association between use of antihypertensive drugs and the risk of cancer: a population-based cohort study in Shanghai. BMC Cancer 2023, 23: 425. PMID: 37165412, PMCID: PMC10173582, DOI: 10.1186/s12885-023-10849-8.Peer-Reviewed Original ResearchConceptsPopulation-based cohort studyTotal cancerAntihypertensive drugsHypertensive patientsCohort studyAntihypertensive medicinesThyroid cancerHigh riskPossible dose-response relationshipAntihypertensive drug administrationCommon antihypertensive drugsRisk of cancerCommunity healthcare centersDose-response relationshipMajor cancer typesAntihypertensive classesCancer casesMAIN OUTCOMECancer riskHealthcare centersDrug AdministrationPatientsSignificant associationCancerCancer types
2010
Association of genetic polymorphisms in DNA repair pathway genes with non-small cell lung cancer risk
Qian B, Zhang H, Zhang L, Zhou X, Yu H, Chen K. Association of genetic polymorphisms in DNA repair pathway genes with non-small cell lung cancer risk. Lung Cancer 2010, 73: 138-146. PMID: 21195504, DOI: 10.1016/j.lungcan.2010.11.018.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overCarcinoma, Non-Small-Cell LungDNA RepairDNA Repair EnzymesDNA-Binding ProteinsFemaleGenetic Association StudiesGenetic Predisposition to DiseaseHumansLung NeoplasmsMaleMiddle AgedPolymorphism, GeneticRisk FactorsSmokingXeroderma Pigmentosum Group A ProteinXeroderma Pigmentosum Group D ProteinYoung AdultConceptsNon-small cell lung cancerLung cancer riskSquamous cell carcinomaLung cancerCancer riskCell carcinomaSingle nucleotide polymorphismsHigh riskGenetic polymorphismsNon-small cell lung cancer riskRisk of NSCLCCell lung cancer riskHigher lung cancer riskCell lung cancerVariant AA genotypeDominant risk factorNumerous epidemiological studiesLogistic regression modelsDNA repair pathway genesYoung smokersNSCLC casesSubgroup analysisRisk factorsHealthy controlsStratified analysis
2004
Evaluation of the synergistic effect of insulin resistance and insulin‐like growth factors on the risk of breast carcinoma
Malin A, Dai Q, Yu H, Shu X, Jin F, Gao Y, Zheng W. Evaluation of the synergistic effect of insulin resistance and insulin‐like growth factors on the risk of breast carcinoma. Cancer 2004, 100: 694-700. PMID: 14770423, PMCID: PMC1780270, DOI: 10.1002/cncr.20023.Peer-Reviewed Original ResearchConceptsInsulin-like growth factorBreast carcinomaC-peptideIGFBP-3Insulin resistanceIGF-1Odds ratioShanghai Breast Cancer StudyGrowth factorBreast carcinoma riskHigh blood levelsBreast carcinoma casesCase-control pairsDose-response mannerBreast Cancer StudyCurrent studyHighest quartileBlood levelsLowest quartileCarcinoma casesCarcinoma riskHigh riskHigh levelsCarcinomaSignificant twofold
1999
Do insulin-like growth factors mediate the effect of alcohol on breast cancer risk?
Yu H, Berkel J. Do insulin-like growth factors mediate the effect of alcohol on breast cancer risk? Medical Hypotheses 1999, 52: 491-496. PMID: 10459827, DOI: 10.1054/mehy.1998.0828.Peer-Reviewed Original ResearchConceptsInsulin-like growth factorBreast cancer riskBreast cancerEffects of alcoholIGF productionCancer riskElevated insulin-like growth factorHeavy drinkersGrowth factorDose-response relationshipHeavy alcohol usersAlcohol intakeEpidemiologic studiesHigh riskModerate drinkersAlcohol consumptionModerate consumptionAlcohol usersCancerDrinkersRiskModest increaseBiological mechanismsAssociationBiological role
1996
Creatine kinase BB isoenzyme levels in tumour cytosols and survival of breast cancer patients
Zarghami N, Giai M, Yu H, Roagna R, Ponzone R, Katsaros D, Sismondi P, Diamandis E. Creatine kinase BB isoenzyme levels in tumour cytosols and survival of breast cancer patients. British Journal Of Cancer 1996, 73: 386-390. PMID: 8562347, PMCID: PMC2074443, DOI: 10.1038/bjc.1996.66.Peer-Reviewed Original ResearchConceptsCK-BB levelsCK-BBTumor cytosolsEstrogen receptor-negative cancersEstrogen receptor-positive tumorsReceptor-positive tumorsBreast cancer patientsRisk of deathReceptor-negative cancersRisk of relapseBreast tumor cytosolsHistological typeClinicopathological variablesPatient survivalPrognostic indicatorTumor stageAggressive tumorsCancer patientsProgesterone receptorUnivariate analysisHigh riskBB groupIsoenzyme levelsPatientsBreast tumors