2006
High eIF4E, VEGF, and Microvessel Density in Stage I to III Breast Cancer
Byrnes K, White S, Chu Q, Meschonat C, Yu H, Johnson L, DeBenedetti A, Abreo F, Turnage R, McDonald J, Li B. High eIF4E, VEGF, and Microvessel Density in Stage I to III Breast Cancer. Annals Of Surgery 2006, 243: 684-692. PMID: 16633004, PMCID: PMC1570543, DOI: 10.1097/01.sla.0000216770.23642.d8.Peer-Reviewed Original ResearchConceptsVascular endothelial growth factorCancer-related deathWorse clinical outcomesBreast cancer patientsHigh eIF4E overexpressionMicrovessel densityEIF4E overexpressionCancer specimensHigh eIF4ENodal statusClinical outcomesVEGF elevationMVD countCancer patientsCancer recurrenceBreast cancerStage IShorter disease-free survivalClinical surveillance protocolLow eIF4E overexpressionDisease-free survivalHighest cancer-related deathsHigher VEGF levelsTumor microvessel densityBreast cancer specimens
2002
Prospective Study of Eukaryotic Initiation Factor 4E Protein Elevation and Breast Cancer Outcome
Li B, Gruner J, Abreo F, Johnson L, Yu H, Nawas S, McDonald J, DeBenedetti A. Prospective Study of Eukaryotic Initiation Factor 4E Protein Elevation and Breast Cancer Outcome. Annals Of Surgery 2002, 235: 732-739. PMID: 11981220, PMCID: PMC1422500, DOI: 10.1097/00000658-200205000-00016.Peer-Reviewed Original ResearchConceptsCancer-related deathCancer recurrenceRelative riskBreast cancerIndependent predictorsReceptor statusProtein elevationHigh eIF4EMenopausal statusTumor sizeTumor gradeHigher cancer recurrence rateImportant independent prognostic markerKaplan-Meier survival curvesCox proportional hazards modelStage 1Progesterone receptor statusBreast cancer outcomesSmall retrospective studiesStage of diseaseEstrogen receptor statusCancer recurrence rateIndependent prognostic markerLog-rank testBreast cancer recurrence