2012
Large Scale Association Analysis for Drug Addiction: Results from SNP to Gene
Guo X, Liu Z, Wang X, Zhang H. Large Scale Association Analysis for Drug Addiction: Results from SNP to Gene. The Scientific World JOURNAL 2012, 2012: 939584. PMID: 23365539, PMCID: PMC3543790, DOI: 10.1100/2012/939584.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesAssociation studiesAssociation analysisGene-based association analysisLarge-scale association analysisSingle nucleotide polymorphism dataWide association studyComplex diseasesGene-based analysisGene-based methodsNucleotide polymorphism dataGenetic association studiesPolymorphism dataGene findingGenetic variantsIndividual SNPsStudy of AddictionSNPsGenetic etiologyGenesComprehensive analysisGeneticsVariants
2008
LOT: a tool for linkage analysis of ordinal traits for pedigree data
Zhang M, Feng R, Chen X, Hu B, Zhang H. LOT: a tool for linkage analysis of ordinal traits for pedigree data. Bioinformatics 2008, 24: 1737-1739. PMID: 18535081, PMCID: PMC2566542, DOI: 10.1093/bioinformatics/btn258.Peer-Reviewed Original Research
2006
Family‐based association tests for ordinal traits adjusting for covariates
Wang X, Ye Y, Zhang H. Family‐based association tests for ordinal traits adjusting for covariates. Genetic Epidemiology 2006, 30: 728-736. PMID: 17086513, DOI: 10.1002/gepi.20184.Peer-Reviewed Original Research
2005
Multivariate linkage analysis using the electrophysiological phenotypes in the COGA alcoholism data
Zhang H, Zhong X, Ye Y. Multivariate linkage analysis using the electrophysiological phenotypes in the COGA alcoholism data. BMC Genomic Data 2005, 6: s118. PMID: 16451575, PMCID: PMC1866820, DOI: 10.1186/1471-2156-6-s1-s118.Peer-Reviewed Original ResearchLinkage analysis and association analysis in the presence of linkage using age at onset of COGA alcoholism data
Zhong X, Zhang H. Linkage analysis and association analysis in the presence of linkage using age at onset of COGA alcoholism data. BMC Genomic Data 2005, 6: s31. PMID: 16451641, PMCID: PMC1866754, DOI: 10.1186/1471-2156-6-s1-s31.Peer-Reviewed Original ResearchConceptsLinkage analysisAssociation analysisSusceptibility genesGenetic Analysis Workshop 14Alcoholism dataCombination of linkageComplex disease mappingDisease susceptibility genesEntire genomeMean identityLinkage disequilibriumTransmission/disequilibrium testAssociation TestGenesPresence of linkageDisequilibrium testGenomeChromosomesGeneticsLinkageDisequilibriumAssociation strategyGreater numberRegionData mining
Cupples LA, Bailey J, Cartier KC, Falk CT, Liu K, Ye Y, Yu R, Zhang H, Zhao H. Data mining. Genetic Epidemiology 2005, 29: s103-s109. PMID: 16342179, DOI: 10.1002/gepi.20117.Peer-Reviewed Original ResearchMeSH KeywordsAlcoholismArtificial IntelligenceChromosome MappingCytogenetic AnalysisDecision TreesGenetic MarkersHaplotypesHumansNeural Networks, ComputerComparison of single‐nucleotide polymorphisms and microsatellite markers for linkage analysis in the COGA and simulated data sets for Genetic Analysis Workshop 14: Presentation Groups 1, 2, and 3
Wilcox MA, Pugh EW, Zhang H, Zhong X, Levinson DF, Kennedy GC, Wijsman EM. Comparison of single‐nucleotide polymorphisms and microsatellite markers for linkage analysis in the COGA and simulated data sets for Genetic Analysis Workshop 14: Presentation Groups 1, 2, and 3. Genetic Epidemiology 2005, 29: s7-s28. PMID: 16342186, DOI: 10.1002/gepi.20106.Peer-Reviewed Original Research
2001
Tree‐Based Linkage and Association Analyses of Asthma
Zhang H, Tsai C, Yu C, Bonney G. Tree‐Based Linkage and Association Analyses of Asthma. Genetic Epidemiology 2001, 21: s317-s322. PMID: 11793691, DOI: 10.1002/gepi.2001.21.s1.s317.Peer-Reviewed Original Research
1997
Cost-effective sib-pair designs in the mapping of quantitative-trait loci.
Zhao H, Zhang H, Rotter JI. Cost-effective sib-pair designs in the mapping of quantitative-trait loci. American Journal Of Human Genetics 1997, 60: 1211-21. PMID: 9150169, PMCID: PMC1712450.Peer-Reviewed Original ResearchStrategies to Identify Genes for Complex Diseases
Zhang H, Zhao H, Merikangas K. Strategies to Identify Genes for Complex Diseases. Annals Of Medicine 1997, 29: 493-498. PMID: 9562515, DOI: 10.3109/07853899709007473.Peer-Reviewed Original ResearchConceptsComplex diseasesNumerous human diseasesDisease-susceptible genesComplex human disordersHuman genomeGenetic basisHuman disordersHuman diseasesMolecular biologyGenesGenetic epidemiological studiesGenetic factorsComplex patternsDisease pathophysiologyGenomeBiologyTraitsInheritanceMultiple sclerosisBreast cancerEpidemiological studies
1996
Mapping quantitative-trait loci in humans by use of extreme concordant sib pairs: selected sampling by parental phenotypes.
Zhang H, Risch N. Mapping quantitative-trait loci in humans by use of extreme concordant sib pairs: selected sampling by parental phenotypes. American Journal Of Human Genetics 1996, 59: 951-7. PMID: 8808613, PMCID: PMC1914798.Peer-Reviewed Original ResearchMapping quantitative trait loci with extreme discordant sib pairs: sampling considerations.
Risch N, Zhang H. Mapping quantitative trait loci with extreme discordant sib pairs: sampling considerations. American Journal Of Human Genetics 1996, 58: 836-43. PMID: 8644748, PMCID: PMC1914664.Peer-Reviewed Original Research
1995
Extreme Discordant Sib Pairs for Mapping Quantitative Trait Loci in Humans
Risch N, Zhang H. Extreme Discordant Sib Pairs for Mapping Quantitative Trait Loci in Humans. Science 1995, 268: 1584-1589. PMID: 7777857, DOI: 10.1126/science.7777857.Peer-Reviewed Original Research