2015
Chlamydia trachomatis immunoglobulin G3 seropositivity is a predictor of reproductive outcomes in infertile women with patent fallopian tubes
Steiner AZ, Diamond MP, Legro RS, Schlaff WD, Barnhart KT, Casson PR, Christman GM, Alvero R, Hansen KR, Geisler WM, Thomas T, Santoro N, Zhang H, Eisenberg E, Network R. Chlamydia trachomatis immunoglobulin G3 seropositivity is a predictor of reproductive outcomes in infertile women with patent fallopian tubes. Fertility And Sterility 2015, 104: 1522-1526. PMID: 26413816, PMCID: PMC4663111, DOI: 10.1016/j.fertnstert.2015.08.022.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAntibodies, BacterialBiomarkersChi-Square DistributionChlamydia InfectionsChlamydia trachomatisEnzyme-Linked Immunosorbent AssayFallopian TubesFemaleHumansImmunoglobulin GInfertility, FemaleLinear ModelsLive BirthMultivariate AnalysisOdds RatioPredictive Value of TestsPregnancyPregnancy RatePregnancy, EctopicReproductive Techniques, AssistedRisk AssessmentRisk FactorsSerologic TestsTreatment OutcomeUltrasonographyYoung AdultConceptsEctopic pregnancySeropositive womenInfertile womenTubal patencyLive birthsPolycystic Ovary Syndrome IIChlamydia trachomatis seropositivityMultiple Intrauterine GestationsPatent fallopian tubesEnzyme-linked immunosorbentCurrent alcohol useC. trachomatis elementary bodiesOvarian stimulationCohort studyIntrauterine gestationPregnancy outcomesPrimary outcomeTreatment medicationsPatent tubesSmoking statusOutpatient clinicIgG3 antibodiesFallopian tubeRelative riskMAIN OUTCOMEPredictors of participant retention in infertility treatment trials
Kuang H, Jin S, Thomas T, Engmann L, Hansen KR, Coutifaris C, Casson P, Christman G, Alvero R, Santoro N, Eisenberg E, Diamond MP, Legro RS, Zhang H, Network R, Bartlebaugh C, Dodson W, Estes S, Gnatuk C, Ladda R, Ober J, Easton C, Hernandez A, Leija M, Pierce D, Bryzski R, Awonuga A, Cedo L, Cline A, Collins K, Krawetz S, Puscheck E, Singh M, Yoscovits M, Barnhart K, Lecks K, Martino L, Marunich R, Snyder P, Schlaff W, Comfort A, Crow M, Hohmann A, Mallette S, Ringbloom M, Tang J, Mason S, DiMaria N, Rhea M, Turner K, Haisenleder D, Trussell J, DelBasso D, Li Y, Makuch R, Patrizio P, Sakai L, Scahill L, Taylor H, Thomas T, Tsang S, Zhang M, Lamar C, DePaolo L, Guzick D, Herring A, Redmond J, Thomas M, Turek P, Wactawski-Wende J, Rebar R, Cato P, Dukic V, Lewis V, Schlegel P, Witter F. Predictors of participant retention in infertility treatment trials. Fertility And Sterility 2015, 104: 1236-1243.e2. PMID: 26354094, PMCID: PMC4630082, DOI: 10.1016/j.fertnstert.2015.08.001.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAdolescentAdultChi-Square DistributionDrug Therapy, CombinationFemaleFertilityFertility Agents, FemaleHumansInfertility, FemaleLogistic ModelsMaleMultivariate AnalysisOdds RatioPatient DropoutsPatient SelectionPolycystic Ovary SyndromePregnancyRandomized Controlled Trials as TopicRisk FactorsTreatment OutcomeYoung AdultConceptsPolycystic ovary syndromeBody mass indexClomiphene citrateClinical trialsHistory of smokingInsurance coverageCombination of metforminMultivariable logistic modelAcademic medical centerRetention of subjectsConduct of RCTsBetter insurance coverageUnexplained infertilityOvary syndromeNormal weightMass indexOriginal RCTTreatment trialsMedical CenterMAIN OUTCOMEWhite raceIntervention studiesRCTsSecondary analysisParticipant retention
2014
TARV: Tree‐based Analysis of Rare Variants Identifying Risk Modifying Variants in CTNNA2 and CNTNAP2 for Alcohol Addiction
Song C, Zhang H. TARV: Tree‐based Analysis of Rare Variants Identifying Risk Modifying Variants in CTNNA2 and CNTNAP2 for Alcohol Addiction. Genetic Epidemiology 2014, 38: 552-559. PMID: 25041903, PMCID: PMC4154634, DOI: 10.1002/gepi.21843.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesSequence kernel association testRare variant dataTree-based analysisRare variantsNext-generation sequencing technologiesVariant dataGeneration sequencing technologyKernel association testGene-gene interactionsSequencing technologiesMultiple genesAssociation studiesDisease modelsRisk genesCTNNA2Genetic variantsSAGE dataComplex disease modelsGenesStudy of AddictionComplex diseasesCommon variantsSpecific variantsRisk of alcoholism
2013
NCK2 Is Significantly Associated with Opiates Addiction in African‐Origin Men
Liu Z, Guo X, Jiang Y, Zhang H. NCK2 Is Significantly Associated with Opiates Addiction in African‐Origin Men. The Scientific World JOURNAL 2013, 2013: 748979. PMID: 23533358, PMCID: PMC3603435, DOI: 10.1155/2013/748979.Peer-Reviewed Original ResearchConceptsSingle nucleotide polymorphismsNCK2 geneGenome-wide significant associationGenome-wide significant levelWide association studyGene-based methodsNumerous genetic variantsGWAS discoveryChromosome 2Association studiesNck2Genetic variantsGenesNucleotide polymorphismsComplex diseasesFirst evidenceGenetic disordersDiscoverySignificant levelsPolymorphismVariantsSubstantial effort
2012
Genetic Association Test for Multiple Traits at Gene Level
Guo X, Liu Z, Wang X, Zhang H. Genetic Association Test for Multiple Traits at Gene Level. Genetic Epidemiology 2012, 37: 122-129. PMID: 23032486, PMCID: PMC3524409, DOI: 10.1002/gepi.21688.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesMultiple traitsGene levelSingle nucleotide polymorphismsGenetic association testsCommon genesAssociation studiesAssociation TestNucleotide polymorphismsTraitsStudy of AddictionComplex diseasesBiological mechanismsDisease of interestAssociation informationGenesGeneticsSuch studiesStrong evidencePolymorphismPrevious findingsLevels
2007
Correlating observed odds ratios from lung cancer case–control studies to SNP functional scores predicted by bioinformatic tools
Zhu Y, Hoffman A, Wu X, Zhang H, Zhang Y, Leaderer D, Zheng T. Correlating observed odds ratios from lung cancer case–control studies to SNP functional scores predicted by bioinformatic tools. Mutation Research/Fundamental And Molecular Mechanisms Of Mutagenesis 2007, 639: 80-88. PMID: 18191955, PMCID: PMC2292456, DOI: 10.1016/j.mrfmmm.2007.11.005.Peer-Reviewed Original Research
2003
Longitudinal Trajectories of Depression and Anxiety in a Prospective Community Study: The Zurich Cohort Study
Merikangas KR, Zhang H, Avenevoli S, Acharyya S, Neuenschwander M, Angst J. Longitudinal Trajectories of Depression and Anxiety in a Prospective Community Study: The Zurich Cohort Study. JAMA Psychiatry 2003, 60: 993-1000. PMID: 14557144, DOI: 10.1001/archpsyc.60.9.993.Peer-Reviewed Original ResearchConceptsComorbid anxietyDiagnostic thresholdZurich cohort studyLong-term followCommunity-based cohortMajor mental disordersProspective community studyCommunity-based sampleCohort studyProspective studyComorbid statesAffective disordersMental disordersDiagnostic InterviewMid adulthoodCanton of ZurichCommunity studyAnxiety statesSubthreshold levelsAssessment pointsDepressionDisordersLongitudinal trajectoriesTreatment researchAnxiety
2001
Socioeconomic status and type 2 diabetes in African American and non-Hispanic white women and men: evidence from the Third National Health and Nutrition Examination Survey
Robbins JM, Vaccarino V, Zhang H, Kasl SV. Socioeconomic status and type 2 diabetes in African American and non-Hispanic white women and men: evidence from the Third National Health and Nutrition Examination Survey. American Journal Of Public Health 2001, 91: 76-83. PMID: 11189829, PMCID: PMC1446485, DOI: 10.2105/ajph.91.1.76.Peer-Reviewed Original ResearchConceptsPoverty income ratioType 2 diabetes prevalenceNon-Hispanic white womenNutrition Examination SurveyThird National HealthDiabetes prevalenceRisk factorsAfrican American womenWhite womenExamination SurveyNational HealthSocioeconomic statusPrevalence of diabetesType 2 diabetesAmerican womenAfrican American menOccupational statusDiabetesSignificant associationPrevalenceWhite menCross-sectional dataWomenAmerican menMen
2000
Excess type 2 diabetes in African-American women and men aged 40–74 and socioeconomic status: evidence from the Third National Health and Nutrition Examination Survey
Robbins JM, Vaccarino V, Zhang H, Kasl SV. Excess type 2 diabetes in African-American women and men aged 40–74 and socioeconomic status: evidence from the Third National Health and Nutrition Examination Survey. Journal Of Epidemiology & Community Health 2000, 54: 839. PMID: 11027198, PMCID: PMC1731578, DOI: 10.1136/jech.54.11.839.Peer-Reviewed Original ResearchConceptsType 2 diabetesAfrican American race/ethnicityNon-Hispanic white womenRace/ethnicityNutrition Examination SurveyAfrican American womenThird National HealthRisk factorsOdds ratioSocioeconomic statusDiabetes prevalenceExamination SurveyPhysical examinationNational HealthType 2 diabetes prevalenceWhite womenNon-Hispanic white menMobile examination centerPoverty income ratioAfrican American menExcess prevalenceSectional studyExamination centerSubjects' homesDiabetes
1999
Psychosocial and Clinical Correlates of ADHD in a Community Sample of School-Age Children
SCAHILL L, SCHWAB-STONE M, MERIKANGAS K, LECKMAN J, ZHANG H, KASL S. Psychosocial and Clinical Correlates of ADHD in a Community Sample of School-Age Children. Journal Of The American Academy Of Child & Adolescent Psychiatry 1999, 38: 976-984. PMID: 10434489, DOI: 10.1097/00004583-199908000-00013.Peer-Reviewed Original ResearchConceptsAttention deficit hyperactivity disorderADHD groupCommunity sampleFamily dysfunctionSubthreshold attention-deficit hyperactivity disorderGlobal Assessment ScaleDisruptive behavior disordersChildren's Global Assessment ScaleStructured diagnostic interviewPsychiatric comorbiditySchool-aged childrenADHD statusHyperactivity disorderPsychosocial adversityExcessive alcohol useDimensional approachDiagnostic InterviewLow-income familiesAlcohol useBehavior disorderClinical correlatesSubthreshold groupChildrenAssessment ScalePsychiatric treatment