2018
Evaluation, validation and refinement of noninvasive diagnostic biomarkers for endometriosis (ENDOmarker): A protocol to phenotype bio-specimens for discovery and validation
Barnhart K, Giudice L, Young S, Thomas T, Diamond MP, Segars J, Youssef WA, Krawetz S, Santoro N, Eisenberg E, Zhang H, Network F. Evaluation, validation and refinement of noninvasive diagnostic biomarkers for endometriosis (ENDOmarker): A protocol to phenotype bio-specimens for discovery and validation. Contemporary Clinical Trials 2018, 68: 1-6. PMID: 29524590, PMCID: PMC5899676, DOI: 10.1016/j.cct.2018.03.002.Peer-Reviewed Original ResearchMeSH KeywordsAdultBiomarkersConservative TreatmentCytokinesEndometriosisEndometriumFemaleGenitaliaHumansPhenotypeReproducibility of ResultsSpecimen HandlingConceptsReproductive Medicine NetworkDisease-specific questionnaireReproductive-aged womenTime of surgeryEstrogen-dependent conditionStage of endometriosisExtensive clinical evaluationSeverity of diseaseNoninvasive diagnostic biomarkersAcademic medical centerPelvic painEndometrial biopsyNonsurgical diagnosisSerum cytokinesSurgical ablationGynecologic surgeryClinical evaluationClinical reasonsMedical CenterAged womenPharmacological controlEndometriosisGenomic classifierSpecific questionnaireTherapy shifts
2012
Multiscale Adaptive Marginal Analysis of Longitudinal Neuroimaging Data with Time-Varying Covariates
Skup M, Zhu H, Zhang H. Multiscale Adaptive Marginal Analysis of Longitudinal Neuroimaging Data with Time-Varying Covariates. Biometrics 2012, 68: 1083-1092. PMID: 22551084, PMCID: PMC3767131, DOI: 10.1111/j.1541-0420.2012.01767.x.Peer-Reviewed Original ResearchGenome‐wide search for replicable risk gene regions in alcohol and nicotine co‐dependence
Zuo L, Zhang F, Zhang H, Zhang X, Wang F, Li C, Lu L, Hong J, Lu L, Krystal J, Deng H, Luo X. Genome‐wide search for replicable risk gene regions in alcohol and nicotine co‐dependence. American Journal Of Medical Genetics Part B Neuropsychiatric Genetics 2012, 159B: 437-444. PMID: 22488850, PMCID: PMC3405545, DOI: 10.1002/ajmg.b.32047.Peer-Reviewed Original ResearchConceptsChromosome 3Genome-wide false discovery rateGene regionFalse discovery rateGenome-wide association analysisExpression quantitative trait loci (eQTL) analysisQuantitative trait locus (QTL) analysisRisk SNPsTranscript expressionGenome-wide association strategyGenome-wide searchCombined P valueSNP-disease associationsAssociation peakGenomic regionsEQTL analysisEuropean American casesCausal lociLocus analysisGene expressionAssociation analysisGenesSNPsRegulatory effectsDiscovery rate
2006
Family‐based association tests for ordinal traits adjusting for covariates
Wang X, Ye Y, Zhang H. Family‐based association tests for ordinal traits adjusting for covariates. Genetic Epidemiology 2006, 30: 728-736. PMID: 17086513, DOI: 10.1002/gepi.20184.Peer-Reviewed Original ResearchA statistical framework for the classification of tensor morphologies in diffusion tensor images
Zhu H, Xu D, Raz A, Hao X, Zhang H, Kangarlu A, Bansal R, Peterson BS. A statistical framework for the classification of tensor morphologies in diffusion tensor images. Magnetic Resonance Imaging 2006, 24: 569-582. PMID: 16735178, PMCID: PMC2367261, DOI: 10.1016/j.mri.2006.01.004.Peer-Reviewed Original Research
2005
Localizing Value of Ictal–Interictal SPECT Analyzed by SPM (ISAS)
McNally KA, Paige AL, Varghese G, Zhang H, Novotny EJ, Spencer SS, Zubal IG, Blumenfeld H. Localizing Value of Ictal–Interictal SPECT Analyzed by SPM (ISAS). Epilepsia 2005, 46: 1450-1464. PMID: 16146441, DOI: 10.1111/j.1528-1167.2005.06705.x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBrain MappingElectroencephalographyEpilepsyEpilepsy, Temporal LobeFemaleFunctional LateralityHumansImage Processing, Computer-AssistedMaleMiddle AgedNeocortexPreoperative CareReproducibility of ResultsROC CurveTechnetium Tc 99m ExametazimeTomography, Emission-Computed, Single-PhotonVideotape RecordingConceptsStatistical parametric mappingIctal-interictal SPECTSeizure onsetMultiple brain regionsPostictal SPECTBrain regionsLateralized seizure onsetInterictal scansPostictal scansIctal SPECTDecreased perfusionSeizure endEpilepsy casesMesial temporalPerfusion increaseSPECT analysisSPECT scansSeizuresLocalized epilepsyParametric mappingTracer injectionSPECTInjectionPatientsEpilepsyComparison of single‐nucleotide polymorphisms and microsatellite markers for linkage analysis in the COGA and simulated data sets for Genetic Analysis Workshop 14: Presentation Groups 1, 2, and 3
Wilcox MA, Pugh EW, Zhang H, Zhong X, Levinson DF, Kennedy GC, Wijsman EM. Comparison of single‐nucleotide polymorphisms and microsatellite markers for linkage analysis in the COGA and simulated data sets for Genetic Analysis Workshop 14: Presentation Groups 1, 2, and 3. Genetic Epidemiology 2005, 29: s7-s28. PMID: 16342186, DOI: 10.1002/gepi.20106.Peer-Reviewed Original Research
2004
Correcting the loss of cell-cycle synchrony in clustering analysis of microarray data using weights
Duan F, Zhang H. Correcting the loss of cell-cycle synchrony in clustering analysis of microarray data using weights. Bioinformatics 2004, 20: 1766-1771. PMID: 15166015, DOI: 10.1093/bioinformatics/bth169.Peer-Reviewed Original ResearchAlgorithmsBiological ClocksCell CycleCluster AnalysisGene Expression ProfilingGene Expression Regulation, FungalModels, GeneticModels, StatisticalOligonucleotide Array Sequence AnalysisPattern Recognition, AutomatedReproducibility of ResultsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSensitivity and SpecificityTime Factors
2003
Development of the Yale Children’s Global Stress Index (YCGSI) and Its Application in Children and Adolescents With Tourette’s Syndrome and Obsessive-Compulsive Disorder
FINDLEY DB, LECKMAN JF, KATSOVICH L, LIN H, ZHANG H, GRANTZ H, OTKA J, LOMBROSO PJ, KING RA. Development of the Yale Children’s Global Stress Index (YCGSI) and Its Application in Children and Adolescents With Tourette’s Syndrome and Obsessive-Compulsive Disorder. Journal Of The American Academy Of Child & Adolescent Psychiatry 2003, 42: 450-457. PMID: 12649632, DOI: 10.1097/01.chi.0000046816.95464.ef.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderTourette syndromeDaily Life Stressors ScalePsychosocial stressAge-matched control subjectsClinician ratingsClinical rating instrumentGlobal clinician ratingsTime pointsGlobal Stress IndexCross-sectional ratingsEarly-onset obsessive-compulsive disorderPsychometric propertiesControl subjectsClinical severityObsessive-compulsive symptom severityStudy of childrenAcceptable psychometric propertiesStress indexSymptom severitySyndromePossible differential contributionInterrater reliabilityStressor ScaleDisorders
1997
Symptoms of obsessive-compulsive disorder
Leckman JF, Grice DE, Boardman J, Zhang H, Vitale A, Bondi C, Alsobrook J, Peterson BS, Cohen DJ, Rasmussen SA, Goodman WK, McDougle CJ, Pauls DL. Symptoms of obsessive-compulsive disorder. American Journal Of Psychiatry 1997, 154: 911-917. PMID: 9210740, DOI: 10.1176/ajp.154.7.911.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderMultiple psychological domainsYale-Brown Obsessive Compulsive Scale Symptom ChecklistTypes of obsessionsCompulsive Scale Symptom ChecklistSocial relatednessPsychological domainSymptom dimensionsPrincipal component factor analysisCorrelational relationshipsSymptom ChecklistDiverse motor behaviorsMotor behaviorFactor analysisExploratory analysisVarimax rotationTreatment response studiesObsessionDisordersIndependent groupsEmotionsCognitionPerceptionSymptomsCompulsion
1996
A TREE‐BASED METHOD OF ANALYSIS FOR PROSPECTIVE STUDIES
ZHANG H, HOLFORD T, BRACKEN M. A TREE‐BASED METHOD OF ANALYSIS FOR PROSPECTIVE STUDIES. Statistics In Medicine 1996, 15: 37-49. PMID: 8614744, DOI: 10.1002/(sici)1097-0258(19960115)15:1<37::aid-sim144>3.0.co;2-0.Peer-Reviewed Original Research