2013
Rare SERINC2 variants are specific for alcohol dependence in individuals of European descent
Zuo L, Wang KS, Zhang XY, Li CS, Zhang F, Wang X, Chen W, Gao G, Zhang H, Krystal JH, Luo X. Rare SERINC2 variants are specific for alcohol dependence in individuals of European descent. Pharmacogenetics And Genomics 2013, 23: 395-402. PMID: 23778322, PMCID: PMC4287355, DOI: 10.1097/fpc.0b013e328362f9f2.Peer-Reviewed Original Research
2011
Regression and data mining methods for analyses of multiple rare variants in the Genetic Analysis Workshop 17 mini‐exome data
Bailey‐Wilson J, Brennan JS, Bull SB, Culverhouse R, Kim Y, Jiang Y, Jung J, Li Q, Lamina C, Liu Y, Mägi R, Niu YS, Simpson CL, Wang L, Yilmaz YE, Zhang H, Zhang Z. Regression and data mining methods for analyses of multiple rare variants in the Genetic Analysis Workshop 17 mini‐exome data. Genetic Epidemiology 2011, 35: s92-s100. PMID: 22128066, PMCID: PMC3360949, DOI: 10.1002/gepi.20657.Peer-Reviewed Original ResearchConceptsData mining methodsUse of machineMachine learning methodsMining methodsLearning methodsNovel methodGenetic Analysis Workshop 17 mini-exome dataGenetic Analysis Workshop 17Extreme locus heterogeneityDNA sequence dataLocus-specific heritabilityMultiple rare variantsPopulation-specific analysesRare variantsIndividual rare variantsRare genetic variantsRare causal variantsSubset of predictorsLarge numberMultiple variantsComplex traitsMachineSequence dataCausal variantsCausal mutations
2010
Total Testosterone Assays in Women with Polycystic Ovary Syndrome: Precision and Correlation with Hirsutism
Legro RS, Schlaff WD, Diamond MP, Coutifaris C, Casson PR, Brzyski RG, Christman GM, Trussell JC, Krawetz SA, Snyder PJ, Ohl D, Carson SA, Steinkampf MP, Carr BR, McGovern PG, Cataldo NA, Gosman GG, Nestler JE, Myers ER, Santoro N, Eisenberg E, Zhang M, Zhang H. Total Testosterone Assays in Women with Polycystic Ovary Syndrome: Precision and Correlation with Hirsutism. The Journal Of Clinical Endocrinology & Metabolism 2010, 95: 5305-5313. PMID: 20826578, PMCID: PMC2999971, DOI: 10.1210/jc.2010-1123.Peer-Reviewed Original ResearchConceptsTestosterone levelsLC/MS assayFerriman-Gallwey hirsutism scoreTotal testosterone levelsPolycystic ovary syndromeLow testosterone levelsMedian testosterone levelsEndocrine Society Position StatementBaseline testosterone levelsBlinded laboratory studyTotal testosterone assayHirsutism scoreInfertility trialsMS assayOvary syndromeTotal testosteroneHealth centersMAIN OUTCOMETestosterone RIAAcademic health centersTestosterone assaysDirect RIALC/MSPosition statementRIA
2009
Machine learning in genome‐wide association studies
Szymczak S, Biernacka JM, Cordell HJ, González‐Recio O, König IR, Zhang H, Sun YV. Machine learning in genome‐wide association studies. Genetic Epidemiology 2009, 33: s51-s57. PMID: 19924717, DOI: 10.1002/gepi.20473.Peer-Reviewed Original ResearchConceptsGenome-wide SNP dataSingle nucleotide polymorphismsSNP dataAssociation studiesGenome-wide association studiesOverall genetic architectureMachine learning approachesGenetic Analysis Workshop 16Wide association studyComplex human diseasesMain genetic effectsGenetic architectureLearning approachGenetic risk variantsEnsemble methodHuman diseasesGenetic effectsRisk variantsGenetic variantsComplex diseasesMachineNew variable selection procedureNetwork analysisVariable selection procedureDifferent approaches
2003
Disruptive Behavior in Children With Tourette's Syndrome: Association With ADHD Comorbidity, Tic Severity, and Functional Impairment
SUKHODOLSKY DG, SCAHILL L, ZHANG H, PETERSON BS, KING RA, LOMBROSO PJ, KATSOVICH L, FINDLEY D, LECKMAN JF. Disruptive Behavior in Children With Tourette's Syndrome: Association With ADHD Comorbidity, Tic Severity, and Functional Impairment. Journal Of The American Academy Of Child & Adolescent Psychiatry 2003, 42: 98-105. PMID: 12500082, DOI: 10.1097/00004583-200301000-00016.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderComorbid attention-deficit/hyperactivity disorderDisruptive behaviorFamily functioningParent ratingsTeacher ratingsDiagnosis of ADHDVineland Adaptive Behavior ScalesDisruptive behavior problemsHierarchical regression analysisAdaptive Behavior ScalesBest-estimate DSM-IV diagnosesUnaffected control childrenTourette syndromeConduct problemsDelinquency scoresHyperactivity disorderADHD comorbidityDelinquent behaviorBehavior problemsDSM-IV diagnosisDependent measuresDiagnostic statusBehavior ScaleFunctional impairment
1999
Binary Regression for Risks in Excess of Subject-Specific Thresholds
Zhang H, Zelterman D. Binary Regression for Risks in Excess of Subject-Specific Thresholds. Biometrics 1999, 55: 1247-1251. PMID: 11315077, DOI: 10.1111/j.0006-341x.1999.01247.x.Peer-Reviewed Original Research