2007
Polymorphisms of one-carbon-metabolizing genes and risk of breast cancer in a population-based study
Xu X, Gammon M, Zhang H, Wetmur J, Rao M, Teitelbaum S, Britton J, Neugut A, Santella R, Chen J. Polymorphisms of one-carbon-metabolizing genes and risk of breast cancer in a population-based study. Carcinogenesis 2007, 28: 1504-1509. PMID: 17372271, DOI: 10.1093/carcin/bgm061.Peer-Reviewed Original ResearchConceptsOne-carbon metabolismRate-limiting enzymeThymidylate synthaseRate-limiting genesOne-carbon pathwayDNA methylationEpigenetic processesSame pathwayGenesMethylenetetrahydrofolate reductaseDNA synthesisEnzymePathwayCritical rolePolymorphismSame populationCancer etiologyPopulation-based Long Island Breast Cancer Study ProjectMetabolismFunctional polymorphismsRepeat alleleMethylationReductaseAllelesSynthase
2000
Use of classification trees for association studies
Zhang H, Bonney G. Use of classification trees for association studies. Genetic Epidemiology 2000, 19: 323-332. PMID: 11108642, DOI: 10.1002/1098-2272(200012)19:4<323::aid-gepi4>3.0.co;2-5.Peer-Reviewed Original Research