2007
A score test for linkage analysis of ordinal traits based on IBD sharing
Feng R, Zhang H. A score test for linkage analysis of ordinal traits based on IBD sharing. Biostatistics 2007, 9: 114-127. PMID: 17519391, DOI: 10.1093/biostatistics/kxm016.Peer-Reviewed Original Research
2006
Generalized score test of homogeneity for mixed effects models
Zhu H, Zhang H. Generalized score test of homogeneity for mixed effects models. The Annals Of Statistics 2006, 34: 1545-1569. DOI: 10.1214/009053606000000380.Peer-Reviewed Original ResearchTest statisticsAsymptotic distributionRandom quadratic formsGeneralized score testQuadratic formInvariance principleScore testTest of homogeneityLatent variable modelsSimulation studyResampling procedureRestrictive assumptionsEmpirical performanceHomogeneity hypothesisTheoretical resultsVariance componentsVariable modelTest procedureBiomedical studiesMild conditionsInvarianceOverdispersionImportant problemsAssumptionsObservational data
2003
A Latent Variable Model of Segregation Analysis for Ordinal Traits
Zhang H, Feng R, Zhu H. A Latent Variable Model of Segregation Analysis for Ordinal Traits. Journal Of The American Statistical Association 2003, 98: 1023-1034. DOI: 10.1198/016214503000000981.Peer-Reviewed Original ResearchDichotomous traitsLatent variable modelsAsymptotic theoryModel of segregation analysisFamilial transmission of alcoholismGene-environment interactionsAssessed familial aggregationConduct simulation studiesGenetic epidemiologySegregation analysisTransmission of alcoholismHealth conditionsOrdinal traitsFamilial aggregationBinary traitsVariable modelComplex genetic basisInheritance of diseaseStatistical inferenceEM algorithmEnvironmental factorsSimulation studyPsychiatric disordersGene componentsAlcohol abuse