2015
An analysis of moderators in the COMBINE study: Identifying subgroups of patients who benefit from acamprosate
Gueorguieva R, Wu R, Tsai WM, O’Connor P, Fucito L, Zhang H, O’Malley S. An analysis of moderators in the COMBINE study: Identifying subgroups of patients who benefit from acamprosate. European Neuropsychopharmacology 2015, 25: 1586-1599. PMID: 26141511, PMCID: PMC4600651, DOI: 10.1016/j.euroneuro.2015.06.006.Peer-Reviewed Original ResearchConceptsAcamprosate effectHeavy drinkingShort abstinenceEnhanced treatment responseMonths of treatmentSubgroup of patientsBody mass indexDrug plasma levelsIdentification of subgroupsBetter prognosisLower BMIMass indexPlasma levelsGlutamatergic hyperactivityTreatment responseAcamprosateCOMBINE StudyPrior treatmentLarger studyConsecutive daysAbstinencePretreatment abstinenceTreatment effectsCognitive inefficiencySubgroups
2001
Thermal Sensitivity in Tourette Syndrome: Preliminary Report
Scahill L, Lombroso P, Mack G, Van Wattum P, Zhang H, Vitale A, Leckman J. Thermal Sensitivity in Tourette Syndrome: Preliminary Report. Perceptual And Motor Skills 2001, 92: 419-432. PMID: 11361302, DOI: 10.2466/pms.2001.92.2.419.Peer-Reviewed Original ResearchConceptsTourette syndromeSubgroup of patientsAge of onsetAdult male subjectsCurrent ageTic symptomsDopaminergic pathwaysSex distributionCurrent severityMale subjectsMean differenceSyndromeControl periodPreliminary reportSweat rateAgeSymptomsSubjectsOverall courseDegrees COnsetPatientsIllnessSeverityCourse