2020
Supervariants identification for breast cancer
Hu J, Li T, Wang S, Zhang H. Supervariants identification for breast cancer. Genetic Epidemiology 2020, 44: 934-947. PMID: 32808324, PMCID: PMC7924970, DOI: 10.1002/gepi.22350.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesCombination of allelesRare variantsNovel lociChromosome 2UK Biobank databaseChromosome 1Multiple lociAssociation studiesLociComplex diseasesGenesBiobank databaseAssociation methodGenomeVariantsTens of thousandsAllelesPolymorphismNovel resultsSignalsClassic conceptIdentification
2013
NCK2 Is Significantly Associated with Opiates Addiction in African‐Origin Men
Liu Z, Guo X, Jiang Y, Zhang H. NCK2 Is Significantly Associated with Opiates Addiction in African‐Origin Men. The Scientific World JOURNAL 2013, 2013: 748979. PMID: 23533358, PMCID: PMC3603435, DOI: 10.1155/2013/748979.Peer-Reviewed Original ResearchConceptsSingle nucleotide polymorphismsNCK2 geneGenome-wide significant associationGenome-wide significant levelWide association studyGene-based methodsNumerous genetic variantsGWAS discoveryChromosome 2Association studiesNck2Genetic variantsGenesNucleotide polymorphismsComplex diseasesFirst evidenceGenetic disordersDiscoverySignificant levelsPolymorphismVariantsSubstantial effort
2012
Genetic Association Test for Multiple Traits at Gene Level
Guo X, Liu Z, Wang X, Zhang H. Genetic Association Test for Multiple Traits at Gene Level. Genetic Epidemiology 2012, 37: 122-129. PMID: 23032486, PMCID: PMC3524409, DOI: 10.1002/gepi.21688.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesMultiple traitsGene levelSingle nucleotide polymorphismsGenetic association testsCommon genesAssociation studiesAssociation TestNucleotide polymorphismsTraitsStudy of AddictionComplex diseasesBiological mechanismsDisease of interestAssociation informationGenesGeneticsSuch studiesStrong evidencePolymorphismPrevious findingsLevels
2011
Propensity score‐based nonparametric test revealing genetic variants underlying bipolar disorder
Jiang Y, Zhang H. Propensity score‐based nonparametric test revealing genetic variants underlying bipolar disorder. Genetic Epidemiology 2011, 35: 125-132. PMID: 21254220, PMCID: PMC3077545, DOI: 10.1002/gepi.20558.Peer-Reviewed Original ResearchConceptsSingle nucleotide polymorphismsGenetic variantsWellcome Trust Case Control ConsortiumRPGRIP1L geneGenetic studiesAssociation analysisHaplotype blocksChromosome 16Nucleotide polymorphismsComplex diseasesGenesComplex disorderStrong signalUnreported regionsVariantsImportant roleStrong evidencePolymorphismBipolar disorderRegion
2007
Polymorphisms of one-carbon-metabolizing genes and risk of breast cancer in a population-based study
Xu X, Gammon M, Zhang H, Wetmur J, Rao M, Teitelbaum S, Britton J, Neugut A, Santella R, Chen J. Polymorphisms of one-carbon-metabolizing genes and risk of breast cancer in a population-based study. Carcinogenesis 2007, 28: 1504-1509. PMID: 17372271, DOI: 10.1093/carcin/bgm061.Peer-Reviewed Original ResearchConceptsOne-carbon metabolismRate-limiting enzymeThymidylate synthaseRate-limiting genesOne-carbon pathwayDNA methylationEpigenetic processesSame pathwayGenesMethylenetetrahydrofolate reductaseDNA synthesisEnzymePathwayCritical rolePolymorphismSame populationCancer etiologyPopulation-based Long Island Breast Cancer Study ProjectMetabolismFunctional polymorphismsRepeat alleleMethylationReductaseAllelesSynthase
2006
Detection of Genes for Ordinal Traits in Nuclear Families and a Unified Approach for Association Studies
Zhang H, Wang X, Ye Y. Detection of Genes for Ordinal Traits in Nuclear Families and a Unified Approach for Association Studies. Genetics 2006, 172: 693-699. PMID: 16219774, PMCID: PMC1456175, DOI: 10.1534/genetics.105.049122.Peer-Reviewed Original ResearchConceptsSingle nucleotide polymorphismsQuantitative traitsOrdinal traitsTraditional linkage studiesGenomewide association analysisAssociation of genesDetection of genesGametic disequilibriumLoci existAssociation studiesAssociation analysisGenesLinkage disequilibriumTraitsComplex diseasesLinkage studiesGrowth-associated protein 43Protein 43DisequilibriumPolymorphismFamilyMarkersNuclear families
2005
A genome-wide tree- and forest-based association analysis of comorbidity of alcoholism and smoking
Ye Y, Zhong X, Zhang H. A genome-wide tree- and forest-based association analysis of comorbidity of alcoholism and smoking. BMC Genomic Data 2005, 6: s135. PMID: 16451594, PMCID: PMC1866801, DOI: 10.1186/1471-2156-6-s1-s135.Peer-Reviewed Original ResearchConceptsAssociation analysisGenetic Analysis Workshop 14Single nucleotide polymorphism dataJoint association analysisNew genesSingle nucleotide polymorphismsGenetic mechanismsPolymorphism dataAssociation studiesDeterministic forestsGenetics of AlcoholismGenesTreesUseful candidateGeneticsForestPolymorphismFuture studiesStudy of alcoholism