2019
Optimal timing of antenatal corticosteroid administration and preterm neonatal and early childhood outcomes
Battarbee AN, Ros ST, Esplin MS, Biggio J, Bukowski R, Parry S, Zhang H, Huang H, Andrews W, Saade G, Sadovsky Y, Reddy UM, Varner MW, Manuck TA, Research E. Optimal timing of antenatal corticosteroid administration and preterm neonatal and early childhood outcomes. American Journal Of Obstetrics & Gynecology MFM 2019, 2: 100077. PMID: 32905377, PMCID: PMC7469940, DOI: 10.1016/j.ajogmf.2019.100077.Peer-Reviewed Original ResearchConceptsRespiratory distress syndromeAntenatal corticosteroid administrationEarly childhood morbidityAntenatal corticosteroidsSevere neonatal morbidityChildhood morbidityDistress syndromeNeonatal morbidityCorticosteroid administrationSteroid administrationPreterm neonatesOptimal timingComposite neonatal morbidityPreterm birth researchCourse of corticosteroidsMean gestational ageSpontaneous preterm birthSpontaneous preterm laborProspective multicenter studyLong-term outcomesMultivariable logistic regressionEarly childhood outcomesAntenatal magnesiumNeonatal outcomesPreterm laborCervicovaginal fluid proteomic analysis to identify potential biomarkers for preterm birth
Parry S, Leite R, Esplin MS, Bukowski R, Zhang H, Varner M, Andrews WW, Saade GR, Ilekis J, Reddy UM, Huang H, Sadovsky Y, Blair IA, Biggio J, Research E. Cervicovaginal fluid proteomic analysis to identify potential biomarkers for preterm birth. American Journal Of Obstetrics And Gynecology 2019, 222: 493.e1-493.e13. PMID: 31758918, PMCID: PMC7196033, DOI: 10.1016/j.ajog.2019.11.1252.Peer-Reviewed Original ResearchConceptsPreterm birth casesSpontaneous preterm birthCervicovaginal fluid samplesEnzyme-linked immunosorbentTerm delivery controlsPreterm birthStudy visitBirth casesFluid samplesPotential biomarkersSpontaneous preterm birth ratePrior spontaneous preterm birthEarly spontaneous preterm birthCervical length screeningThird study visitVaginal mucosal cellsPreterm birth rateHigh-risk cohortCase-control studyReliable screening testAvailable biological fluidIndependent study groupsNeonatal morbidityObstetrical historyAsymptomatic women
2015
Predictors of response to 17-alpha hydroxyprogesterone caproate for prevention of recurrent spontaneous preterm birth
Manuck TA, Esplin MS, Biggio J, Bukowski R, Parry S, Zhang H, Huang H, Varner MW, Andrews W, Saade G, Sadovsky Y, Reddy UM, Ilekis J, Research E. Predictors of response to 17-alpha hydroxyprogesterone caproate for prevention of recurrent spontaneous preterm birth. American Journal Of Obstetrics And Gynecology 2015, 214: 376.e1-376.e8. PMID: 26692181, PMCID: PMC4803498, DOI: 10.1016/j.ajog.2015.12.010.Peer-Reviewed Original ResearchConceptsSpontaneous preterm birthPrevious spontaneous preterm birthRecurrent spontaneous preterm birthDelivery gestational ageRecurrent preterm birthPreterm birthSimilar gestational ageGestational ageHydroxyprogesterone caproateSingleton spontaneous preterm birthEarly spontaneous preterm birthFirst-degree family historyPreterm birth preventionHigh-risk womenPlanned secondary analysisPredictors of responseChi-square testPenultimate pregnancyPregnancy characteristicsNeonatal morbidityPregnancy coursePreterm pregnanciesBirth preventionCurrent pregnancyRegression models
2011
Estimating rates of multiple gestation pregnancies: Sample size calculation from the assessment of multiple intrauterine gestations from ovarian stimulation (AMIGOS) trial
Diamond MP, Mitwally M, Casper R, Ager J, Legro RS, Brzyski R, Casson P, Eisenberg E, Zhang H, Network F. Estimating rates of multiple gestation pregnancies: Sample size calculation from the assessment of multiple intrauterine gestations from ovarian stimulation (AMIGOS) trial. Contemporary Clinical Trials 2011, 32: 902-908. PMID: 21787883, PMCID: PMC3708642, DOI: 10.1016/j.cct.2011.07.009.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAromatase InhibitorsClomipheneDose-Response Relationship, DrugDouble-Blind MethodFemaleFertility Agents, FemaleGonadotropinsHumansInfant, NewbornInfertilityLetrozoleMaleNitrilesOvulation InductionPregnancyPregnancy OutcomePregnancy, MultipleProspective StudiesTreatment OutcomeTriazolesYoung AdultConceptsMultiple Intrauterine GestationsMultiple gestation pregnanciesOvulation inductionUnexplained infertilityGestation pregnanciesIntrauterine gestationMultiple gestationsComparable pregnancy ratesMono-follicular developmentOvarian stimulation (AMIGOS) trialOvarian hyperstimulation syndromePregnancy success ratePublic health benefitsExpense of careHyperstimulation syndromeClomiphene citrateNeonatal morbidityPreterm laborFertility medicationsPreterm infantsIntrauterine inseminationStimulation trialsAromatase inhibitorsPregnancy rateGestation