2020
Live birth after a freeze-only strategy versus fresh embryo transfer in three randomized trials considering progesterone concentration
Yu Y, Zhao S, Li Y, Niu Y, Wei D, Zhang S, Chen ZJ, Zhang H, Legro RS. Live birth after a freeze-only strategy versus fresh embryo transfer in three randomized trials considering progesterone concentration. Reproductive BioMedicine Online 2020, 41: 395-401. PMID: 32600942, DOI: 10.1016/j.rbmo.2020.04.021.Peer-Reviewed Original ResearchConceptsLive birth rateFresh embryo transferProgesterone concentrationsEmbryo transferOvulatory womenRandomized trialsBirth rateHuman chorionic gonadotrophin (HCG) administrationFresh embryo transfer groupCleavage-stage embryo transferFreeze-only strategyHigh ovarian responseInitial embryo transferPolycystic ovary syndromeChorionic gonadotrophin administrationEmbryo transfer groupFrozen embryo transferSingle blastocyst transferBetween-group differencesClinical pregnancyGonadotrophin administrationHCG administrationOvarian responseOvary syndromePrimary outcome
2018
Transfer of Fresh versus Frozen Embryos in Ovulatory Women
Shi Y, Sun Y, Hao C, Zhang H, Wei D, Zhang Y, Zhu Y, Deng X, Qi X, Li H, Ma X, Ren H, Wang Y, Zhang D, Wang B, Liu F, Wu Q, Wang Z, Bai H, Li Y, Zhou Y, Sun M, Liu H, Li J, Zhang L, Chen X, Zhang S, Sun X, Legro R, Chen Z. Transfer of Fresh versus Frozen Embryos in Ovulatory Women. New England Journal Of Medicine 2018, 378: 126-136. PMID: 29320646, DOI: 10.1056/nejmoa1705334.Peer-Reviewed Original ResearchConceptsFresh embryo transferFrozen embryo transferLive birth rateOvarian hyperstimulation syndromeHyperstimulation syndromeElective frozen embryo transferOvulatory womenFrozen-embryo groupFresh embryo groupIn vitro fertilization cyclesHigher live birth ratesPolycystic ovary syndromeRate of implantsCleavage-stage embryosOverall pregnancy lossAnovulatory womenNeonatal complicationsClinical pregnancyOngoing pregnancyFrozen embryosEmbryo cryopreservationBetween-group differencesEmbryo transferLive birthsFertilization cycles
2016
Fresh versus Frozen Embryos for Infertility in the Polycystic Ovary Syndrome
Chen ZJ, Shi Y, Sun Y, Zhang B, Liang X, Cao Y, Yang J, Liu J, Wei D, Weng N, Tian L, Hao C, Yang D, Zhou F, Shi J, Xu Y, Li J, Yan J, Qin Y, Zhao H, Zhang H, Legro RS. Fresh versus Frozen Embryos for Infertility in the Polycystic Ovary Syndrome. New England Journal Of Medicine 2016, 375: 523-533. PMID: 27509101, DOI: 10.1056/nejmoa1513873.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeOvarian hyperstimulation syndromeFresh embryo transferFrozen embryo transferFrozen-embryo transferOvary syndromeHyperstimulation syndromeLive birthsInfertile womenRate ratioFrozen embryosSignificant between-group differencesFresh embryo groupFirst IVF cycleLive birth rateFirst embryo transferBetween-group differencesNeonatal complicationsIVF cyclesPregnancy complicationsMulticenter trialPrimary outcomeNeonatal deathPregnancy lossHigh risk
2014
Letrozole versus Clomiphene for Infertility in the Polycystic Ovary Syndrome
Legro RS, Brzyski RG, Diamond MP, Coutifaris C, Schlaff WD, Casson P, Christman GM, Huang H, Yan Q, Alvero R, Haisenleder DJ, Barnhart KT, Bates GW, Usadi R, Lucidi S, Baker V, Trussell JC, Krawetz SA, Snyder P, Ohl D, Santoro N, Eisenberg E, Zhang H. Letrozole versus Clomiphene for Infertility in the Polycystic Ovary Syndrome. New England Journal Of Medicine 2014, 371: 119-129. PMID: 25006718, PMCID: PMC4175743, DOI: 10.1056/nejmoa1313517.Peer-Reviewed Original ResearchConceptsPolycystic ovary syndromeOvary syndromeCongenital anomaliesLive birthsHigh incidenceOvulation rateSignificant between-group differencesCumulative ovulation rateNormal uterine cavityOverall congenital anomaliesBetter pregnancy outcomesPatent fallopian tubesCumulative live birthMajor congenital anomaliesBetween-group differencesYears of ageClomiphene groupLetrozole groupRotterdam criteriaAdverse eventsHot flushesPregnancy outcomesInfertile womenMulticenter trialPrimary outcome