2014
Genes–Environment Interactions in Obesity- and Diabetes-Associated Pancreatic Cancer: A GWAS Data Analysis
Tang H, Wei P, Duell EJ, Risch HA, Olson SH, Bueno-de-Mesquita HB, Gallinger S, Holly EA, Petersen GM, Bracci PM, McWilliams RR, Jenab M, Riboli E, Tjønneland A, Boutron-Ruault MC, Kaaks R, Trichopoulos D, Panico S, Sund M, Peeters PH, Khaw KT, Amos CI, Li D. Genes–Environment Interactions in Obesity- and Diabetes-Associated Pancreatic Cancer: A GWAS Data Analysis. Cancer Epidemiology Biomarkers & Prevention 2014, 23: 98-106. PMID: 24136929, PMCID: PMC3947145, DOI: 10.1158/1055-9965.epi-13-0437-t.Peer-Reviewed Original ResearchConceptsPancreatic cancerIngenuity Pathway AnalysisSingle nucleotide polymorphismsAssociation of obesityPancreatic Cancer Case-Control ConsortiumRisk of obesityAlterable risk factorsPancreatic cancer riskRisk factor dataLogistic regression modelsGenome-wide levelAdditional large datasetsMajor contributing genesInsulin resistanceRisk factorsInflammatory responseCancer riskGene-environment interactionsObesityGene-environment interaction analysisSignificant interactionDiabetesGWAS data analysisCancerGenetic susceptibility
2013
An Absolute Risk Model to Identify Individuals at Elevated Risk for Pancreatic Cancer in the General Population
Klein AP, Lindström S, Mendelsohn JB, Steplowski E, Arslan AA, Bueno-de-Mesquita HB, Fuchs CS, Gallinger S, Gross M, Helzlsouer K, Holly EA, Jacobs EJ, LaCroix A, Li D, Mandelson MT, Olson SH, Petersen GM, Risch HA, Stolzenberg-Solomon RZ, Zheng W, Amundadottir L, Albanes D, Allen NE, Bamlet WR, Boutron-Ruault MC, Buring JE, Bracci PM, Canzian F, Clipp S, Cotterchio M, Duell EJ, Elena J, Gaziano JM, Giovannucci EL, Goggins M, Hallmans G, Hassan M, Hutchinson A, Hunter DJ, Kooperberg C, Kurtz RC, Liu S, Overvad K, Palli D, Patel AV, Rabe KG, Shu XO, Slimani N, Tobias GS, Trichopoulos D, Van Den Eeden SK, Vineis P, Virtamo J, Wactawski-Wende J, Wolpin BM, Yu H, Yu K, Zeleniuch-Jacquotte A, Chanock SJ, Hoover RN, Hartge P, Kraft P. An Absolute Risk Model to Identify Individuals at Elevated Risk for Pancreatic Cancer in the General Population. PLOS ONE 2013, 8: e72311. PMID: 24058443, PMCID: PMC3772857, DOI: 10.1371/journal.pone.0072311.Peer-Reviewed Original ResearchConceptsPancreatic cancerRisk factorsAbsolute risk modelsAbsolute riskElevated riskGeneral populationLifetime absolute riskGenetic factorsPopulation incidence ratesGenetic risk factorsNon-Hispanic whitesHeavy alcohol useImmediate clinical utilityRisk modelCurrent smokingIncidence rateRelative riskFamily historyModifiable behaviorsClinical utilityU.S. non-Hispanic whitesCancerAverage riskAlcohol useNon-genetic factors
2012
Pancreatitis and pancreatic cancer risk: a pooled analysis in the International Pancreatic Cancer Case-Control Consortium (PanC4)
Duell EJ, Lucenteforte E, Olson SH, Bracci PM, Li D, Risch HA, Silverman DT, Ji BT, Gallinger S, Holly EA, Fontham EH, Maisonneuve P, Bueno-de-Mesquita HB, Ghadirian P, Kurtz RC, Ludwig E, Yu H, Lowenfels AB, Seminara D, Petersen GM, La Vecchia C, Boffetta P. Pancreatitis and pancreatic cancer risk: a pooled analysis in the International Pancreatic Cancer Case-Control Consortium (PanC4). Annals Of Oncology 2012, 23: 2964-2970. PMID: 22767586, PMCID: PMC3477881, DOI: 10.1093/annonc/mds140.Peer-Reviewed Original ResearchConceptsInternational Pancreatic Cancer Case-Control ConsortiumPancreatic Cancer Case-Control ConsortiumPancreatic cancerOdds ratioStrong associationHistory of pancreatitisPopulation attributable fractionCase-control studyConfidence intervalsPancreatic cancer riskPooled odds ratioPancreatic cancer casesPrevious pancreatitisDuct obstructionPancreas cancerPooled analysisRisk factorsAttributable fractionCancer casesCancer riskPancreatitisCancerOld casesReverse causationDiagnosis
2003
Etiology of Pancreatic Cancer, With a Hypothesis Concerning the Role of N-Nitroso Compounds and Excess Gastric Acidity
Risch HA. Etiology of Pancreatic Cancer, With a Hypothesis Concerning the Role of N-Nitroso Compounds and Excess Gastric Acidity. Journal Of The National Cancer Institute 2003, 95: 948-960. PMID: 12837831, DOI: 10.1093/jnci/95.13.948.Peer-Reviewed Original ResearchConceptsPancreatic cancerGastric acidityRisk of nonsmokersConsumption of fruitsCurrent smokersDiabetes mellitusChronic pancreatitisCigarette smokingColorectal cancerCytokine mechanismsCancer deathDietary factorsDuodenal acidityRisk factorsEpidemiologic reviewFrequent causeHigh riskLower riskN-nitroso compoundsHelicobacter pyloriCancerGermline mutationsHost genetic variationRiskAnimal foods
1988
DIETARY FACTORS AND THE INCIDENCE OF CANCER OF THE URINARY BLADDER
RISCH H, BURCH J, MILLER A, HILL G, STEELE R, HOWE G. DIETARY FACTORS AND THE INCIDENCE OF CANCER OF THE URINARY BLADDER. American Journal Of Epidemiology 1988, 127: 1179-1191. PMID: 3369417, DOI: 10.1093/oxfordjournals.aje.a114911.Peer-Reviewed Original ResearchConceptsBladder cancerDietary factorsLow-calorie foodsConditional logistic regression methodsCalorie foodsIntake of cholesterolCase-control studyAge 20 yearsLife-style factorsIncidence of cancerHistory of exposureLack of associationOdds ratio estimatesArtificial sweetenersArea of residenceAverage daily intakeDiabetes mellitusCigarette smokingSubsequent riskCancer casesUrinary bladderRelevant food itemsMild increaseCancerDaily intake