2019
Mendelian randomisation study of height and body mass index as modifiers of ovarian cancer risk in 22,588 BRCA1 and BRCA2 mutation carriers
Qian F, Rookus MA, Leslie G, Risch HA, Greene MH, Aalfs CM, Adank MA, Adlard J, Agnarsson BA, Ahmed M, Aittomäki K, Andrulis IL, Arnold N, Arun BK, Ausems MGEM, Azzollini J, Barrowdale D, Barwell J, Benitez J, Białkowska K, Bonadona V, Borde J, Borg A, Bradbury AR, Brunet J, Buys SS, Caldés T, Caligo MA, Campbell I, Carter J, Chiquette J, Chung WK, Claes KBM, Collée JM, Collonge-Rame MA, Couch FJ, Daly MB, Delnatte C, Diez O, Domchek SM, Dorfling CM, Eason J, Easton DF, Eeles R, Engel C, Evans DG, Faivre L, Feliubadaló L, Foretova L, Friedman E, Frost D, Ganz PA, Garber J, Garcia-Barberan V, Gehrig A, Glendon G, Godwin AK, Gómez Garcia EB, Hamann U, Hauke J, Hopper JL, Hulick PJ, Imyanitov EN, Isaacs C, Izatt L, Jakubowska A, Janavicius R, John EM, Karlan BY, Kets CM, Laitman Y, Lázaro C, Leroux D, Lester J, Lesueur F, Loud JT, Lubiński J, Łukomska A, McGuffog L, Mebirouk N, Meijers-Heijboer HEJ, Meindl A, Miller A, Montagna M, Mooij TM, Mouret-Fourme E, Nathanson KL, Nehoray B, Neuhausen SL, Nevanlinna H, Nielsen FC, Offit K, Olah E, Ong KR, Oosterwijk JC, Ottini L, Parsons MT, Peterlongo P, Pfeiler G, Pradhan N, Radice P, Ramus SJ, Rantala J, Rennert G, Robson M, Rodriguez GC, Salani R, Scheuner MT, Schmutzler RK, Shah PD, Side LE, Simard J, Singer CF, Steinemann D, Stoppa-Lyonnet D, Tan YY, Teixeira MR, Terry MB, Thomassen M, Tischkowitz M, Tognazzo S, Toland AE, Tung N, van Asperen CJ, van Engelen K, van Rensburg EJ, Venat-Bouvet L, Vierstraete J, Wagner G, Walker L, Weitzel JN, Yannoukakos D, Antoniou A, Goldgar D, Olopade O, Chenevix-Trench G, Rebbeck T, Huo D. Mendelian randomisation study of height and body mass index as modifiers of ovarian cancer risk in 22,588 BRCA1 and BRCA2 mutation carriers. British Journal Of Cancer 2019, 121: 180-192. PMID: 31213659, PMCID: PMC6738050, DOI: 10.1038/s41416-019-0492-8.Peer-Reviewed Original ResearchConceptsBody mass indexOvarian cancer riskBRCA1/2 mutation carriersBRCA2 mutation carriersCancer riskMutation carriersMass indexGeneral populationHigher ovarian cancer riskHigher body mass indexGenetic scoreOvarian cancer casesMendelian randomisation studyMendelian randomisation approachConsortium of InvestigatorsPostmenopausal womenPremenopausal womenMenopausal statusCancer casesCox modelConclusionOur observationsRandomisation approachM2 increaseRiskPositive association
2017
A pooled analysis of dietary sugar/carbohydrate intake and esophageal and gastric cardia adenocarcinoma incidence and survival in the USA
Li N, Petrick JL, Steck SE, Bradshaw PT, McClain KM, Niehoff NM, Engel LS, Shaheen NJ, Risch HA, Vaughan TL, Wu AH, Gammon MD. A pooled analysis of dietary sugar/carbohydrate intake and esophageal and gastric cardia adenocarcinoma incidence and survival in the USA. International Journal Of Epidemiology 2017, 46: 1836-1846. PMID: 29040685, PMCID: PMC5837717, DOI: 10.1093/ije/dyx203.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAgedBlood GlucoseBody Mass IndexCase-Control StudiesDietary CarbohydratesDietary SucroseEsophageal NeoplasmsFemaleGastroesophageal RefluxHumansIncidenceLogistic ModelsMaleMiddle AgedMultivariate AnalysisNutrition AssessmentProportional Hazards ModelsRisk FactorsStomach NeoplasmsUnited StatesConceptsGastro-esophageal reflux diseaseBody mass indexCarbohydrate intakeAdenocarcinoma incidenceGCA incidenceOdds ratioUS population-based case-control studyStudy-specific food-frequency questionnairesPopulation-based case-control studyCox proportional hazards regressionGlycaemic indexDietary glycaemic indexFood frequency questionnaireProportional hazards regressionCase-control studyIntake of sucroseHigh glycaemic indexCarbohydrate measuresFrequency questionnaireHazard ratioReflux diseaseMass indexHazards regressionVital statusPooled analysis
2016
Adult body mass index and risk of ovarian cancer by subtype: a Mendelian randomization study
Dixon SC, Nagle CM, Thrift AP, Pharoah PD, Pearce CL, Zheng W, Painter JN, Study A, Chenevix-Trench G, Fasching P, Beckmann M, Lambrechts D, Vergote I, Lambrechts S, Van Nieuwenhuysen E, Rossing M, Doherty J, Wicklund K, Chang-Claude J, Rudolph A, Moysich K, Odunsi K, Goodman M, Wilkens L, Thompson P, Shvetsov Y, Dörk T, Park-Simon T, Hillemanns P, Bogdanova N, Butzow R, Nevanlinna H, Pelttari L, Leminen A, Modugno F, Ness R, Edwards R, Kelley J, Heitz F, Karlan B, Kjær S, Høgdall E, Jensen A, Goode E, Fridley B, Cunningham J, Winham S, Giles G, Bruinsma F, Milne R, Southey M, Hildebrandt M, Wu X, Lu K, Liang D, Levine D, Bisogna M, Schildkraut J, Berchuck A, Cramer D, Terry K, Bandera E, Olson S, Salvesen H, Thomsen L, Kopperud R, Bjorge L, Kiemeney L, Massuger L, Pejovic T, Cook L, Le N, Swenerton K, Brooks-Wilson A, Kelemen L, Lubiński J, Huzarski T, Gronwald J, Menkiszak J, Wentzensen N, Brinton L, Yang H, Lissowska J, Høgdall C, Lundvall L, Song H, Tyrer J, Campbell I, Eccles D, Paul J, Glasspool R, Siddiqui N, Whittemore A, Sieh W, McGuire V, Rothstein J, Narod S, Phelan C, Risch H, McLaughlin J, Anton-Culver H, Ziogas A, Menon U, Gayther S, Ramus S, Gentry-Maharaj A, Wu A, Pike M, Tseng C, Kupryjanczyk J, Dansonka-Mieszkowska A, Budzilowska A, Spiewankiewicz B, Webb P, Consortium O. Adult body mass index and risk of ovarian cancer by subtype: a Mendelian randomization study. International Journal Of Epidemiology 2016, 45: 884-895. PMID: 27401727, PMCID: PMC5644573, DOI: 10.1093/ije/dyw158.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAllelesBody Mass IndexFemaleGenetic MarkersGenome-Wide Association StudyGenotypeHumansLogistic ModelsMendelian Randomization AnalysisMeta-Analysis as TopicMiddle AgedMultivariate AnalysisObesityOvarian NeoplasmsPolymorphism, Single NucleotideRisk FactorsYoung AdultConceptsBody mass indexOvarian cancerSerous cancerMass indexOdds ratioObservational studyMendelian randomizationStudy-specific odds ratiosHigher body mass indexAdult body mass indexGrade serous ovarian cancerConfidence intervalsOvarian cancer riskOvarian Cancer Association ConsortiumSerous ovarian cancerWeighted genetic risk scoreLack of associationMendelian randomization studyGenetic risk scoreStrength of associationHistological subtypesRisk factorsCancer riskRisk scoreHGSC subtype
2015
Body Mass Index Genetic Risk Score and Endometrial Cancer Risk
Prescott J, Setiawan VW, Wentzensen N, Schumacher F, Yu H, Delahanty R, Bernstein L, Chanock SJ, Chen C, Cook LS, Friedenreich C, Garcia-Closas M, Haiman CA, Le Marchand L, Liang X, Lissowska J, Lu L, Magliocco AM, Olson SH, Risch HA, Shu XO, Ursin G, Yang HP, Kraft P, De Vivo I. Body Mass Index Genetic Risk Score and Endometrial Cancer Risk. PLOS ONE 2015, 10: e0143256. PMID: 26606540, PMCID: PMC4659592, DOI: 10.1371/journal.pone.0143256.Peer-Reviewed Original ResearchConceptsEndometrial cancer riskBody mass indexGenotype risk scoreCancer riskRisk scoreHigher body mass indexRisk allelesIndependent risk factorEndometrial cancer casesExcess body weightRisk factor dataGenetic risk scoreGenome-wide association studiesEndometrial cancerMass indexBMI riskRisk factorsEffect modificationCancer casesRisk lociBody weightCancer shareExploratory analysisStudy designControl participantsObesity and survival among women with ovarian cancer: results from the Ovarian Cancer Association Consortium
Nagle CM, Dixon SC, Jensen A, Kjaer SK, Modugno F, deFazio A, Fereday S, Hung J, Johnatty SE, Fasching P, Beckmann M, Lambrechts D, Vergote I, Van Nieuwenhuysen E, Lambrechts S, Risch H, Rossing M, Doherty J, Wicklund K, Chang-Claude J, Goodman M, Ness R, Moysich K, Heitz F, du Bois A, Harter P, Schwaab I, Matsuo K, Hosono S, Goode E, Vierkant R, Larson M, Fridley B, Høgdall C, Schildkraut J, Weber R, Cramer D, Terry K, Bandera E, Paddock L, Rodriguez-Rodriguez L, Wentzensen N, Yang H, Brinton L, Lissowska J, Høgdall E, Lundvall L, Whittemore A, McGuire V, Sieh W, Rothstein J, Sutphen R, Anton-Culver H, Ziogas A, Pearce C, Wu A, Webb P. Obesity and survival among women with ovarian cancer: results from the Ovarian Cancer Association Consortium. British Journal Of Cancer 2015, 113: 817-826. PMID: 26151456, PMCID: PMC4559823, DOI: 10.1038/bjc.2015.245.Peer-Reviewed Original ResearchConceptsProgression-free survivalBody mass indexOvarian cancer-specific survivalCancer-specific survivalOvarian cancerHazard ratioHistologic subtypeOverall survivalHigh-grade serous cancerHigher Body Mass IndexInvasive ovarian cancerPooled hazard ratioDifferent histologic subtypesOvarian Cancer Association ConsortiumMajority of womenRandom-effects modelAdverse survivalPooled HRsSerous cancerEndometrioid subtypeMass indexOvarian carcinomaObservational studyModest associationCancerDietary flavonoid intake and Barrett's esophagus in western Washington State
Petrick JL, Steck SE, Bradshaw PT, Chow WH, Engel LS, He K, Risch HA, Vaughan TL, Gammon MD. Dietary flavonoid intake and Barrett's esophagus in western Washington State. Annals Of Epidemiology 2015, 25: 730-735.e2. PMID: 26169148, PMCID: PMC4567908, DOI: 10.1016/j.annepidem.2015.05.010.Peer-Reviewed Original ResearchConceptsOdds of BESpecialized intestinal metaplasiaBarrett's esophagusOdds ratioIntestinal metaplasiaInverse associationPrecursor lesionsWestern Washington StateDietary flavonoid intakeDecreased odds ratioFood frequency questionnaireAdequate dietary intakeBody mass indexCase-control investigationCancer precursor lesionsCase-control study participantsDietary sourcesLogistic regression modelsFlavonoid classesMain dietary sourceAnthocyanidin intakeFrequency questionnaireFlavonoid intakeMass indexIsoflavone intake
2014
Obesity and Risk of Esophageal Adenocarcinoma and Barrett’s Esophagus: A Mendelian Randomization Study
Thrift AP, Shaheen NJ, Gammon MD, Bernstein L, Reid BJ, Onstad L, Risch HA, Liu G, Bird NC, Wu AH, Corley DA, Romero Y, Chanock SJ, Chow WH, Casson AG, Levine DM, Zhang R, Ek WE, MacGregor S, Ye W, Hardie LJ, Vaughan TL, Whiteman DC. Obesity and Risk of Esophageal Adenocarcinoma and Barrett’s Esophagus: A Mendelian Randomization Study. Journal Of The National Cancer Institute 2014, 106: dju252. PMID: 25269698, PMCID: PMC4200028, DOI: 10.1093/jnci/dju252.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAgedBarrett EsophagusBody Mass IndexEsophageal NeoplasmsFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMendelian Randomization AnalysisMiddle AgedObesityPolymorphism, Single NucleotidePrecancerous ConditionsPredictive Value of TestsRisk AssessmentRisk FactorsConceptsBody mass indexBarrett's esophagusEsophageal adenocarcinomaGenetic risk scoreConventional epidemiologic analysisRisk scoreEpidemiologic analysisRisk of EACLifetime body mass indexInstrumental variable analysisGastroesophageal reflux symptomsMendelian randomization studyMendelian randomization approachGenetic susceptibility studiesGenetic propensityReflux symptomsMass indexEAC riskPotential confoundersEsophageal metaplasiaObservational studyHigh riskObesityUnconfounded effectRandomization studyGastroesophageal Reflux in Relation to Adenocarcinomas of the Esophagus: A Pooled Analysis from the Barrett’s and Esophageal Adenocarcinoma Consortium (BEACON)
Cook MB, Corley DA, Murray LJ, Liao LM, Kamangar F, Ye W, Gammon MD, Risch HA, Casson AG, Freedman ND, Chow WH, Wu AH, Bernstein L, Nyrén O, Pandeya N, Whiteman DC, Vaughan TL. Gastroesophageal Reflux in Relation to Adenocarcinomas of the Esophagus: A Pooled Analysis from the Barrett’s and Esophageal Adenocarcinoma Consortium (BEACON). PLOS ONE 2014, 9: e103508. PMID: 25075959, PMCID: PMC4116205, DOI: 10.1371/journal.pone.0103508.Peer-Reviewed Original ResearchConceptsEsophagogastric junction adenocarcinomaBody mass indexRegurgitation symptomsEsophageal adenocarcinomaEsophageal Adenocarcinoma ConsortiumGastroesophageal refluxCigarette smokingMass indexMultivariable logistic regressionFrequency of symptomsMajor risk factorCase-control studyHeartburn durationSymptom durationJunction adenocarcinomaPooled analysisRisk factorsCancer sitesOdds ratioStratified analysisHigh riskSummary estimatesSignificant associationSymptomsLogistic regression
2013
The Healthy Eating Index 2005 and Risk for Pancreatic Cancer in the NIH–AARP Study
Arem H, Reedy J, Sampson J, Jiao L, Hollenbeck AR, Risch H, Mayne ST, Stolzenberg-Solomon RZ. The Healthy Eating Index 2005 and Risk for Pancreatic Cancer in the NIH–AARP Study. Journal Of The National Cancer Institute 2013, 105: 1298-1305. PMID: 23949329, PMCID: PMC3760780, DOI: 10.1093/jnci/djt185.Peer-Reviewed Original ResearchConceptsHealthy Eating Index 2005Pancreatic cancer riskPancreatic cancerHazard ratioDietary guidelinesCancer riskExocrine pancreatic cancer casesOverweight/obese menCox proportional hazards regressionHealth-American AssociationP-interaction valuesRetired Persons DietFood frequency questionnaireNormal-weight menDietary pattern analysisBody mass indexProportional hazards regressionConfidence intervalsPancreatic cancer casesNIH-AARP studyFrequency questionnaireObese menMass indexHazards regressionWeight menDietary fat intake and risk of pancreatic cancer in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial
Arem H, Mayne ST, Sampson J, Risch H, Stolzenberg-Solomon RZ. Dietary fat intake and risk of pancreatic cancer in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. Annals Of Epidemiology 2013, 23: 571-575. PMID: 23890797, PMCID: PMC3752990, DOI: 10.1016/j.annepidem.2013.06.006.Peer-Reviewed Original ResearchConceptsDietary fat intakePancreatic cancer riskOvarian Cancer Screening TrialCancer Screening TrialFat intakeCancer riskInverse associationPancreatic cancerScreening TrialCox proportional hazards regressionTotal fat intakeProportional hazards regressionObserved inverse associationPancreatic cancer casesHazards regressionCancer casesRisk associationUndetected diseasePossible reverse causationDietary changesIntakeReverse causationColorectalFat typeRiskObesity and risk of ovarian cancer subtypes: evidence from the Ovarian Cancer Association Consortium
Olsen CM, Nagle CM, Whiteman DC, Ness R, Pearce CL, Pike MC, Rossing MA, Terry KL, Wu AH, _ _, _ _, Risch HA, Yu H, Doherty JA, Chang-Claude J, Hein R, Nickels S, Wang-Gohrke S, Goodman MT, Carney ME, Matsuno RK, Lurie G, Moysich K, Kjaer SK, Jensen A, Hogdall E, Goode EL, Fridley BL, Vierkant RA, Larson MC, Schildkraut J, Hoyo C, Moorman P, Weber RP, Cramer DW, Vitonis AF, Bandera EV, Olson SH, Rodriguez-Rodriguez L, King M, Brinton LA, Yang H, Garcia-Closas M, Lissowska J, Anton-Culver H, Ziogas A, Gayther SA, Ramus SJ, Menon U, Gentry-Maharaj A, Webb PM. Obesity and risk of ovarian cancer subtypes: evidence from the Ovarian Cancer Association Consortium. Endocrine Related Cancer 2013, 20: 251-262. PMID: 23404857, PMCID: PMC3857135, DOI: 10.1530/erc-12-0395.Peer-Reviewed Original ResearchMeSH KeywordsBody Mass IndexFemaleHumansNeoplasm GradingObesityOdds RatioOvarian NeoplasmsRiskSocieties, MedicalConceptsOvarian Cancer Association ConsortiumHistological subtypesHigher BMIOdds ratioOvarian cancerHormone replacement therapy usersPost-menopausal hormone useInvasive serous cancerCommon histological subtypeOvarian cancer deathsPre-menopausal womenPrevalence of obesityPost-menopausal womenDifferent histological subtypesOvarian cancer riskCase-control studyOvarian cancer subtypesRandom-effects modelMenopausal statusSerous cancerHormone useTherapy usersInvasive cancerModifiable factorsPooled analysis
2012
Body mass index in relation to oesophageal and oesophagogastric junction adenocarcinomas: a pooled analysis from the International BEACON Consortium
Hoyo C, Cook MB, Kamangar F, Freedman ND, Whiteman DC, Bernstein L, Brown LM, Risch HA, Ye W, Sharp L, Wu AH, Ward MH, Casson AG, Murray LJ, Corley DA, Nyrén O, Pandeya N, Vaughan TL, Chow WH, Gammon MD. Body mass index in relation to oesophageal and oesophagogastric junction adenocarcinomas: a pooled analysis from the International BEACON Consortium. International Journal Of Epidemiology 2012, 41: 1706-1718. PMID: 23148106, PMCID: PMC3535758, DOI: 10.1093/ije/dys176.Peer-Reviewed Original ResearchConceptsOesophagogastric junction adenocarcinomaBody mass indexGERD symptomsOdds ratioMass indexGastro-oesophageal reflux symptomsStudy-specific odds ratiosInternational BEACON ConsortiumRisk of oesophagealEffect of obesityConfidence intervalsIndividual participant dataReflux symptomsJunction adenocarcinomaOesophagogastric junctionPooled analysisControl subjectsOA casesEffect modificationBMIEpidemiological studiesOesophagealSymptomsPreventive effortsLogistic regressionHeight, weight, BMI and ovarian cancer survival
Kotsopoulos J, Moody JR, Fan I, Rosen B, Risch HA, McLaughlin JR, Sun P, Narod SA. Height, weight, BMI and ovarian cancer survival. Gynecologic Oncology 2012, 127: 83-87. PMID: 22713293, DOI: 10.1016/j.ygyno.2012.05.038.Peer-Reviewed Original ResearchConceptsBody mass indexOvarian cancer survivalOvarian cancer-specific mortalityCancer-specific mortalityHazard ratioCancer survivalOvarian cancerLarge population-based studyBMI 5 yearsFatal gynecologic malignancyPopulation-based studyEpithelial ovarian cancerConfidence intervalsOvarian cancer prognosisProportional hazards modelChart reviewGynecologic malignanciesClinicopathologic featuresHistologic subtypeMass indexVital statusModifiable factorsRisk factorsHazards modelCancer prognosisThe importance of exposure rate on odds ratios by cigarette smoking and alcohol consumption for esophageal adenocarcinoma and squamous cell carcinoma in the Barrett's Esophagus and Esophageal Adenocarcinoma Consortium
Lubin JH, Cook MB, Pandeya N, Vaughan TL, Abnet CC, Giffen C, Webb PM, Murray LJ, Casson AG, Risch HA, Ye W, Kamangar F, Bernstein L, Sharp L, Nyrén O, Gammon MD, Corley DA, Wu AH, Brown LM, Chow WH, Ward MH, Freedman ND, Whiteman DC. The importance of exposure rate on odds ratios by cigarette smoking and alcohol consumption for esophageal adenocarcinoma and squamous cell carcinoma in the Barrett's Esophagus and Esophageal Adenocarcinoma Consortium. Cancer Epidemiology 2012, 36: 306-316. PMID: 22504051, PMCID: PMC3489030, DOI: 10.1016/j.canep.2012.03.001.Peer-Reviewed Original ResearchConceptsEsophagogastric junctional adenocarcinomaBody mass indexSquamous cell carcinomaEsophageal adenocarcinomaEsophageal Adenocarcinoma ConsortiumCigarette smokingAlcohol consumptionAcid refluxCell carcinomaBarrett's esophagusInverse associationEffect modificationYounger ageCigarettes/dayDrinks/dayExposure rateSignificant effect modificationCase-control studyTotal exposureHigh exposure rateEvaluated effect modificationJunctional adenocarcinomaMass indexSmoking effectsOdds ratio
2011
Long‐term overweight and weight gain in early adulthood in association with risk of endometrial cancer
Lu L, Risch H, Irwin ML, Mayne ST, Cartmel B, Schwartz P, Rutherford T, Yu H. Long‐term overweight and weight gain in early adulthood in association with risk of endometrial cancer. International Journal Of Cancer 2011, 129: 1237-1243. PMID: 21387312, PMCID: PMC3125463, DOI: 10.1002/ijc.26046.Peer-Reviewed Original ResearchConceptsBody mass indexLong-term overweightEndometrial cancerSubstantial weight gainWeight gainBody weightPopulation-based case-control studyHigher body mass indexEndometrial cancer riskWeight changeDisease 10 yearsEarly adulthoodUnconditional logistic regressionAdult lifeCase-control studyTime of interviewSuch weight changesMass indexNormal weightIncident casesRisk factorsOdds ratioLong-term effectsAge 40Cancer riskPrincipal Component Analysis of Dietary and Lifestyle Patterns in Relation to Risk of Subtypes of Esophageal and Gastric Cancer
Silvera S, Mayne ST, Risch HA, Gammon MD, Vaughan T, Chow WH, Dubin JA, Dubrow R, Schoenberg J, Stanford JL, West AB, Rotterdam H, Blot WJ. Principal Component Analysis of Dietary and Lifestyle Patterns in Relation to Risk of Subtypes of Esophageal and Gastric Cancer. Annals Of Epidemiology 2011, 21: 543-550. PMID: 21435900, PMCID: PMC3109225, DOI: 10.1016/j.annepidem.2010.11.019.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAgedBody Mass IndexCase-Control StudiesConnecticutDietEsophageal NeoplasmsFemaleGastroesophageal RefluxHealth BehaviorHumansLife StyleLogistic ModelsMaleMiddle AgedNeoplasms, Squamous CellNew JerseyPrincipal Component AnalysisRegistriesRisk FactorsStomach NeoplasmsSurveys and QuestionnairesWashingtonConceptsEsophageal squamous cell carcinomaGastric cardia adenocarcinomaRisk of EACSmoking/alcoholGastroesophageal reflux diseaseEsophageal adenocarcinomaRisk factorsGastric cancerPopulation-based case-control studyRisk of ESCCFruit/vegetable intakeLifestyle patternsSquamous cell carcinomaRisk of subtypesCase-control studyFruits/vegetablesReflux diseaseLifestyle factorsVegetable scoresCell carcinomaVegetable intakeNitrite intakeAlcohol scoresCancer casesCancer risk
2010
Pre- and post-diagnosis body mass index, weight change, and ovarian cancer mortality
Zhou Y, Irwin ML, Risch HA. Pre- and post-diagnosis body mass index, weight change, and ovarian cancer mortality. Gynecologic Oncology 2010, 120: 209-213. PMID: 21106231, PMCID: PMC3034401, DOI: 10.1016/j.ygyno.2010.10.035.Peer-Reviewed Original ResearchConceptsOvarian cancer mortalityCancer mortalityTime pointsWeight changeHigh riskPost-diagnosis body mass indexOvarian cancer-specific mortalityBMI 5 yearsCancer-specific mortalityInterview-administered questionnaireProportional hazards regressionBody mass indexEpithelial ovarian cancerCause mortalityHazards regressionMass indexSpecific mortalityOvarian cancerBMISurvival rateMortalityWeight gainDiagnosisStrong associationWomen
2008
Cigarette smoking, body mass index, gastro-esophageal reflux disease, and non-steroidal anti-inflammatory drug use and risk of subtypes of esophageal and gastric cancers by P53 overexpression
Figueroa JD, Terry MB, Gammon MD, Vaughan TL, Risch HA, Zhang FF, Kleiner DE, Bennett WP, Howe CL, Dubrow R, Mayne ST, Fraumeni JF, Chow WH. Cigarette smoking, body mass index, gastro-esophageal reflux disease, and non-steroidal anti-inflammatory drug use and risk of subtypes of esophageal and gastric cancers by P53 overexpression. Cancer Causes & Control 2008, 20: 361-368. PMID: 18989634, PMCID: PMC2726999, DOI: 10.1007/s10552-008-9250-6.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAgedAnti-Inflammatory Agents, Non-SteroidalBody Mass IndexCarcinoma, Squamous CellCardiaCase-Control StudiesConfidence IntervalsEsophageal NeoplasmsGastroesophageal RefluxHumansImmunohistochemistryLogistic ModelsMiddle AgedMulticenter Studies as TopicOdds RatioPopulation SurveillanceRisk FactorsSmokingStomach NeoplasmsTumor Suppressor Protein p53United StatesConceptsBody mass indexNon-steroidal anti-inflammatory drugsGastroesophageal reflux diseaseRisk factorsP53 overexpressionGastric cancerCigarette smokingReflux diseaseMass indexNon-steroidal anti-inflammatory drug useTumor subtypesPopulation-based case-control studyAnti-inflammatory drug useNon-cardia gastric adenocarcinomaGastro-esophageal reflux diseaseLarger body mass indexNon-cardia gastric cancerEsophageal squamous cell carcinomaTumor p53 overexpressionRisk factor profileSquamous cell carcinomaRisk of subtypesCase-control studyAnti-inflammatory drugsP53 protein overexpression
2003
Population Attributable Risks of Esophageal and Gastric Cancers
Engel LS, Chow W, Vaughan TL, Gammon MD, Risch HA, Stanford JL, Schoenberg JB, Mayne ST, Dubrow R, Rotterdam H, West AB, Blaser M, Blot WJ, Gail MH, Fraumeni JF. Population Attributable Risks of Esophageal and Gastric Cancers. Journal Of The National Cancer Institute 2003, 95: 1404-1413. PMID: 13130116, DOI: 10.1093/jnci/djg047.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAgedAlcohol DrinkingBody Mass IndexCarcinoma, Squamous CellCardiaCase-Control StudiesConfounding Factors, EpidemiologicEnzyme-Linked Immunosorbent AssayEsophageal NeoplasmsFeeding BehaviorFemaleFruitGastroesophageal RefluxHumansLife StyleMaleMiddle AgedNitritesObesityRisk AssessmentRisk FactorsSmokingStomach NeoplasmsStomach UlcerUnited StatesVegetablesConceptsCombined population attributable riskPopulation attributable riskNoncardia gastric adenocarcinomaEsophageal squamous cell carcinomaSquamous cell carcinomaGastric cardia adenocarcinomaBody mass indexGastric adenocarcinomaRisk factorsCell carcinomaCardia adenocarcinomaGastroesophageal refluxMass indexPylori infectionAttributable riskEsophageal adenocarcinomaGastric cancerVegetable consumptionMulticenter population-based case-control studyPopulation-based case-control studyPrevalence of smokingH. pylori infectionHelicobacter pylori infectionCase-control studyLow fruit
1998
Body Mass Index and Risk of Adenocarcinomas of the Esophagus and Gastric Cardia
Chow W, Blot W, Vaughan T, Risch H, Gammon M, Stanford J, Dubrow R, Schoenberg J, Mayne S, Farrow D, Ahsan H, West A, Rotterdam H, Niwa S, Fraumeni J. Body Mass Index and Risk of Adenocarcinomas of the Esophagus and Gastric Cardia. Journal Of The National Cancer Institute 1998, 90: 150-155. PMID: 9450576, DOI: 10.1093/jnci/90.2.150.Peer-Reviewed Original ResearchConceptsBody mass indexEsophageal squamous cell carcinomaNoncardia gastric adenocarcinomaSquamous cell carcinomaGastric cardia adenocarcinomaAdult body mass indexOdds ratioCell carcinomaGastric adenocarcinomaCardia adenocarcinomaGastric cardiaCase patientsMass indexEsophageal adenocarcinomaPopulation-based case-control studyAge groupsRisk of adenocarcinomaAdenocarcinoma of esophagusAnthropometric risk factorsPrevalence of obesityHealthy control subjectsCase-control studyYounger age groupsMagnitude of associationUnited States population