Genome-wide association study of subtype-specific epithelial ovarian cancer risk alleles using pooled DNA
Earp MA, Kelemen LE, Magliocco AM, Swenerton KD, Chenevix-Trench G, Australian Cancer Study, Australian Ovarian Cancer Study Group, Lu Y, Hein A, Ekici AB, Beckmann MW, Fasching PA, Lambrechts D, Despierre E, Vergote I, Lambrechts S, Doherty JA, Rossing MA, Chang-Claude J, Rudolph A, Friel G, Moysich KB, Odunsi K, Sucheston-Campbell L, Lurie G, Goodman MT, Carney ME, Thompson PJ, Runnebaum IB, Dürst M, Hillemanns P, Dörk T, Antonenkova N, Bogdanova N, Leminen A, Nevanlinna H, Pelttari LM, Butzow R, Bunker CH, Modugno F, Edwards RP, Ness RB, du Bois A, Heitz F, Schwaab I, Harter P, Karlan BY, Walsh C, Lester J, Jensen A, Kjær SK, Høgdall CK, Høgdall E, Lundvall L, Sellers TA, Fridley BL, Goode EL, Cunningham JM, Vierkant RA, Giles GG, Baglietto L, Severi G, Southey MC, Liang D, Wu X, Lu K, Hildebrandt MA, Levine DA, Bisogna M, Schildkraut JM, Iversen ES, Weber RP, Berchuck A, Cramer DW, Terry KL, Poole EM, Tworoger SS, Bandera EV, Chandran U, Orlow I, Olson SH, Wik E, Salvesen HB, Bjorge L, Halle MK, van Altena AM, Aben KK, Kiemeney LA, Massuger LF, Pejovic T, Bean YT, Cybulski C, Gronwald J, Lubinski J, Wentzensen N, Brinton LA, Lissowska J, Garcia-Closas M, Dicks E, Dennis J, Easton DF, Song H, Tyrer JP, Pharoah PD, Eccles D, Campbell IG, Whittemore AS, McGuire V, Sieh W, Rothstein JH, Flanagan JM, Paul J, Brown R, Phelan CM, Risch HA, McLaughlin JR, Narod SA, Ziogas A, Anton-Culver H, Gentry-Maharaj A, Menon U, Gayther SA, Ramus SJ, Wu AH, Pearce CL, Pike MC, Dansonka-Mieszkowska A, Rzepecka IK, Szafron LM, Kupryjanczyk J, Cook LS, Le ND, Brooks-Wilson A, On behalf of the Ovarian Cancer Association Consortium. Genome-wide association study of subtype-specific epithelial ovarian cancer risk alleles using pooled DNA. Human Genetics 2013, 133: 481-497. PMID: 24190013, PMCID: PMC4063682, DOI: 10.1007/s00439-013-1383-3.Peer-Reviewed Original ResearchConceptsEpithelial ovarian cancerEOC riskAssociation studiesOdds ratioEOC subtypesGenome-wide association studiesMucinous epithelial ovarian cancerWide association studyClear cell epithelial ovarian cancerSerous epithelial ovarian cancerCancer risk allelesUnconditional logistic regressionLog-additive genetic modelEnvironmental risk factorsEuropean descentGWAS resultsPre-defined criteriaGenomic DNAGWAS samplesRisk factorsOvarian cancerCombined and Interactive Effects of Environmental and GWAS-Identified Risk Factors in Ovarian Cancer
Pearce CL, Rossing MA, Lee AW, Ness RB, Webb PM, Study F, Group A, Chenevix-Trench G, Jordan SM, Stram DA, Chang-Claude J, Hein R, Nickels S, Lurie G, Thompson PJ, Carney ME, Goodman MT, Moysich K, Hogdall E, Jensen A, Goode EL, Fridley BL, Cunningham JM, Vierkant RA, Weber RP, Ziogas A, Anton-Culver H, Gayther SA, Gentry-Maharaj A, Menon U, Ramus SJ, Brinton L, Wentzensen N, Lissowska J, Garcia-Closas M, Massuger LF, Kiemeney LA, Van Altena AM, Aben KK, Berchuck A, Doherty JA, Iversen E, McGuire V, Moorman PG, Pharoah P, Pike MC, Risch H, Sieh W, Stram DO, Terry KL, Whittemore A, Wu AH, Schildkraut JM, Kjaer SK, Consortium F. Combined and Interactive Effects of Environmental and GWAS-Identified Risk Factors in Ovarian Cancer. Cancer Epidemiology Biomarkers & Prevention 2013, 22: 880-890. PMID: 23462924, PMCID: PMC3963289, DOI: 10.1158/1055-9965.epi-12-1030-t.Peer-Reviewed Original ResearchConceptsEnvironmental risk factorsGenetic risk scoreOvarian cancer riskRisk factorsHistologic subtypeRisk scoreOvarian cancerCancer riskHigh genetic risk scoreOvarian cancer case-control studiesCancer case-control studyCase-control studySuch risk factorsGenetic risk factorsRecent genome-wide association studiesTubal ligationRisk differenceDisease riskSubtypesMultivariate modelCancerRisk prediction modelingRiskScoresEffects model