2022
The age-dependent association of risk factors with pancreatic cancer
Yuan C, Kim J, Wang QL, Lee AA, Babic A, Consortium P, Amundadottir LT, Ardanaz E, Arslan A, Beane-Freeman L, Bracci P, Bueno-de-Mesquita B, Du M, Gallinger S, Giles G, Goodman P, Katzke V, Klein A, Kooperberg C, Kraft P, Li D, Malats N, Marchand L, McCullough M, Milne R, Neoptolemos J, Perdomo S, Petersen G, Risch H, Shu X, Stolzenberg-Solomon R, Van Den Eeden S, Visvanathan K, White E, Wolpin B, Zheng W, Amundadottir L, Klein A, Li D, McCullough M, Petersen G, Risch H, Stolzenberg-Solomon R, Perez K, Ng K, Giovannucci E, Stampfer M, Kraft P, Wolpin B. The age-dependent association of risk factors with pancreatic cancer. Annals Of Oncology 2022, 33: 693-701. PMID: 35398288, PMCID: PMC9233063, DOI: 10.1016/j.annonc.2022.03.276.Peer-Reviewed Original ResearchConceptsPancreatic cancer casesRisk factorsPancreatic cancerProspective cohortMale sexBlack raceSEER programCancer casesPolygenic risk scoresRisk scoreProspective US cohort studyNon-modifiable risk factorsNon-O blood groupIncident pancreatic cancerUS cohort studyEnd Results ProgramPancreatic cancer riskAge-specific associationsEarly detection strategiesAge-dependent associationGenome-wide association studiesAdvanced diseaseCancer presentsCohort studyUS Surveillance
2011
Alcohol intake and risk of oesophageal adenocarcinoma: a pooled analysis from the BEACON Consortium
Freedman ND, Murray LJ, Kamangar F, Abnet CC, Cook MB, Nyrén O, Ye W, Wu AH, Bernstein L, Brown LM, Ward MH, Pandeya N, Green AC, Casson AG, Giffen C, Risch HA, Gammon MD, Chow WH, Vaughan TL, Corley DA, Whiteman DC. Alcohol intake and risk of oesophageal adenocarcinoma: a pooled analysis from the BEACON Consortium. Gut 2011, 60: 1029. PMID: 21406386, PMCID: PMC3439838, DOI: 10.1136/gut.2010.233866.Peer-Reviewed Original ResearchConceptsOesophageal squamous cell carcinomaRisk of OACOesophageal adenocarcinomaAlcohol intakeRisk of OSCCGastro-oesophageal refluxModerate alcohol intakeBody mass indexSquamous cell carcinomaSummary risk estimatesFuture prospective studiesApparent inverse associationCase-control studyHigh alcohol consumptionEsophageal Adenocarcinoma ConsortiumRandom-effects modelLogistic regression modelsCohort studyTobacco smokingMass indexOSCC casesModerate intakeOesophagogastric junctionProspective studyCell carcinoma
2010
Cigarette Smoking and Adenocarcinomas of the Esophagus and Esophagogastric Junction: A Pooled Analysis From the International BEACON Consortium
Cook MB, Kamangar F, Whiteman DC, Freedman ND, Gammon MD, Bernstein L, Brown LM, Risch HA, Ye W, Sharp L, Pandeya N, Webb PM, Wu AH, Ward MH, Giffen C, Casson AG, Abnet CC, Murray LJ, Corley DA, Nyrén O, Vaughan TL, Chow WH. Cigarette Smoking and Adenocarcinomas of the Esophagus and Esophagogastric Junction: A Pooled Analysis From the International BEACON Consortium. Journal Of The National Cancer Institute 2010, 102: 1344-1353. PMID: 20716718, PMCID: PMC2935475, DOI: 10.1093/jnci/djq289.Peer-Reviewed Original ResearchConceptsSummary odds ratiosRisk of adenocarcinomaCigarette smokingSmoking cessationOdds ratioEsophagogastric junctional adenocarcinomaEsophagogastric junctionJunctional adenocarcinomaEsophageal adenocarcinomaPopulation-based case-control studyStrong dose-response associationStudy-specific odds ratiosMultivariable logistic regression modelInternational BEACON ConsortiumDose-response associationBody mass indexCigarette smoking cessationCase-control studyWhite non-Hispanic menEsophageal Adenocarcinoma ConsortiumNon-Hispanic menLogistic regression modelsGastroesophageal refluxCohort studyCurrent smokers
2009
Molecular markers and death from prostate cancer.
Concato J, Jain D, Uchio E, Risch H, Li WW, Wells CK. Molecular markers and death from prostate cancer. Annals Of Internal Medicine 2009, 150: 595-603. PMID: 19414838, DOI: 10.7326/0003-4819-150-9-200905050-00005.Peer-Reviewed Original ResearchConceptsProstate-specific antigen levelProstate cancerLong-term riskAntigen levelsMicrovessel densityMedian prostate-specific antigen levelIncreased long-term riskVeterans Affairs Healthcare SystemIncident prostate cancerObservational cohort studyProportional hazards analysisTime of diagnosisHigher microvessel densityVeterans Health AdministrationBcl-2Years of ageProstate cancer biopsiesClinical care recordsClinical characteristicsCohort studyPatient ageMedian ageComorbid conditionsHistologic gradeResidual confounding
2000
Prepregnancy body mass index and gestational weight gain as risk factors for preeclampsia and transient hypertension
Saftlas A, Wang W, Risch H, Woolson R, Hsu C, Bracken M. Prepregnancy body mass index and gestational weight gain as risk factors for preeclampsia and transient hypertension. Annals Of Epidemiology 2000, 10: 475. PMID: 11018413, DOI: 10.1016/s1047-2797(00)00167-8.Peer-Reviewed Original ResearchPrepregnancy body mass indexGestational weight gainBody mass indexRisk of preeclampsiaTransient hypertensionRisk factorsWeight gainObese womenMass indexHigh gestational weight gainNormal BMI subjectsProspective cohort studyStrong risk factorImmediate postpartum periodMild risk factorDelivery chartsUnderweight womenCohort studyPrepregnancy obesityBMI categoriesWeeks' gestationHighest quartilePrenatal careObserved weight gainPostpartum period