2016
Risk Prediction for Epithelial Ovarian Cancer in 11 United States–Based Case-Control Studies: Incorporation of Epidemiologic Risk Factors and 17 Confirmed Genetic Loci
Clyde MA, Weber R, Iversen ES, Poole EM, Doherty JA, Goodman MT, Ness RB, Risch HA, Rossing MA, Terry KL, Wentzensen N, Whittemore AS, Anton-Culver H, Bandera EV, Berchuck A, Carney ME, Cramer DW, Cunningham JM, Cushing-Haugen KL, Edwards RP, Fridley BL, Goode EL, Lurie G, McGuire V, Modugno F, Moysich KB, Olson SH, Pearce CL, Pike MC, Rothstein JH, Sellers TA, Sieh W, Stram D, Thompson PJ, Vierkant RA, Wicklund KG, Wu AH, Ziogas A, Tworoger SS, Schildkraut JM. Risk Prediction for Epithelial Ovarian Cancer in 11 United States–Based Case-Control Studies: Incorporation of Epidemiologic Risk Factors and 17 Confirmed Genetic Loci. American Journal Of Epidemiology 2016, 184: 579-589. PMID: 27698005, PMCID: PMC5065620, DOI: 10.1093/aje/kww091.Peer-Reviewed Original ResearchConceptsEpidemiologic risk factorsEpithelial ovarian cancerYears of ageRisk factorsAbsolute riskOvarian cancerInvasive epithelial ovarian cancerCase-control studyOvarian Cancer Association ConsortiumHierarchical logistic regression modelsRisk prediction modelLogistic regression modelsProspective data setSignificant single nucleotide polymorphismsCase-control statusControl studyRisk predictionSingle nucleotide polymorphismsAgeCancerLow discriminatory powerWomenAUCRegression modelsNucleotide polymorphisms
2015
Joint Effect of Genotypic and Phenotypic Features of Reproductive Factors on Endometrial Cancer Risk
Wang Z, Risch H, Lu L, Irwin ML, Mayne S, Schwartz P, Rutherford T, De Vivo I, Yu H. Joint Effect of Genotypic and Phenotypic Features of Reproductive Factors on Endometrial Cancer Risk. Scientific Reports 2015, 5: 15582. PMID: 26498156, PMCID: PMC4620445, DOI: 10.1038/srep15582.Peer-Reviewed Original ResearchConceptsEndometrial cancer riskEndometrial cancerCancer riskEstrogen exposureEndometrial cancer patientsTime of studyGenetic risk scorePotential confoundersCancer patientsMenstrual cycleReproductive factorsRisk scorePossible markerMajor causeCancerMenopauseObesityPhenotypic featuresRiskPopulation controlsAgeMenarcheWomenExposureTNMC
1993
A hospital-based case-control study of breast-cancer risk factors by estrogen and progesterone receptor status
Yoo K, Tajima K, Miura S, Yoshida M, Murai H, Kuroishi T, Lee Y, Risch H, Dubrow R. A hospital-based case-control study of breast-cancer risk factors by estrogen and progesterone receptor status. Cancer Causes & Control 1993, 4: 39-44. PMID: 8431529, DOI: 10.1007/bf00051712.Peer-Reviewed Original ResearchConceptsHospital-based case-control studyBreast cancer risk factorsProgesterone receptor statusCase-control studyEstrogen receptorRisk factorsBreast cancerPR statusReceptor statusPR-negative breast cancerER-negative breast cancerFull-term pregnancyPR-negative casesBreast cancer casesCancer-free controlsSignificant differencesER statusMenstrual regularityEtiologic distinctionsBorderline differenceNegative casesCancerStatusAgePercent
1989
Mortality from Breast Cancer after Irradiation during Fluoroscopic Examinations in Patients Being Treated for Tuberculosis
Miller A, Howe G, Sherman G, Lindsay J, Yaffe M, Dinner P, Risch H, Preston D. Mortality from Breast Cancer after Irradiation during Fluoroscopic Examinations in Patients Being Treated for Tuberculosis. New England Journal Of Medicine 1989, 321: 1285-1289. PMID: 2797101, DOI: 10.1056/nejm198911093211902.Peer-Reviewed Original ResearchConceptsBreast cancerRelative riskFluoroscopic examinationRadiation-induced breast cancerFirst exposureLinear dose-response relationUse of mammographyYears of ageDose-response relationNumber of deathsTherapeutic pneumothoraxAsymptomatic womenExcess riskLifetime riskAdditive riskCancerWomenSubstantial proportionSmall benefitAgeRadiation dosesRiskTuberculosisMortalityExposure