2019
Bayesian Estimation of Genetic Regulatory Effects in High-throughput Reporter Assays
Majoros WH, Kim YS, Barrera A, Li F, Wang X, Cunningham SJ, Johnson GD, Guo C, Lowe WL, Scholtens DM, Hayes MG, Reddy TE, Allen AS. Bayesian Estimation of Genetic Regulatory Effects in High-throughput Reporter Assays. Bioinformatics 2019, 36: 331-338. PMID: 31368479, PMCID: PMC7999138, DOI: 10.1093/bioinformatics/btz545.Peer-Reviewed Original ResearchConceptsHigh-throughput reporterBiological replicatesGenetic regulatory effectsAdditional biological replicatesGenetic association testsAllelic effectsReporter geneGene expressionSequencing coverageDisease mutationsDisease-causing variantsRegulatory differencesLinkage disequilibriumGenetic variantsExperimental replicatesRegulatory effectsPoisson binomial distributionAllele frequenciesPatient's DNASupplementary dataBayesian hierarchical modelBayesian estimationRare variantsReporterDNA
2017
Genetic Polymorphisms of CFH and ARMS2 Do Not Predict Response to Antioxidants and Zinc in Patients with Age-Related Macular Degeneration Independent Statistical Evaluations of Data from the Age-Related Eye Disease Study
Assel MJ, Li F, Wang Y, Allen AS, Baggerly KA, Vickers AJ. Genetic Polymorphisms of CFH and ARMS2 Do Not Predict Response to Antioxidants and Zinc in Patients with Age-Related Macular Degeneration Independent Statistical Evaluations of Data from the Age-Related Eye Disease Study. Ophthalmology 2017, 125: 391-397. PMID: 29032853, PMCID: PMC5820191, DOI: 10.1016/j.ophtha.2017.09.008.Peer-Reviewed Original ResearchConceptsAge-related macular degenerationAdvanced age-related macular degenerationEye Disease StudyGenotype-treatment interactionDisease StudyHigh-risk patientsStandard careAMD progressionBaseline predictorsMacular degenerationTreatment responseGenotype subgroupsAREDS participantsPatientsGenetic polymorphismsSingle nucleotide polymorphismsCategory 1Negative resultsAgePopulation of interestTreatmentMultiple testingProgressionNucleotide polymorphismsAntioxidants