2024
Assessing treatment effect heterogeneity in the presence of missing effect modifier data in cluster-randomized trials
Blette B, Halpern S, Li F, Harhay M. Assessing treatment effect heterogeneity in the presence of missing effect modifier data in cluster-randomized trials. Statistical Methods In Medical Research 2024, 33: 909-927. PMID: 38567439, PMCID: PMC11041086, DOI: 10.1177/09622802241242323.Peer-Reviewed Original ResearchConceptsMultilevel multiple imputationHeterogeneous treatment effectsCluster randomized trialPotential effect modifiersMultiple imputationAssess treatment effect heterogeneityEffect modifiersTreatment effect heterogeneityComplete-case analysisMissingness mechanismIntracluster correlationSimulation studyUnder-coverageRandomized trialsEffect heterogeneityHealth StudyTreatment effectsContinuous outcomesClinical practiceImputationModel specificationMissingnessData methodsModified dataTrials
2023
Accounting for expected attrition in the planning of cluster randomized trials for assessing treatment effect heterogeneity
Tong J, Li F, Harhay M, Tong G. Accounting for expected attrition in the planning of cluster randomized trials for assessing treatment effect heterogeneity. BMC Medical Research Methodology 2023, 23: 85. PMID: 37024809, PMCID: PMC10077680, DOI: 10.1186/s12874-023-01887-8.Peer-Reviewed Original ResearchConceptsSample size methodsSample size proceduresSize proceduresTreatment effect heterogeneityHeterogeneous treatment effectsSize methodMissingness ratesSample size formulaSample size estimationMissingness indicatorsEffect heterogeneityReal-world examplesSimulation studyIntracluster correlation coefficientInflation methodSize formulaAverage treatment effectResultsSimulation resultsSample size estimatesSize estimationMissingnessSample sizeClustersEstimationFormula
2022
Missing Data
Tong G, Li F, Allen A. Missing Data. 2022, 1681-1701. DOI: 10.1007/978-3-319-52636-2_117.Peer-Reviewed Original ResearchLikelihood-based analysisMissingness modelMissingness processData mechanismAverage treatment effectStatistical methodsComplete case analysisConsistent estimatesRobust approachInverse probability weightingBiased estimatesMissingnessOutcome distributionModeling approachProbability weightingData processSensitivity analysisOutcome modelModelEstimatesBrief discussionPractical considerationsInferenceApproachImputation
2019
Missing Data
Tong G, Li F, Allen A. Missing Data. 2019, 1-21. DOI: 10.1007/978-3-319-52677-5_117-1.Peer-Reviewed Original ResearchLikelihood-based analysisMissingness modelMissingness processData mechanismAverage treatment effectStatistical methodsComplete case analysisConsistent estimatesRobust approachInverse probability weightingBiased estimatesMissingnessOutcome distributionModeling approachProbability weightingData processSensitivity analysisOutcome modelModelEstimatesBrief discussionPractical considerationsInferenceApproachImputation