2019
Glioma risk associated with extent of estimated European genetic ancestry in African Americans and Hispanics
Ostrom QT, Egan KM, Nabors LB, Gerke T, Thompson RC, Olson JJ, LaRocca R, Chowdhary S, Eckel‐Passow J, Armstrong G, Wiencke JK, Bernstein JL, Claus EB, Il'yasova D, Johansen C, Lachance DH, Lai RK, Merrell RT, Olson SH, Sadetzki S, Schildkraut JM, Shete S, Houlston RS, Jenkins RB, Wrensch MR, Melin B, Amos CI, Huse JT, Barnholtz‐Sloan J, Bondy ML. Glioma risk associated with extent of estimated European genetic ancestry in African Americans and Hispanics. International Journal Of Cancer 2019, 146: 739-748. PMID: 30963577, PMCID: PMC6785354, DOI: 10.1002/ijc.32318.Peer-Reviewed Original ResearchTranscriptome-wide association study identifies new candidate susceptibility genes for glioma
Atkins I, Kinnersley B, Ostrom QT, Labreche K, Il'yasova D, Armstrong GN, Eckel-Passow JE, Schoemaker MJ, Nöthen MM, Barnholtz-Sloan JS, Swerdlow AJ, Simon M, Rajaraman P, Chanock SJ, Shildkraut J, Bernstein JL, Hoffmann P, Jöckel KH, Lai RK, Claus EB, Olson SH, Johansen C, Wrensch MR, Melin B, Jenkins RB, Sanson M, Bondy ML, Houlston RS. Transcriptome-wide association study identifies new candidate susceptibility genes for glioma. Cancer Research 2019, 79: canres.2888.2018. PMID: 30709929, PMCID: PMC6522343, DOI: 10.1158/0008-5472.can-18-2888.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesTranscriptome-wide association studyNovel risk lociRisk lociAssociation studiesCausal genesGenotype-Tissue Expression project dataNew candidate susceptibility genesGlioma risk variantsGWAS-identified variantsGWAS summary statisticsGlioma risk lociBonferroni-corrected significance levelCandidate susceptibility genesGWAS lociNew genesNovel lociGene expressionGenesLociSusceptibility variantsSusceptibility genesRisk variantsGlioma tumorigenesisNon-GBM tumorsAspirin, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), and Glioma Risk: Original Data from the Glioma International Case-Control Study and a Meta-Analysis
Amirian ES, Ostrom QT, Armstrong GN, Lai RK, Gu X, Jacobs DI, Jalali A, Claus EB, Barnholtz-Sloan JS, Il'yasova D, Schildkraut JM, Ali-Osman F, Sadetzki S, Jenkins RB, Lachance DH, Olson SH, Bernstein JL, Merrell RT, Wrensch MR, Johansen C, Houlston RS, Scheurer ME, Shete S, Amos CI, Melin B, Bondy ML. Aspirin, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), and Glioma Risk: Original Data from the Glioma International Case-Control Study and a Meta-Analysis. Cancer Epidemiology Biomarkers & Prevention 2019, 28: cebp.0702.2018. PMID: 30482874, PMCID: PMC6401283, DOI: 10.1158/1055-9965.epi-18-0702.Peer-Reviewed Original ResearchLonger genotypically-estimated leukocyte telomere length is associated with increased meningioma risk
Muskens IS, Hansen HM, Smirnov IV, Molinaro AM, Bondy ML, Schildkraut JM, Wrensch M, Wiemels JL, Claus EB. Longer genotypically-estimated leukocyte telomere length is associated with increased meningioma risk. Journal Of Neuro-Oncology 2019, 142: 479-487. PMID: 30796745, PMCID: PMC6482066, DOI: 10.1007/s11060-019-03119-w.Peer-Reviewed Original ResearchConceptsMeningioma riskBrain tumorsNon-malignant brain tumoursMalignant brain tumorsEtiology of meningiomaHealthy controlsOdds ratioMeningioma patientsMeningioma casesSurvival rateLogistic regressionMeningiomasGermline DNATelomere lengthTumorsMultiple testingRiskEuropean ancestryWestern European ancestryPatientsPathophysiologyLymphocytesConclusionIncreasedEtiologyControl
2018
Genome-wide association analysis identifies a meningioma risk locus at 11p15.5
Claus EB, Cornish AJ, Broderick P, Schildkraut JM, Dobbins SE, Holroyd A, Calvocoressi L, Lu L, Hansen HM, Smirnov I, Walsh KM, Schramm J, Hoffmann P, Nöthen MM, Jöckel KH, Swerdlow A, Larsen SB, Johansen C, Simon M, Bondy M, Wrensch M, Houlston RS, Wiemels JL. Genome-wide association analysis identifies a meningioma risk locus at 11p15.5. Neuro-Oncology 2018, 20: 1485-1493. PMID: 29762745, PMCID: PMC6176799, DOI: 10.1093/neuonc/noy077.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBiomarkers, TumorCase-Control StudiesChromosomes, Human, Pair 11FemaleFollow-Up StudiesGenetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansLinkage DisequilibriumMaleMeningeal NeoplasmsMeningiomaMiddle AgedPolymorphism, Single NucleotidePrognosisRisk FactorsYoung AdultConceptsGenome-wide association studiesRisk lociGenome-wide association analysisSusceptibility lociNeural crest-derived structuresSignificant heritable basisNumber of genesIndependent sample seriesNew susceptibility lociHeritable basisGenetic basisGenome ProjectAssociation studiesAssociation analysisLinkage disequilibriumLociMeningioma developmentReference panelPolygenic modelCentral roleUK10K dataAdult brain tumorsRIC8AMeningeal coveringsGenes
2017
Quality of life after surgery for intracranial meningioma
Benz LS, Wrensch MR, Schildkraut JM, Bondy ML, Warren JL, Wiemels JL, Claus EB. Quality of life after surgery for intracranial meningioma. Cancer 2017, 124: 161-166. PMID: 28902404, PMCID: PMC6415762, DOI: 10.1002/cncr.30975.Peer-Reviewed Original ResearchConceptsMedical Outcomes Study Short Form-36 Health SurveyShort Form-36 Health SurveyGeneral healthy populationCase-control studyLong-term qualityCase/control statusResidents of ConnecticutDomains of PhysicalRole PhysicalRole EmotionalInitial diagnosisQOL outcomesHealthy controlsClinical significanceHealth SurveyMeningioma casesIntracranial meningiomasCurrent studyHealthy populationControl statusTelephone interviewsPatientsMental healthMeningiomasSignificant decrease
2015
The Glioma International Case-Control Study: A Report From the Genetic Epidemiology of Glioma International Consortium
Amirian ES, Armstrong GN, Zhou R, Lau CC, Claus EB, Barnholtz-Sloan JS, Il'yasova D, Schildkraut J, Ali-Osman F, Sadetzki S, Johansen C, Houlston RS, Jenkins RB, Lachance D, Olson SH, Bernstein JL, Merrell RT, Wrensch MR, Davis FG, Lai R, Shete S, Amos CI, Scheurer ME, Aldape K, Alafuzoff I, Brännström T, Broholm H, Collins P, Giannini C, Rosenblum M, Tihan T, Melin BS, Bondy ML. The Glioma International Case-Control Study: A Report From the Genetic Epidemiology of Glioma International Consortium. American Journal Of Epidemiology 2015, 183: 85-91. PMID: 26656478, PMCID: PMC4706682, DOI: 10.1093/aje/kwv235.Peer-Reviewed Original ResearchConceptsInternational case-control studyCase-control studyGlioma studiesGlioma International Case-Control StudyFatal brain cancerGenetic epidemiologyEtiological factorsBlood samplesGene-environment interactionsRetrospective exposure assessmentTumor subtypesBrain cancerMultiple data collection sitesSmall sample sizeBiospecimen collectionExposure assessmentInternational ConsortiumEpidemiologyCommon protocolSample sizeData collection sites
2012
Dental x‐rays and risk of meningioma
Claus EB, Calvocoressi L, Bondy ML, Schildkraut JM, Wiemels JL, Wrensch M. Dental x‐rays and risk of meningioma. Cancer 2012, 118: 4530-4537. PMID: 22492363, PMCID: PMC3396782, DOI: 10.1002/cncr.26625.Peer-Reviewed Original ResearchConceptsRisk of meningiomaDental X-raysModifiable risk factorsIntracranial meningiomasRisk factorsAge 20Population-based case-control studyMain outcome measuresPrimary brain tumorsCase-control studyGreater frequencyPanorex filmsTumor locationBitewing examinationOutcome measuresElevated riskBrain tumorsControl groupMeningiomasYounger ageRadiation exposureAge 10AgePatientsRisk
2011
Family and personal medical history and risk of meningioma.
Claus EB, Calvocoressi L, Bondy ML, Schildkraut JM, Wiemels JL, Wrensch M. Family and personal medical history and risk of meningioma. Journal Of Neurosurgery 2011, 115: 1072-7. PMID: 21780859, PMCID: PMC3241000, DOI: 10.3171/2011.6.jns11129.Peer-Reviewed Original ResearchConceptsFirst-degree family historyPersonal medical historyMedical historyFamily historyMeningioma riskEpidemiology of meningiomaPrimary brain tumorsCase-control studyRisk of meningiomaUterine fibroid tumorsImmune conditionsThyroid cancerYoungest caseBreast cancerRole of hormonesBrain tumorsFibroid tumorsImmune systemControl individualsPatientsMeningiomasInfluence of geneticsStrong associationFurther studiesTumors
1991
Genetic analysis of breast cancer in the cancer and steroid hormone study.
Claus EB, Risch N, Thompson WD. Genetic analysis of breast cancer in the cancer and steroid hormone study. American Journal Of Human Genetics 1991, 48: 232-42. PMID: 1990835, PMCID: PMC1683001.Peer-Reviewed Original ResearchConceptsCumulative lifetime riskBreast cancerLifetime riskSteroid Hormone StudyCase-control studyAge-specific riskBreast cancer casesProportion of casesInterviews of casesCancer casesFamily historyWomen's ageHormone StudyYounger ageCancerDisease controlGreater riskFamilial riskAgeSusceptibility allelesRiskNoncarriersAutosomal dominant alleleGenetic modelsYears