2021
A molecularly integrated grade for meningioma
Driver J, Hoffman SE, Tavakol S, Woodward E, Maury EA, Bhave V, Greenwald NF, Nassiri F, Aldape K, Zadeh G, Choudhury A, Vasudevan HN, Magill ST, Raleigh DR, Abedalthagafi M, Aizer AA, Alexander BM, Ligon KL, Reardon DA, Wen PY, Al-Mefty O, Ligon AH, Dubuc AM, Beroukhim R, Claus EB, Dunn IF, Santagata S, Bi W. A molecularly integrated grade for meningioma. Neuro-Oncology 2021, 24: 796-808. PMID: 34508644, PMCID: PMC9071299, DOI: 10.1093/neuonc/noab213.Peer-Reviewed Original ResearchConceptsMeningioma patientsWHO gradeGrading systemCommon primary intracranial tumorWorld Health Organization gradeProgression-free survivalAdditional prognostic informationPrimary intracranial tumorsCox proportional hazardsGrading schemeTime-dependent areaSurgical resectionChromosomal copy-number dataClinical behaviorHistopathology featuresPrognostic informationPatient managementIntracranial tumorsDiscovery cohortClinical careIndependent cohortMitotic countPatientsProportional hazardsMeningiomas
2019
Longitudinal molecular trajectories of diffuse glioma in adults
Barthel FP, Johnson KC, Varn FS, Moskalik AD, Tanner G, Kocakavuk E, Anderson KJ, Abiola O, Aldape K, Alfaro KD, Alpar D, Amin SB, Ashley DM, Bandopadhayay P, Barnholtz-Sloan JS, Beroukhim R, Bock C, Brastianos PK, Brat DJ, Brodbelt AR, Bruns AF, Bulsara KR, Chakrabarty A, Chakravarti A, Chuang JH, Claus EB, Cochran EJ, Connelly J, Costello JF, Finocchiaro G, Fletcher MN, French PJ, Gan HK, Gilbert MR, Gould PV, Grimmer MR, Iavarone A, Ismail A, Jenkinson MD, Khasraw M, Kim H, Kouwenhoven MCM, LaViolette PS, Li M, Lichter P, Ligon KL, Lowman AK, Malta TM, Mazor T, McDonald KL, Molinaro AM, Nam DH, Nayyar N, Ng HK, Ngan CY, Niclou SP, Niers JM, Noushmehr H, Noorbakhsh J, Ormond DR, Park CK, Poisson LM, Rabadan R, Radlwimmer B, Rao G, Reifenberger G, Sa JK, Schuster M, Shaw BL, Short SC, Smitt PAS, Sloan AE, Smits M, Suzuki H, Tabatabai G, Van Meir EG, Watts C, Weller M, Wesseling P, Westerman BA, Widhalm G, Woehrer A, Yung WKA, Zadeh G, Huse JT, De Groot JF, Stead LF, Verhaak RGW. Longitudinal molecular trajectories of diffuse glioma in adults. Nature 2019, 576: 112-120. PMID: 31748746, PMCID: PMC6897368, DOI: 10.1038/s41586-019-1775-1.Peer-Reviewed Original ResearchConceptsAdult patientsDiffuse gliomasRecurrent gliomaOverall survivalPoor outcomeCurrent therapiesChromosome arms 1p/19qAcquired alterationsMajor subtypesTherapeutic resistanceGliomasGlioma developmentGene alterationsIDH mutationsGlioma subtypesPatientsHypermutator phenotypeDriver genesSubtypesClinical annotationSurvivalSubclonal selectionCell cycleAlterationsLittle evidenceSocial media partnerships with patient organizations for neuro-oncology patient recruitment
Claus EB, Feliciano J, Benz LS, Calvocoressi L. Social media partnerships with patient organizations for neuro-oncology patient recruitment. Neuro-Oncology Practice 2019, 7: 143-151. PMID: 32626583, PMCID: PMC7318861, DOI: 10.1093/nop/npz049.Peer-Reviewed Original ResearchNeuro-oncology patientsPatient organizationsNational Cancer Institute's SurveillanceEnd Results (SEER) dataTumor RegistryPathology reportsTreatment responsePatient recruitmentEpidemiologic studiesNeuro-oncologyPatientsYale University SchoolSaliva specimenSuccessful enrollmentEnrollment methodsDisease etiologyAssociation websitesRegistryPublic healthUniversity SchoolParticipant populationResult dataSurveillanceOnline questionnaireParticipantsLonger genotypically-estimated leukocyte telomere length is associated with increased meningioma risk
Muskens IS, Hansen HM, Smirnov IV, Molinaro AM, Bondy ML, Schildkraut JM, Wrensch M, Wiemels JL, Claus EB. Longer genotypically-estimated leukocyte telomere length is associated with increased meningioma risk. Journal Of Neuro-Oncology 2019, 142: 479-487. PMID: 30796745, PMCID: PMC6482066, DOI: 10.1007/s11060-019-03119-w.Peer-Reviewed Original ResearchConceptsMeningioma riskBrain tumorsNon-malignant brain tumoursMalignant brain tumorsEtiology of meningiomaHealthy controlsOdds ratioMeningioma patientsMeningioma casesSurvival rateLogistic regressionMeningiomasGermline DNATelomere lengthTumorsMultiple testingRiskEuropean ancestryWestern European ancestryPatientsPathophysiologyLymphocytesConclusionIncreasedEtiologyControl
2017
Quality of life after surgery for intracranial meningioma
Benz LS, Wrensch MR, Schildkraut JM, Bondy ML, Warren JL, Wiemels JL, Claus EB. Quality of life after surgery for intracranial meningioma. Cancer 2017, 124: 161-166. PMID: 28902404, PMCID: PMC6415762, DOI: 10.1002/cncr.30975.Peer-Reviewed Original ResearchConceptsMedical Outcomes Study Short Form-36 Health SurveyShort Form-36 Health SurveyGeneral healthy populationCase-control studyLong-term qualityCase/control statusResidents of ConnecticutDomains of PhysicalRole PhysicalRole EmotionalInitial diagnosisQOL outcomesHealthy controlsClinical significanceHealth SurveyMeningioma casesIntracranial meningiomasCurrent studyHealthy populationControl statusTelephone interviewsPatientsMental healthMeningiomasSignificant decrease
2015
Clinical implementation of integrated whole-genome copy number and mutation profiling for glioblastoma
Ramkissoon SH, Bi WL, Schumacher SE, Ramkissoon LA, Haidar S, Knoff D, Dubuc A, Brown L, Burns M, Cryan JB, Abedalthagafi M, Kang YJ, Schultz N, Reardon DA, Lee EQ, Rinne ML, Norden AD, Nayak L, Ruland S, Doherty LM, LaFrankie DC, Horvath M, Aizer AA, Russo A, Arvold ND, Claus EB, Al-Mefty O, Johnson MD, Golby AJ, Dunn IF, Chiocca EA, Trippa L, Santagata S, Folkerth RD, Kantoff P, Rollins BJ, Lindeman NI, Wen PY, Ligon AH, Beroukhim R, Alexander BM, Ligon KL. Clinical implementation of integrated whole-genome copy number and mutation profiling for glioblastoma. Neuro-Oncology 2015, 17: 1344-1355. PMID: 25754088, PMCID: PMC4578577, DOI: 10.1093/neuonc/nov015.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overBrain NeoplasmsChildChild, PreschoolComparative Genomic HybridizationDNA Copy Number VariationsFemaleGene Expression ProfilingGenome-Wide Association StudyGenotypeGlioblastomaHumansInfantIsocitrate DehydrogenaseMaleMiddle AgedMutationProspective StudiesPTEN PhosphohydrolaseTumor Suppressor Protein p53Young AdultConceptsClinical trialsBrain tumorsGlioblastoma patientsClinical settingClinical Laboratory Improvement AmendmentsParaffin-embedded samplesWhole-genome array comparative genomic hybridizationWhole gene sequencingTherapeutic trialsWhole-genome copy numberClinical testing resultsPatientsClinical diagnosisMutation profilingIntegral biomarkerArray comparative genomic hybridizationGlioblastomaClinical implementationTrialsComparative genomic hybridizationTumor suppressor inactivationCopy numberTumorsFFPE samplesDiagnostic laboratoriesSurvival and low-grade glioma: the emergence of genetic information.
Claus EB, Walsh KM, Wiencke JK, Molinaro AM, Wiemels JL, Schildkraut JM, Bondy ML, Berger M, Jenkins R, Wrensch M. Survival and low-grade glioma: the emergence of genetic information. Neurosurgical FOCUS 2015, 38: e6. PMID: 25552286, PMCID: PMC4361022, DOI: 10.3171/2014.10.focus12367.Peer-Reviewed Original ResearchConceptsLow-grade gliomasHigh-grade gliomasLGG patientsRefining risk stratificationEnd Results ProgramUniformly fatal diseaseRole of tumorNational Cancer InstituteOverall survivalYounger patientsRisk stratificationClinical variablesResults ProgramClinical managementClinical trialsSuch tumorsCurrent treatmentSurvival trendsTumor markersBetter survivalCancer InstitutePatientsFatal diseaseGliomasTumor expression profiles
2012
Dental x‐rays and risk of meningioma
Claus EB, Calvocoressi L, Bondy ML, Schildkraut JM, Wiemels JL, Wrensch M. Dental x‐rays and risk of meningioma. Cancer 2012, 118: 4530-4537. PMID: 22492363, PMCID: PMC3396782, DOI: 10.1002/cncr.26625.Peer-Reviewed Original ResearchConceptsRisk of meningiomaDental X-raysModifiable risk factorsIntracranial meningiomasRisk factorsAge 20Population-based case-control studyMain outcome measuresPrimary brain tumorsCase-control studyGreater frequencyPanorex filmsTumor locationBitewing examinationOutcome measuresElevated riskBrain tumorsControl groupMeningiomasYounger ageRadiation exposureAge 10AgePatientsRisk
2011
Neurosurgical management of metastases in the central nervous system
Claus EB. Neurosurgical management of metastases in the central nervous system. Nature Reviews Clinical Oncology 2011, 9: 79-86. PMID: 22143137, DOI: 10.1038/nrclinonc.2011.179.Peer-Reviewed Original ResearchConceptsMetastatic cancerCurrent randomized clinical trialsCentral nervous system involvementNervous system involvementRandomized clinical trialsTreatment of patientsCentral nervous systemCNS metastasesMultimodality therapySpinal metastasesNeurosurgical treatmentSystem involvementClinical trialsNeurosurgical interventionNeurosurgical managementNervous systemMetastasisPatientsCancerTreatmentTherapyBrainTrialsIntegral componentFamily and personal medical history and risk of meningioma.
Claus EB, Calvocoressi L, Bondy ML, Schildkraut JM, Wiemels JL, Wrensch M. Family and personal medical history and risk of meningioma. Journal Of Neurosurgery 2011, 115: 1072-7. PMID: 21780859, PMCID: PMC3241000, DOI: 10.3171/2011.6.jns11129.Peer-Reviewed Original ResearchConceptsFirst-degree family historyPersonal medical historyMedical historyFamily historyMeningioma riskEpidemiology of meningiomaPrimary brain tumorsCase-control studyRisk of meningiomaUterine fibroid tumorsImmune conditionsThyroid cancerYoungest caseBreast cancerRole of hormonesBrain tumorsFibroid tumorsImmune systemControl individualsPatientsMeningiomasInfluence of geneticsStrong associationFurther studiesTumors