1998
A prospective study of methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms, and risk of colorectal adenoma.
Chen J, Giovannucci E, Hankinson SE, Ma J, Willett WC, Spiegelman D, Kelsey KT, Hunter DJ. A prospective study of methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms, and risk of colorectal adenoma. Carcinogenesis 1998, 19: 2129-2132. PMID: 9886567, DOI: 10.1093/carcin/19.12.2129.Peer-Reviewed Original ResearchConceptsVal/Val polymorphismColorectal adenomasMethylenetetrahydrofolate reductase (MTHFR) geneHealth StudyProspective Nurses' Health StudyNurses' Health StudyRisk of adenomaVal polymorphismSynthase gene polymorphismsMethionine synthase geneLack of associationPolyp casesProspective studyColorectal cancerGly polymorphismBenign adenomasGene polymorphismsAdenomasColorectal tumorigenesisMalignant transformationFunctional polymorphismsMethylenetetrahydrofolate reductaseMethionine synthase gene polymorphismsRiskPolymorphism
1996
A methylenetetrahydrofolate reductase polymorphism and the risk of colorectal cancer.
Chen J, Giovannucci E, Kelsey K, Rimm EB, Stampfer MJ, Colditz GA, Spiegelman D, Willett WC, Hunter DJ. A methylenetetrahydrofolate reductase polymorphism and the risk of colorectal cancer. Cancer Research 1996, 56: 4862-4. PMID: 8895734.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedColorectal NeoplasmsEthanolFolic AcidGenotypeHumansMaleMethionineMethylenetetrahydrofolate Reductase (NADPH2)Middle AgedOxidoreductases Acting on CH-NH Group DonorsPolymorphism, GeneticProspective StudiesRisk FactorsConceptsVal/Val individualsVal/Val genotypeColorectal cancerOdds ratioVal genotypeHealth Professionals FollowColorectal cancer riskStrong risk factorHigh dietary intakeCase-control studyMore alcoholic drinksMethylenetetrahydrofolate reductase (MTHFR) polymorphismsVariant homozygous genotypeMethylenetetrahydrofolate reductase (MTHFR) geneProfessionals FollowAlcohol intakeInverse associationRisk factorsDietary intakeReduced incidenceMTHFR genotypeCancer riskBlood samplesAlcohol consumptionOncogenic alterations