2004
Plasma Lipid and Lipoprotein Levels during the Follicular and Luteal Phases of the Menstrual Cycle
Barnett JB, Woods MN, Lamon-Fava S, Schaefer EJ, McNamara JR, Spiegelman D, Hertzmark E, Goldin B, Longcope C, Gorbach SL. Plasma Lipid and Lipoprotein Levels during the Follicular and Luteal Phases of the Menstrual Cycle. The Journal Of Clinical Endocrinology & Metabolism 2004, 89: 776-782. PMID: 14764796, DOI: 10.1210/jc.2003-030506.Peer-Reviewed Original ResearchConceptsMenstrual cycle phaseLuteal phasePremenopausal womenFollicular phaseMenstrual cycleTotal cholesterol/high-density lipoprotein cholesterolLow-density lipoprotein cholesterol levelsHigh-density lipoprotein cholesterolCoronary heart disease riskTotal cholesterol/HDLPremenopausal Caucasian womenLipoprotein cholesterol levelsHeart disease riskBody mass indexCholesterol/HDLLevels of LDLSex hormone levelsLevels of estradiolLipoprotein cholesterolLipoprotein levelsMass indexEstrogen levelsLipoprotein profilePlasma lipidsCholesterol levels
2001
Association of genetic polymorphisms in UGT1A1 with breast cancer and plasma hormone levels.
Guillemette C, De Vivo I, Hankinson SE, Haiman CA, Spiegelman D, Housman DE, Hunter DJ. Association of genetic polymorphisms in UGT1A1 with breast cancer and plasma hormone levels. Cancer Epidemiology Biomarkers & Prevention 2001, 10: 711-4. PMID: 11401924.Peer-Reviewed Original ResearchConceptsHealth Study cohortBreast cancer riskHormone levelsBreast cancerUGT1A1 genotypeCancer riskNurses' Health Study cohortPremenopausal breast cancer riskUDP-glucuronosyltransferasesBody mass indexCase-control studyPlasma hormone levelsUGT1A1 promoter polymorphismCommon insertion/deletion polymorphismInsertion/deletion polymorphismPostmenopausal womenHormone replacementMass indexStudy cohortEstradiol levelsEstradiol metabolismBlood drawCaucasian womenRelative riskAfrican American population
2000
A tetranucleotide repeat polymorphism in CYP19 and breast cancer risk
Haiman C, Hankinson S, Spiegelman D, De Vivo I, Colditz G, Willett W, Speizer F, Hunter D. A tetranucleotide repeat polymorphism in CYP19 and breast cancer risk. International Journal Of Cancer 2000, 87: 204-210. PMID: 10861475, DOI: 10.1002/1097-0215(20000715)87:2<204::aid-ijc8>3.0.co;2-3.Peer-Reviewed Original ResearchConceptsBreast cancer riskHealth Study cohortCase-control studyCancer riskHormone levelsNurses' Health Study cohortBreast cancer case-control studyElevated estrogen levelsAdvanced cancer casesCancer case-control studyRepeat polymorphismTetranucleotide repeat polymorphismConversion of androgensGreater frequencyKey steroidogenic enzymesSignificant greater frequencyDistant metastasisStudy cohortEstrogen levelsCYP19 allelesBreast cancerCancer casesAllele carriersEstrone sulfateNonsignificant increase
1999
Reproducibility of plasma and urinary sex hormone levels in premenopausal women over a one-year period.
Michaud DS, Manson JE, Spiegelman D, Barbieri RL, Sepkovic DW, Bradlow HL, Hankinson SE. Reproducibility of plasma and urinary sex hormone levels in premenopausal women over a one-year period. Cancer Epidemiology Biomarkers & Prevention 1999, 8: 1059-64. PMID: 10613337.Peer-Reviewed Original ResearchConceptsPremenopausal womenIntraclass correlation coefficientLuteal phaseHormone levelsBlood samplesEndogenous sex steroid hormonesUrinary sex hormone levelsUrinary sex hormonesUrinary estrogen metabolitesSex hormone levelsSex steroid hormonesSets of bloodSingle blood sampleHigh intraclass correlation coefficientsLuteal phase samplesPlasma estrogenMenstrual cycleSex hormonesPlasma estradiolBreast cancerEstrogen metabolitesEstrone sulfateUrinary 2One-year periodSteroid hormonesRelationship between Serum Estradiol Levels and the Increases in High-Density Lipoprotein Levels in Postmenopausal Women Treated with Oral Estradiol1
Walsh B, Spiegelman D, Morrissey M, Sacks F. Relationship between Serum Estradiol Levels and the Increases in High-Density Lipoprotein Levels in Postmenopausal Women Treated with Oral Estradiol1. The Journal Of Clinical Endocrinology & Metabolism 1999, 84: 985-989. PMID: 10084583, DOI: 10.1210/jcem.84.3.5571.Peer-Reviewed Original Research
1998
Plasma Sex Steroid Hormone Levels and Risk of Breast Cancer in Postmenopausal Women
Hankinson S, Willett W, Manson J, Colditz G, Hunter D, Spiegelman D, Barbieri R, Speizer F. Plasma Sex Steroid Hormone Levels and Risk of Breast Cancer in Postmenopausal Women. Journal Of The National Cancer Institute 1998, 90: 1292-1299. PMID: 9731736, DOI: 10.1093/jnci/90.17.1292.Peer-Reviewed Original ResearchConceptsSex steroid hormone levelsHormone replacement therapyBreast cancer riskPostmenopausal womenBreast cancerSteroid hormone levelsBlood collectionEstrogen levelsReplacement therapyHormone levelsCancer riskHealth StudyPrevious hormone replacement therapyPlasma sex steroid hormone levelsPostmenopausal estrogen levelsNurses' Health StudyPlasma estrogen levelsLevels of estradiolCase-control studyPlasma androgen levelsBioavailable estradiolMenopausal statusSignificant positive associationControl subjectsLowest quartile
1995
Reproducibility of plasma hormone levels in postmenopausal women over a 2-3-year period.
Hankinson SE, Manson JE, Spiegelman D, Willett WC, Longcope C, Speizer FE. Reproducibility of plasma hormone levels in postmenopausal women over a 2-3-year period. Cancer Epidemiology Biomarkers & Prevention 1995, 4: 649-54. PMID: 8547832.Peer-Reviewed Original ResearchConceptsSex hormone-binding globulinIntraclass correlation coefficientPlasma hormone levelsPostmenopausal womenBioavailable estradiolPlasma levelsFree estradiolHormone levelsHealthy postmenopausal womenHormone-binding globulinLow intraclass correlation coefficientsPostmenopausal hormonesPlasma estrogenPlasma hormonesEstrone sulfateAge 51Blood samplesEstradiolWomenHormoneAndrostenedioneProlactinAgeSample collectionMenopause