2020
Vitamin D Supplements for Prevention of Tuberculosis Infection and Disease
Ganmaa D, Uyanga B, Zhou X, Gantsetseg G, Delgerekh B, Enkhmaa D, Khulan D, Ariunzaya S, Sumiya E, Bolortuya B, Yanjmaa J, Enkhtsetseg T, Munkhzaya A, Tunsag M, Khudyakov P, Seddon JA, Marais BJ, Batbayar O, Erdenetuya G, Amarsaikhan B, Spiegelman D, Tsolmon J, Martineau AR. Vitamin D Supplements for Prevention of Tuberculosis Infection and Disease. New England Journal Of Medicine 2020, 383: 359-368. PMID: 32706534, PMCID: PMC7476371, DOI: 10.1056/nejmoa1915176.Peer-Reviewed Original ResearchConceptsVitamin D groupAcute respiratory infectionsVitamin D supplementationPlacebo groupRespiratory infectionsTuberculosis infectionD groupVitamin DTuberculosis diseaseD supplementationAdverse eventsQFT resultsPositive QFT resultWeekly oral doseVitamin D supplementsQuantiFERON-TB GoldProportion of childrenD supplementsSecondary outcomesPrimary outcomeOral doseD levelsImmune responseLower riskInfection
2013
Micronutrient supplementation and T cell-mediated immune responses in patients with tuberculosis in Tanzania
KAWAI K, MEYDANI SN, URASSA W, WU D, MUGUSI FM, SAATHOFF E, BOSCH RJ, VILLAMOR E, SPIEGELMAN D, FAWZI WW. Micronutrient supplementation and T cell-mediated immune responses in patients with tuberculosis in Tanzania. Epidemiology And Infection 2013, 142: 1505-1509. PMID: 24093552, PMCID: PMC5639693, DOI: 10.1017/s0950268813002495.Peer-Reviewed Original ResearchConceptsCell-mediated immune responsesTB patientsMicronutrient supplementationMicronutrient supplementsImmune responseProliferative responseT cell-mediated immune responsesHIV-negative TB patientsHIV-positive TB patientsLymphocyte proliferative responsesLymphocyte proliferation responseHigher proliferative responsesT cell mitogensPlacebo groupPulmonary TBTB treatmentDaily doseEligible participantsNutritional interventionTuberculosis treatmentTime of initiationClinical relevanceMicronutrient groupProliferation responsePatientsDietary Patterns, Nutrient Intake, and Sociodemographic Characteristics in HIV-Infected Tanzanian Pregnant Women
Lukmanji Z, Hertzmark E, Spiegleman D, Fawzi WW. Dietary Patterns, Nutrient Intake, and Sociodemographic Characteristics in HIV-Infected Tanzanian Pregnant Women. Ecology Of Food And Nutrition 2013, 52: 34-62. PMID: 23282190, DOI: 10.1080/03670244.2012.705768.Peer-Reviewed Original ResearchConceptsPregnant womenNutrient intakeTanzanian pregnant womenWorld Health Organization recommendationsDietary macronutrient intakeLongitudinal clinical trialsVitamin supplementationClinical trialsDietary intakeMacronutrient intakeDietary patternsDiet intakeFood composition tablesHigh riskWomen's ageSociodemographic characteristicsIntakeInadequate foodDar es SalaamWomenHIVTwo-thirdsEducation levelComposition tablesAge
2012
Predictors of stunting, wasting and underweight among Tanzanian children born to HIV-infected women
McDonald CM, Kupka R, Manji KP, Okuma J, Bosch RJ, Aboud S, Kisenge R, Spiegelman D, Fawzi WW, Duggan CP. Predictors of stunting, wasting and underweight among Tanzanian children born to HIV-infected women. European Journal Of Clinical Nutrition 2012, 66: 1265-1276. PMID: 23031850, PMCID: PMC3491141, DOI: 10.1038/ejcn.2012.136.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBody HeightBody WeightDouble-Blind MethodEducational StatusFemaleGrowth DisordersHIV InfectionsHumansInfantInfant, Low Birth WeightInfant, NewbornInfant, PrematureInfectious Disease Transmission, VerticalMaleMalnutritionPremature BirthPrevalenceProportional Hazards ModelsReference ValuesSex FactorsSocioeconomic FactorsTanzaniaThinnessWasting SyndromeYoung AdultConceptsBirth weightFirst episodeTanzanian childrenMultivariate Cox proportional hazards methodMaternal educationLow infant birth weightCox proportional hazards methodDevelopment of undernutritionInfant birth weightLow Apgar scoreModifiable risk factorsLow birth weightChild HIV infectionHuman immunodeficiency virusPredictors of stuntingRisk of undernutritionProportional hazards methodsLow maternal educationWeeks of ageMorbidity historiesApgar scoreChild transmissionMedian durationPreterm infantsHIV infection
2002
Randomized trial of vitamin supplements in relation to transmission of HIV-1 through breastfeeding and early child mortality
Fawzi WW, Msamanga GI, Hunter D, Renjifo B, Antelman G, Bang H, Manji K, Kapiga S, Mwakagile D, Essex M, Spiegelman D. Randomized trial of vitamin supplements in relation to transmission of HIV-1 through breastfeeding and early child mortality. AIDS 2002, 16: 1935-1944. PMID: 12351954, DOI: 10.1097/00002030-200209270-00011.Peer-Reviewed Original ResearchConceptsHIV-1 transmissionInfants of mothersVitamin ALower baseline lymphocyte countsHigh erythrocyte sedimentation rateChild mortalityBaseline lymphocyte countMaternal micronutrient statusHIV-free survivalErythrocyte sedimentation rateLow birthweight babiesEarly child mortalityRisk of transmissionLymphocyte countLower hemoglobinMultivitamin supplementationWeeks' gestationBirthweight babiesPregnant womenHIV-1Vitamin supplementsMultivitaminsNutritional statusMicronutrient statusMortalityVitamin A Supplements Ameliorate the Adverse Effect of HIV-1, Malaria, and Diarrheal Infections on Child Growth
Villamor E, Mbise R, Spiegelman D, Hertzmark E, Fataki M, Peterson KE, Ndossi G, Fawzi WW. Vitamin A Supplements Ameliorate the Adverse Effect of HIV-1, Malaria, and Diarrheal Infections on Child Growth. Pediatrics 2002, 109: e6-e6. PMID: 11773574, DOI: 10.1542/peds.109.1.e6.Peer-Reviewed Original ResearchConceptsMid-upper arm circumferenceMonths of ageVitamin A supplementsPersistent diarrheaHIV infectionRespiratory infectionsVitamin AArm circumferenceHIV statusStudy clinicTreatment armsA supplementsHigher mid-upper arm circumferenceHuman immunodeficiency virus (HIV) infectionInfectious diseasesAdverse effectsLow arm circumferenceEpisodes of infectionImmunodeficiency virus infectionDay of admissionIU vitamin APrevalence of vitaminChild growthConfidence intervalsSeverity of diarrhea
2001
Do HIV Type 1 RNA Levels Provide Additional Prognostic Value to CD4+ T Lymphocyte Counts in Patients with Advanced HIV Type 1 Infection?
Arduino J, Fischl M, Stanley K, Collier A, Spiegelman D. Do HIV Type 1 RNA Levels Provide Additional Prognostic Value to CD4+ T Lymphocyte Counts in Patients with Advanced HIV Type 1 Infection? AIDS Research And Human Retroviruses 2001, 17: 1099-1105. PMID: 11522179, DOI: 10.1089/088922201316912709.Peer-Reviewed Original ResearchConceptsHIV-1 RNA levelsHIV-1 disease progressionBaseline HIV-1 RNA levelsT-lymphocyte countsT lymphocytesDisease progressionLymphocyte countRNA levelsCells/Prognostic informationHigh baseline HIV-1 RNA levelsHIV type 1 RNA levelsPlasma HIV-1 RNA levelsSubsequent HIV-1 disease progressionAdvanced HIV-1 diseaseHIV Type 1 InfectionConditional logistic regression analysisDisease progression independentHIV-1 diseaseAdditional prognostic informationAdditional prognostic valueType 1 infectionCase-control studyLogistic regression analysisClinical statusDifferences in perinatal transmission among human immunodeficiency virus type 1 genotypes.
Renjifo B, Fawzi W, Mwakagile D, Hunter D, Msamanga G, Spiegelman D, Garland M, Kagoma C, Kim A, Chaplin B, Hertzmark E, Essex M. Differences in perinatal transmission among human immunodeficiency virus type 1 genotypes. Human Virology 2001, 4: 16-25. PMID: 11213929.Peer-Reviewed Original ResearchMeSH KeywordsBase SequenceCapsidCapsid ProteinsCase-Control StudiesDNA, ViralDouble-Blind MethodFemaleGag Gene Products, Human Immunodeficiency VirusGene Products, envGene Products, gagGenotypeHIV Core Protein p24HIV InfectionsHIV-1HumansInfantInfant, NewbornMolecular Sequence DataRisk FactorsViral ProteinsConceptsHIV-1 genetic subtypesCD4 cell countHIV-1 genotypesCell countGenetic subtypesHIV-1 subtype AHIV-1 subtype CHuman immunodeficiency virus type 1Vertical transmissionHuman immunodeficiency virus type 1 genotypesImmunodeficiency virus type 1Intersubtype recombinant virusesMaternal risk factorsLogistic regression analysisType 1 genotypeVirus type 1HIV-1 GagPerinatal transmissionSubtype CRisk factorsSubtype AHIV-1Intersubtype recombinantsType 1Differential risk
2000
Vitamin A supplements and diarrheal and respiratory tract infections among children in Dar es Salaam, Tanzania
Fawzi W, Mbise R, Spiegelman D, Fataki M, Hertzmark E, Ndossi G. Vitamin A supplements and diarrheal and respiratory tract infections among children in Dar es Salaam, Tanzania. The Journal Of Pediatrics 2000, 137: 660-667. PMID: 11060532, DOI: 10.1067/mpd.2000.110136.Peer-Reviewed Original ResearchConceptsRespiratory tract infectionsHuman immunodeficiency virusTract infectionsVitamin APlacebo-controlled trialAcute respiratory infectionsSevere watery diarrheaRisk of diarrheaEffect of vitaminDuration of episodesRapid respiratory rateLow-cost interventionAcute diarrheaRespiratory infectionsImmunodeficiency virusWatery diarrheaAdverse outcomesUndernourished childrenHigh riskDiarrheaRespiratory rateInfectionSmall riskPlaceboDar es SalaamRandomized trial of vitamin supplements in relation to vertical transmission of HIV-1 in Tanzania.
Fawzi W, Msamanga G, Hunter D, Urassa E, Renjifo B, Mwakagile D, Hertzmark E, Coley J, Garland M, Kapiga S, Antelman G, Essex M, Spiegelman D. Randomized trial of vitamin supplements in relation to vertical transmission of HIV-1 in Tanzania. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2000, 23: 246-54. PMID: 10839660, DOI: 10.1097/00126334-200003010-00006.Peer-Reviewed Original ResearchConceptsPregnant womenPolymerase chain reactionVitamin APlacebo-controlled trialPoor nutritional statusMultivitamin armHIV infectionHIV statusWeeks postpartumObservational studyHIV-1High riskHIVNutritional statusEffects of supplementsVertical transmissionChain reactionBirthMultivitaminsBabiesWomenSupplementsVitaminArmStatusRandomized Trial of Vitamin Supplements in Relation to Vertical Transmission of HIV-1 in Tanzania
Fawzi W, Msamanga G, Hunter D, Urassa E, Renjifo B, Mwakagile D, Hertzmark E, Coley J, Garland M, Kapiga S, Antelman G, Essex M, Spiegelman D. Randomized Trial of Vitamin Supplements in Relation to Vertical Transmission of HIV-1 in Tanzania. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2000, 23: 246-254. DOI: 10.1097/00042560-200003010-00006.Peer-Reviewed Original ResearchConceptsPregnant womenPolymerase chain reactionVitamin APlacebo-controlled trialPoor nutritional statusBackground Observational studiesMultivitamin armHIV infectionHIV statusWeeks postpartumObservational studyHIV-1High riskHIVNutritional statusEffects of supplementsVertical transmissionChain reactionBirthMultivitaminsBabiesWomenSupplementsVitaminArm
1999
Relationship between Serum Estradiol Levels and the Increases in High-Density Lipoprotein Levels in Postmenopausal Women Treated with Oral Estradiol1
Walsh B, Spiegelman D, Morrissey M, Sacks F. Relationship between Serum Estradiol Levels and the Increases in High-Density Lipoprotein Levels in Postmenopausal Women Treated with Oral Estradiol1. The Journal Of Clinical Endocrinology & Metabolism 1999, 84: 985-989. PMID: 10084583, DOI: 10.1210/jcem.84.3.5571.Peer-Reviewed Original ResearchRationale and Design of the Tanzania Vitamin and HIV Infection Trial
Fawzi W, Msamanga G, Spiegelman D, Urassa E, Hunter D. Rationale and Design of the Tanzania Vitamin and HIV Infection Trial. Contemporary Clinical Trials 1999, 20: 75-90. PMID: 10027501, DOI: 10.1016/s0197-2456(98)00045-2.Peer-Reviewed Original ResearchConceptsHIV infectionVitamin APregnant womenPolymerase chain reactionVitamin supplementsHIV-positive pregnant womenVertical transmissionHIV Infection TrialInfant immune functionEligible pregnant womenPlacebo-controlled trialClinical staging systemHIV-positive womenGenital tract secretionsUse of supplementsHIV diseaseMost HIVPrevention trialsViral loadMain endpointBreast milkStaging systemCohort retentionPosttest counselingTract secretionsA randomized trial of vitamin A supplements in relation to mortality among human immunodeficiency virus-infected and uninfected children in Tanzania
FAWZI W, MBISE R, HERTZMARK E, FATAKI M, HERRERA M, NDOSSI G, SPIEGELMAN D. A randomized trial of vitamin A supplements in relation to mortality among human immunodeficiency virus-infected and uninfected children in Tanzania. The Pediatric Infectious Disease Journal 1999, 18: 127-133. PMID: 10048684, DOI: 10.1097/00006454-199902000-00009.Peer-Reviewed Original ResearchMeSH KeywordsChild, PreschoolDouble-Blind MethodFemaleHIV AntibodiesHIV InfectionsHumansInfantMaleSurvival AnalysisTanzaniaVitamin AVitamin A DeficiencyConceptsUninfected childrenCause mortalityChildren ages 6 monthsMortality of HIVTrial of vitaminPlacebo-controlled trialDiarrhea-related deathsAge 6 monthsWestern blot testMonths of ageEnzyme-linked immunosorbentLow-cost interventionChildren 58HIV antibodiesHospital dischargeHIV infectionHIV statusPositive childrenStandard treatmentMean durationAntigen assaysFurther dosesHuman immunodeficiencyClinical signsNeutralization assays
1998
Vitamin A supplementation and severity of pneumonia in children admitted to the hospital in Dar es Salaam, Tanzania 1 2 3
Fawzi WW, Mbise RL, Fataki MR, Herrera MG, Kawau F, Hertzmark E, Spiegelman D, Ndossi G. Vitamin A supplementation and severity of pneumonia in children admitted to the hospital in Dar es Salaam, Tanzania 1 2 3. American Journal Of Clinical Nutrition 1998, 68: 187-192. PMID: 9665113, DOI: 10.1093/ajcn/68.1.187.Peer-Reviewed Original ResearchConceptsVitamin APlacebo groupTanzanian childrenLarge dosesAcute lower respiratory tract infectionLower respiratory tract infectionsImportant public health problemPlacebo-controlled trialRespiratory tract infectionsDay of admissionSeverity of pneumoniaBreast-feeding statusCourse of pneumoniaSevere clinical conditionMean numberPublic health problemRapid respiratory rateHospital stayTract infectionsDietary vitaminClinical conditionsProtective effectRespiratory diseaseHealth problemsNutritional statusRandomised trial of effects of vitamin supplements on pregnancy outcomes and T cell counts in HIV-1-infected women in Tanzania
Fawzi W, Msamanga G, Spiegelman D, Urassa E, McGrath N, Mwakagile D, Antelman G, Mbise R, Kapiga S, Willett W, Hunter D, Team F, Herrera G. Randomised trial of effects of vitamin supplements on pregnancy outcomes and T cell counts in HIV-1-infected women in Tanzania. The Lancet 1998, 351: 1477-1482. PMID: 9605804, DOI: 10.1016/s0140-6736(98)04197-x.Peer-Reviewed Original ResearchConceptsHIV-1-infected womenT-cell countsHIV-1 diseaseBirth outcomesVitamin APregnancy outcomesMultivitamin supplementationHIV-1-infected pregnant womenPoor micronutrient statusTrial of effectAdverse pregnancy outcomesPlacebo-controlled trialT lymphocyte subsetsAdverse birth outcomesEffects of multivitaminsSevere preterm birthsLymphocyte subsetsPreterm birthFetal deathWeeks' gestationGestational ageClinical progressionPregnant womenLow birthweightFaster progression