2011
Fatty acids in the de novo lipogenesis pathway and risk of coronary heart disease: the Cardiovascular Health Study
Wu J, Lemaitre RN, Imamura F, King IB, Song X, Spiegelman D, Siscovick DS, Mozaffarian D. Fatty acids in the de novo lipogenesis pathway and risk of coronary heart disease: the Cardiovascular Health Study. American Journal Of Clinical Nutrition 2011, 94: 431-438. PMID: 21697077, PMCID: PMC3142722, DOI: 10.3945/ajcn.111.012054.Peer-Reviewed Original ResearchConceptsCoronary heart diseaseNonfatal myocardial infarctionSudden cardiac arrestFatal coronary heart diseaseTotal coronary heart diseaseIncident coronary heart diseaseDe novo lipogenesisHigh riskCHD eventsHeart diseaseMultivariable-adjusted Cox proportional hazardsCommunity-based prospective studySecondary analysisCardiovascular disease risk factorsCardiovascular Health StudyDisease risk factorsFatty acidsCox proportional hazardsDe novo lipogenesis pathwayCHD deathCHD outcomesProspective studyCardiac arrestMyocardial infarctionMedical records
2005
Alcohol consumption and high-density lipoprotein levels: the effect of ADH1C genotype, gender and menopausal status
Hines LM, Hunter DJ, Stampfer MJ, Spiegelman D, Chu NF, Rifai N, Hankinson SE, Rimm EB. Alcohol consumption and high-density lipoprotein levels: the effect of ADH1C genotype, gender and menopausal status. Atherosclerosis 2005, 182: 293-300. PMID: 16051248, DOI: 10.1016/j.atherosclerosis.2005.02.005.Peer-Reviewed Original ResearchConceptsHigh-density lipoprotein levelsPostmenopausal hormonesPostmenopausal womenModerate alcohol consumptionHDL levelsOlder-aged menPremenopausal womenAlcohol consumptionADH1C genotypeLipoprotein levelsAged menCoronary heart diseaseMenopausal statusExogenous estrogenMyocardial infarctionHeart diseaseModerate drinkersOlder menFunctional polymorphismsWomenType 1CMenVaried exposureAssociationHigh levels
2004
Antioxidant vitamins and coronary heart disease risk: a pooled analysis of 9 cohorts 1 2 3
Knekt P, Ritz J, Pereira MA, O'Reilly EJ, Augustsson K, Fraser GE, Goldbourt U, Heitmann BL, Hallmans G, Liu S, Pietinen P, Spiegelman D, Stevens J, Virtamo J, Willett WC, Rimm EB, Ascherio A. Antioxidant vitamins and coronary heart disease risk: a pooled analysis of 9 cohorts 1 2 3. American Journal Of Clinical Nutrition 2004, 80: 1508-1520. PMID: 15585762, DOI: 10.1093/ajcn/80.6.1508.Peer-Reviewed Original ResearchConceptsCoronary heart diseaseSupplemental vitamin C intakeHighest intake quintileVitamin C intakeAntioxidant vitaminsIntake quintilesCHD incidenceCHD riskRelative riskVitamin ECHD eventsC intakeSupplemental vitamin E intakeVitamin C/dCoronary heart disease riskDietary confounding factorsLower CHD incidenceMajor CHD eventsVitamin CIncident CHD eventsHeart disease riskVitamin E intakeSupplemental vitamin CHigh vitamin ECohort studyPhysical activity and risk of coronary heart disease in India
Rastogi T, Vaz M, Spiegelman D, Reddy KS, Bharathi A, Stampfer MJ, Willett WC, Ascherio A. Physical activity and risk of coronary heart disease in India. International Journal Of Epidemiology 2004, 33: 759-767. PMID: 15044412, DOI: 10.1093/ije/dyh042.Peer-Reviewed Original ResearchConceptsLeisure-time exerciseCHD riskRisk factorsPhysical activityPhysical exerciseSedentary activitiesHospital-based case-control studyCoronary heart disease riskDisease riskHeart disease riskCoronary heart diseaseAcute myocardial infarctionRisk of CHDSex-adjusted analysesCase-control studyConditional logistic regressionPhysical inactivity levelsMultivariate adjustmentBrisk walkingMyocardial infarctionHeart diseaseRelative riskSedentary lifestyleElevated riskMultivariate analysis
2003
Vitamin C and risk of coronary heart disease in women
Osganian SK, Stampfer MJ, Rimm E, Spiegelman D, Hu FB, Manson JE, Willett WC. Vitamin C and risk of coronary heart disease in women. Journal Of The American College Of Cardiology 2003, 42: 246-252. PMID: 12875759, DOI: 10.1016/s0735-1097(03)00575-8.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAntioxidantsAscorbic AcidChemopreventionCoronary DiseaseDiabetes ComplicationsDietary SupplementsFemaleHumansHypercholesterolemiaHypertensionIncidenceLife StyleLogistic ModelsMiddle AgedMultivariate AnalysisNutrition SurveysProportional Hazards ModelsProspective StudiesRisk FactorsSmokingSurveys and QuestionnairesUnited StatesWomen's HealthConceptsRisk of CHDCoronary heart diseaseVitamin C intakeCoronary risk factorsVitamin C supplementsC intakeVitamin CC supplementsHeart diseaseRisk factorsLower riskDetailed semiquantitative food frequency questionnaireIncidence of CHDVitamin C supplement useIncident coronary heart diseaseSemiquantitative food frequency questionnaireFood frequency questionnaireSignificant inverse associationIncident casesSupplement useProspective InvestigationInverse associationProtective associationFemale nursesTotal intakeDietary carotenoids and risk of coronary artery disease in women 1 , 2 , 3
Osganian SK, Stampfer MJ, Rimm E, Spiegelman D, Manson JE, Willett WC. Dietary carotenoids and risk of coronary artery disease in women 1 , 2 , 3. American Journal Of Clinical Nutrition 2003, 77: 1390-1399. PMID: 12791615, DOI: 10.1093/ajcn/77.6.1390.Peer-Reviewed Original ResearchConceptsRisk of CADCoronary artery diseaseArtery diseaseHigh intakePrevention of CADIncident coronary artery diseaseSemiquantitative food frequency questionnaireCAD risk factorsBeta-carotene supplementationFood frequency questionnaireCurrent smoking statusDietary carotenoidsSignificant inverse associationLutein/zeaxanthinHigh blood concentrationsConsumption of carotenoidsCAD riskSmoking statusIncident casesHighest quintileLowest quintileInverse associationRisk factorsDietary intakeBlood concentrations
2002
Mercury and the Risk of Coronary Heart Disease in Men
Yoshizawa K, Rimm EB, Morris JS, Spate VL, Hsieh CC, Spiegelman D, Stampfer MJ, Willett WC. Mercury and the Risk of Coronary Heart Disease in Men. New England Journal Of Medicine 2002, 347: 1755-1760. PMID: 12456851, DOI: 10.1056/nejmoa021437.Peer-Reviewed Original ResearchConceptsCoronary heart diseaseHeart diseaseMale health professionalsHigh dietary intakeYears of ageCase-control designMercury levelsSmoking statusTotal mercury exposureControl subjectsLowest quintileRisk factorsDietary intakeCardiovascular diseaseRelative riskCohort membersPrevious historyToenail clippingsHealth professionalsDiseaseConsumption of fishMercury exposureMean mercury levelRiskFish consumption
2001
The effect of fruit and vegetable intake on risk for coronary heart disease.
Joshipura K, Hu F, Manson J, Stampfer M, Rimm E, Speizer F, Colditz G, Ascherio A, Rosner B, Spiegelman D, Willett W. The effect of fruit and vegetable intake on risk for coronary heart disease. Annals Of Internal Medicine 2001, 134: 1106-14. PMID: 11412050, DOI: 10.7326/0003-4819-134-12-200106190-00010.Peer-Reviewed Original ResearchConceptsCoronary heart diseaseHeart diseaseVegetable intakeGreen leafy vegetablesProtective effectHealth StudyVegetable consumptionFatal coronary heart diseaseStandard cardiovascular risk factorsVitamin CCardiovascular risk factorsNonfatal myocardial infarctionNurses' Health StudyProspective cohort studyFood frequency questionnaireIntake of fruitsRich fruitsMain outcome measuresApparent protective effectAssociation of fruitYears of ageConsumption of fruitsEffect of fruitConstituents of fruitsMen 40
2000
Prospective study of major dietary patterns and risk of coronary heart disease in men 1 , 2 , 3
Hu F, Rimm E, Stampfer M, Ascherio A, Spiegelman D, Willett W. Prospective study of major dietary patterns and risk of coronary heart disease in men 1 , 2 , 3. American Journal Of Clinical Nutrition 2000, 72: 912-921. PMID: 11010931, DOI: 10.1093/ajcn/72.4.912.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAlcohol DrinkingBody Mass IndexCohort StudiesCoronary DiseaseDietDiet RecordsDietary SupplementsExerciseFactor Analysis, StatisticalHumansMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionProportional Hazards ModelsProspective StudiesRisk FactorsSmokingSurveys and QuestionnairesConceptsCoronary heart diseaseFood frequency questionnaireMajor dietary patternsRisk of CHDDietary patternsHeart diseaseRelative riskHigh intakePattern scoresCases of CHDHigh-fat dairy productsPrudent pattern scoresWestern pattern scoreCHD risk factorsProspective cohort studyOverall dietary patternsBody mass indexPrudent patternCohort studyCigarette smokingMass indexProspective studyHighest quintileMyocardial infarctionSubgroup analysis
1999
Dietary Fat and Coronary Heart Disease: A Comparison of Approaches for Adjusting for Total Energy Intake and Modeling Repeated Dietary Measurements
Hu F, Stampfer M, Rimm E, Ascherio A, Rosner B, Spiegelman D, Willett W. Dietary Fat and Coronary Heart Disease: A Comparison of Approaches for Adjusting for Total Energy Intake and Modeling Repeated Dietary Measurements. American Journal Of Epidemiology 1999, 149: 531-540. PMID: 10084242, DOI: 10.1093/oxfordjournals.aje.a009849.Peer-Reviewed Original ResearchConceptsCoronary heart diseaseRisk of CHDTotal energy intakeNutrient density modelsBaseline dietHeart diseaseHigh intakeHealth StudyDietary measurementsEnergy intakeMultivariate nutrient density modelsPrevious cohort studiesNurses' Health StudyAssessment of dietEnergy adjustment methodCohort studyEnergy adjustmentFat intakeDietary fatRelative riskRecent dietDietary assessmentIntakeTrans fatsMultivariate model
1996
Dietary fat and risk of coronary heart disease in men: cohort follow up study in the United States
Ascherio A, Rimm E, Giovannucci E, Spiegelman D, Meir S, Willett W. Dietary fat and risk of coronary heart disease in men: cohort follow up study in the United States. The BMJ 1996, 313: 84. PMID: 8688759, PMCID: PMC2351515, DOI: 10.1136/bmj.313.7049.84.Peer-Reviewed Original ResearchConceptsCoronary heart diseaseHeart diseaseMyocardial infarctionFat intakeRisk factorsHealth professionalsFatal coronary heart diseaseNon-dietary risk factorsNon-fatal myocardial infarctionCohort questionnaire studyCoronary risk factorsMultivariate relative riskTotal fat intakeIntake of cholesterolAcute myocardial infarctionDiagnosed cardiovascular diseaseLinolenic acid intakeBlood cholesterol concentrationsIntake of fiberPositive associationCoronary deathCoronary eventsSpecific preventive effectCholesterol intakeCoronary diseaseVegetable, Fruit, and Cereal Fiber Intake and Risk of Coronary Heart Disease Among Men
Rimm EB, Ascherio A, Giovannucci E, Spiegelman D, Stampfer MJ, Willett WC. Vegetable, Fruit, and Cereal Fiber Intake and Risk of Coronary Heart Disease Among Men. JAMA 1996, 275: 447-451. PMID: 8627965, DOI: 10.1001/jama.1996.03530300031036.Peer-Reviewed Original ResearchConceptsTotal myocardial infarctionCoronary heart diseaseDietary fiber intakeMyocardial infarctionFiber intakeRelative riskCoronary diseaseHeart diseaseInverse associationCases of MIAge-adjusted relative riskTotal dietary fiber intakeDietary fiberCereal fiber intakeCardiovascular risk factorsNonfatal myocardial infarctionTotal energy intakeTotal fiber intakeCurrent national dietary guidelinesMain food contributorsFatal coronary diseaseYears of ageNational dietary guidelinesDietary questionnaireCohort studyReproducibility and Validity of a Self-Administered Physical Activity Questionnaire for Male Health Professionals
Chasan-Taber S, Rimm E, Stampfer M, Spiegelman D, Colditz G, Giovannucci E, Ascherio A, Willett W. Reproducibility and Validity of a Self-Administered Physical Activity Questionnaire for Male Health Professionals. Epidemiology 1996, 7: 81-86. PMID: 8664406, DOI: 10.1097/00001648-199601000-00014.Peer-Reviewed Original ResearchConceptsPhysical Activity QuestionnaireActivity QuestionnaireVigorous activityNonvigorous activitiesActivity scoreSelf-administered physical activity questionnaireMale health professionalsParticipants 2 yearsIntraclass correlation coefficientProspective studyHealth professionalsStudy participantsPulse rateActivity diaryStep testWeekly activitiesQuestionnaireDiary measurementsInactivityScoresParticipantsUseful measureActivityParticipants' abilityYears
1995
Body Size and Fat Distribution as Predictors of Coronary Heart Disease among Middle-aged and Older US Men
Rimm E, Stampfer M, Giovannucci E, Ascherio A, Spiegelman D, Colditz G, Willett W. Body Size and Fat Distribution as Predictors of Coronary Heart Disease among Middle-aged and Older US Men. American Journal Of Epidemiology 1995, 141: 1117-1127. PMID: 7771450, DOI: 10.1093/oxfordjournals.aje.a117385.Peer-Reviewed Original ResearchConceptsBody mass indexCoronary heart diseaseHeart diseaseFat distributionMass indexHip ratioProspective studyRisk factorsUS menAge-related hormonal changesIncident coronary heart diseaseLong-term prospective studiesCoronary risk factorsIncident coronary eventsStrong risk factorOlder US menRelative risk estimatesYears of ageCoronary eventsLean menCoronary diseaseObese menIndependent predictorsLong followRelative risk
1992
Correction of Logistic Regression Relative Risk Estimates and Confidence Intervals for Random Within-Person Measurement Error
Rosner B, Spiegelman D, Willett WC. Correction of Logistic Regression Relative Risk Estimates and Confidence Intervals for Random Within-Person Measurement Error. American Journal Of Epidemiology 1992, 136: 1400-1413. PMID: 1488967, DOI: 10.1093/oxfordjournals.aje.a116453.Peer-Reviewed Original ResearchConceptsRelative risk estimatesRisk factorsLogistic regressionRisk estimatesCoronary risk factorsCoronary heart diseaseGold standardConfidence intervalsFramingham Heart StudyExamination 4Extreme quintilesHeart diseaseOdds ratioHeart StudyExamination 2Exposure assessmentSubstudyCovariatesMenMain studyReproducibility dataRegressionFactorsQuintileIncidence