2018
A test for gene–environment interaction in the presence of measurement error in the environmental variable
Aschard H, Spiegelman D, Laville V, Kraft P, Wang M. A test for gene–environment interaction in the presence of measurement error in the environmental variable. Genetic Epidemiology 2018, 42: 250-264. PMID: 29424028, PMCID: PMC5851866, DOI: 10.1002/gepi.22113.Peer-Reviewed Original Research
2011
Socio-economic status, urbanization, and cardiometabolic risk factors among middle-aged adults in Tanzania.
Njelekela MA, Liu E, Mpembeni R, Muhihi A, Mligiliche N, Spiegelman D, Finkelstein JL, Fawzi WW, Willett WC, Mtabaji J. Socio-economic status, urbanization, and cardiometabolic risk factors among middle-aged adults in Tanzania. East African Journal Of Public Health 2011, 8: 216-23. PMID: 23120960.Peer-Reviewed Original ResearchMeSH KeywordsAdultBlood GlucoseBlood PressureBody Mass IndexCardiovascular DiseasesCross-Sectional StudiesDietExerciseFemaleHealth BehaviorHumansLife StyleLipidsLogistic ModelsMaleMetabolic SyndromeMiddle AgedObesityResidence CharacteristicsRisk FactorsSocioeconomic FactorsSurveys and QuestionnairesTanzaniaUrban HealthUrbanizationWaist CircumferenceConceptsCardiometabolic risk factorsPoorer lipid profileHigher socioeconomic statusRisk factorsLipid profileSocioeconomic statusUrban residenceCardio-metabolic risk factorsWorld Health Organization criteriaHigher total cholesterolHigh waist circumferenceRisk of obesityHealth screening strategiesMiddle-aged adultsMetabolic syndromeTotal cholesterolWaist circumferenceLDL cholesterolHigher BMIPrimary preventionLower triglyceridesOrganization criteriaDietary factorsCardiovascular diseaseGlucose levels
2004
Manganese Superoxide Dismutase Polymorphism, Plasma Antioxidants, Cigarette Smoking, and Risk of Breast Cancer
Tamimi RM, Hankinson SE, Spiegelman D, Colditz GA, Hunter DJ. Manganese Superoxide Dismutase Polymorphism, Plasma Antioxidants, Cigarette Smoking, and Risk of Breast Cancer. Cancer Epidemiology Biomarkers & Prevention 2004, 13: 989-996. PMID: 15184255, DOI: 10.1158/1055-9965.989.13.6.Peer-Reviewed Original ResearchConceptsBreast cancer riskHealth Study cohortBreast cancerAla alleleCancer riskCurrent smokersCigarette smokingNurses' Health Study cohortManganese superoxide dismutase polymorphismIndependent risk factorPostmenopausal hormone useCase-control studyVal/ValHormone useStudy cohortIncident casesRisk factorsPlasma antioxidantsDismutase polymorphismAlcohol consumptionVal alleleBlood collectionCancerAntioxidant levelsOxidative stressDiet and risk of ischemic heart disease in India
Rastogi T, Reddy KS, Vaz M, Spiegelman D, Prabhakaran D, Willett WC, Stampfer MJ, Ascherio A. Diet and risk of ischemic heart disease in India. American Journal Of Clinical Nutrition 2004, 79: 582-592. PMID: 15051601, DOI: 10.1093/ajcn/79.4.582.Peer-Reviewed Original ResearchConceptsIschemic heart diseaseServings/wkIHD riskLower riskHeart diseaseInverse associationHospital-based case-control studyDose-dependent inverse associationLong-term dietary intakeFood frequency questionnaireAcute myocardial infarctionCase-control studyConditional logistic regressionPredictors of riskLower relative riskAlpha-linolenic acidBasis of ageMustard oilGreen leafy vegetablesMyocardial infarctionVegetable intakeLeading causeDietary intakeCereal intakeRelative risk
2003
The HRAS1 variable number of tandem repeats and risk of breast cancer.
Tamimi RM, Hankinson SE, Ding S, Gagalang V, Larson GP, Spiegelman D, Colditz GA, Krontiris TG, Hunter DJ. The HRAS1 variable number of tandem repeats and risk of breast cancer. Cancer Epidemiology Biomarkers & Prevention 2003, 12: 1528-30. PMID: 14693748.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAllelesBreast NeoplasmsCase-Control StudiesDNA, NeoplasmFemaleGenes, rasGenetic Predisposition to DiseaseGenotypeHumansLogistic ModelsMiddle AgedMinisatellite RepeatsPolymerase Chain ReactionPolymorphism, GeneticProbabilityPrognosisReference ValuesRisk AssessmentSensitivity and SpecificityTandem Repeat SequencesConceptsHealth Study cohortBreast cancer casesBreast cancerCancer casesNurses' Health Study cohortIncident breast cancer casesHRAS1 VNTRHRAS1 variable numberBreast cancer riskCase-control studyGene-dose effectRare HRAS1 allelesMenopausal statusStudy cohortCancer riskOverall associationCancerHRAS1 allelesRiskRare allelesAssociationCommon allelesAllelesVariable numberCohortVitamin C and risk of coronary heart disease in women
Osganian SK, Stampfer MJ, Rimm E, Spiegelman D, Hu FB, Manson JE, Willett WC. Vitamin C and risk of coronary heart disease in women. Journal Of The American College Of Cardiology 2003, 42: 246-252. PMID: 12875759, DOI: 10.1016/s0735-1097(03)00575-8.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAntioxidantsAscorbic AcidChemopreventionCoronary DiseaseDiabetes ComplicationsDietary SupplementsFemaleHumansHypercholesterolemiaHypertensionIncidenceLife StyleLogistic ModelsMiddle AgedMultivariate AnalysisNutrition SurveysProportional Hazards ModelsProspective StudiesRisk FactorsSmokingSurveys and QuestionnairesUnited StatesWomen's HealthConceptsRisk of CHDCoronary heart diseaseVitamin C intakeCoronary risk factorsVitamin C supplementsC intakeVitamin CC supplementsHeart diseaseRisk factorsLower riskDetailed semiquantitative food frequency questionnaireIncidence of CHDVitamin C supplement useIncident coronary heart diseaseSemiquantitative food frequency questionnaireFood frequency questionnaireSignificant inverse associationIncident casesSupplement useProspective InvestigationInverse associationProtective associationFemale nursesTotal intake
2002
Vitamins and carotenoids intake and the risk of basal cell carcinoma of the skin in women (United States)
Fung TT, Hunter DJ, Spiegelman D, Colditz GA, Speizer FE, Willett WC. Vitamins and carotenoids intake and the risk of basal cell carcinoma of the skin in women (United States). Cancer Causes & Control 2002, 13: 221-230. PMID: 12020103, DOI: 10.1023/a:1015036317596.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge DistributionAscorbic AcidCarcinoma, Basal CellCarotenoidsCohort StudiesConfidence IntervalsDietDietary SupplementsFemaleHumansIncidenceLogistic ModelsMiddle AgedProbabilityProspective StudiesRisk AssessmentSensitivity and SpecificitySkin NeoplasmsUnited StatesVitamin AVitamin EVitaminsConceptsBasal cell carcinomaVitamin ACell carcinomaDietary intakeRelative riskSun sensitivity factorsMultivariate relative riskFood frequency questionnaireRisk of BCCSignificant inverse associationIncidence of BCCImportant protective roleFirst diagnosisDietary factorsInverse associationSun exposureLatency periodProtective roleSpecific carotenoidsLogistic regressionVitamin CBottom quintileIntakeCarcinomaRiskPhysical Activity, Body Mass Index, and Ovulatory Disorder Infertility
Rich-Edwards JW, Spiegelman D, Garland M, Hertzmark E, Hunter DJ, Colditz GA, Willett WC, Wand H, Manson JE. Physical Activity, Body Mass Index, and Ovulatory Disorder Infertility. Epidemiology 2002, 13: 184-190. PMID: 11880759, DOI: 10.1097/00001648-200203000-00013.Peer-Reviewed Original ResearchConceptsBody mass indexOvulatory disorder infertilityHealth Study IIOvulatory infertilityRelative riskMass indexVigorous activityNurses' Health Study IIVigorous-intensity exerciseLower relative riskAmerican womenAdiposity levelsIntensity exercisePhysical activitySedentary lifestyleBMI distributionInfertilityU.S. womenStudy IIWomenUnderweightRiskWeekly activitiesAssociationHours
2000
Prospective Study of Dietary Supplements, Macronutrients, Micronutrients, and Risk of Bladder Cancer in US Men
Michaud DS, Spiegelman D, Clinton SK, Rimm EB, Willett WC, Giovannucci E. Prospective Study of Dietary Supplements, Macronutrients, Micronutrients, and Risk of Bladder Cancer in US Men. American Journal Of Epidemiology 2000, 152: 1145-1153. PMID: 11130620, DOI: 10.1093/aje/152.12.1145.Peer-Reviewed Original ResearchConceptsBladder cancer riskBladder cancerSupplement useBladder carcinogenesisCancer riskTotal vitamin E intakeVitamin C supplement useVitamin E supplement useSuggestive inverse associationFood frequency questionnaireVitamin E intakeFourth leading causeVitamin E supplementsIntake of macroProspective Health ProfessionalsDose-response relationFrequency questionnaireE intakeE supplementsProspective studyInverse associationDietary intakeLeading causeMacronutrient intakeDietary variablesProportion of colon cancer risk that might be preventable in a cohort of middle-aged US men
Platz E, Willett W, Colditz G, Rimm E, Spiegelman D, Giovannucci E. Proportion of colon cancer risk that might be preventable in a cohort of middle-aged US men. Cancer Causes & Control 2000, 11: 579-588. PMID: 10977102, DOI: 10.1023/a:1008999232442.Peer-Reviewed Original ResearchConceptsColon cancer riskMiddle-aged US menRisk factorsCancer riskRisk scoreUS menPopulation attributable risk percentColon cancer risk factorsHealth Professionals FollowModifiable risk factorsAttributable risk percentCancer risk factorsColon cancer incidenceLow-risk scoresRed meat consumptionColon cancer casesLogistic regression modelsProfessionals FollowCigarette smokingColorectal neoplasiaColorectal cancerPhysical inactivityCancer incidenceCancer casesFamily historyEfficient regression calibration for logistic regression in main study/internal validation study designs with an imperfect reference instrument
Spiegelman D, Carroll R, Kipnis V. Efficient regression calibration for logistic regression in main study/internal validation study designs with an imperfect reference instrument. Statistics In Medicine 2000, 20: 139-160. PMID: 11135353, DOI: 10.1002/1097-0258(20010115)20:1<139::aid-sim644>3.0.co;2-k.Peer-Reviewed Original Research
1999
Design of Validation Studies for Estimating the Odds Ratio of Exposure–Disease Relationships When Exposure is Misclassified
Holcroft C, Spiegelman D. Design of Validation Studies for Estimating the Odds Ratio of Exposure–Disease Relationships When Exposure is Misclassified. Biometrics 1999, 55: 1193-1201. PMID: 11315067, DOI: 10.1111/j.0006-341x.1999.01193.x.Peer-Reviewed Original ResearchConceptsOdds ratioGlutathione S -Transferase Mu and Theta Polymorphisms and Breast Cancer Susceptibility
García-Closas M, Kelsey K, Hankinson S, Spiegelman D, Springer K, Willett W, Speizer F, Hunter D. Glutathione S -Transferase Mu and Theta Polymorphisms and Breast Cancer Susceptibility. Journal Of The National Cancer Institute 1999, 91: 1960-1964. PMID: 10564681, DOI: 10.1093/jnci/91.22.1960.Peer-Reviewed Original ResearchConceptsGlutathione S-transferase mu 1Breast cancer riskBreast cancerGSTT1 null genotypeCancer riskOdds ratioNull genotypeGSTT1 genesConditional logistic regression modelsEndogenous mutagenic processesGlutathione S-transferase muConfidence intervalsGSTT1 gene deletionGSTT1 gene polymorphismsLogistic regression modelsHomozygous gene deletionBreast cancer susceptibilityTheta 1 genePremenopausal womenProspective cohortCigarette smokingIncident casesDecreased riskControl subjectsGSTT1 genotypeRecreational Physical Activity and the Risk of Cholecystectomy in Women
Leitzmann M, Rimm E, Willett W, Spiegelman D, Grodstein F, Stampfer M, Colditz G, Giovannucci E. Recreational Physical Activity and the Risk of Cholecystectomy in Women. New England Journal Of Medicine 1999, 341: 777-784. PMID: 10477775, DOI: 10.1056/nejm199909093411101.Peer-Reviewed Original ResearchConceptsRisk of cholecystectomyRecreational physical activityMultivariate relative riskPhysical activityGallstone diseaseRelative riskSedentary behaviorHealth StudyBody weightCases of cholecystectomyRecent weight lossNurses' Health StudyYears of ageSymptomatic cholelithiasisDecreased riskLowest quintileRisk factorsCholecystectomyWeight lossWeight changeWomenDiseaseActivity levelsWeeksRiskRisk Factors for Basal Cell Carcinoma of the Skin in Men: Results from the Health Professionals Follow-up Study
van Dam R, Huang Z, Rimm E, Weinstock M, Spiegelman D, Colditz G, Wiflett W, Giovannucci E. Risk Factors for Basal Cell Carcinoma of the Skin in Men: Results from the Health Professionals Follow-up Study. American Journal Of Epidemiology 1999, 150: 459-468. PMID: 10472945, DOI: 10.1093/oxfordjournals.aje.a010034.Peer-Reviewed Original ResearchConceptsBasal cell carcinomaBCC riskCell carcinomaSun exposureElevated riskUS male health professionalsMale health professionalsHealth Professionals FollowConstitutional factorsRisk of BCCYears of ageRegion of residenceBlistering sunburnsProfessionals FollowProspective cohortRisk factorsNorth European ancestryHealth professionalsLifetime numberCarcinomaRiskMenRed hairEuropean ancestrySkinFruit and Vegetable Intake and Incidence of Bladder Cancer in a Male Prospective Cohort
Michaud D, Spiegelman D, Clinton S, Rimm E, Willett W, Giovannucci E. Fruit and Vegetable Intake and Incidence of Bladder Cancer in a Male Prospective Cohort. Journal Of The National Cancer Institute 1999, 91: 605-613. PMID: 10203279, DOI: 10.1093/jnci/91.7.605.Peer-Reviewed Original ResearchConceptsBladder cancer riskVegetable intakeCancer riskBladder cancerCruciferous vegetablesIndividual cruciferous vegetablesHealth Professionals FollowTotal fruitProspective cohort studyCruciferous vegetable consumptionFood frequency questionnaireCurrent smoking statusIncident bladder cancerPrevious epidemiologic studiesTotal fluid intakeLogistic regression analysisCarotenoid-rich vegetablesProfessionals FollowCohort studyProspective cohortSmoking statusCigarette smokingGreen leafy vegetablesInverse associationFluid intakeSmoking and risk of total and fatal prostate cancer in United States health professionals.
Giovannucci E, Rimm EB, Ascherio A, Colditz GA, Spiegelman D, Stampfer MJ, Willett WC. Smoking and risk of total and fatal prostate cancer in United States health professionals. Cancer Epidemiology Biomarkers & Prevention 1999, 8: 277-82. PMID: 10207628.Peer-Reviewed Original ResearchConceptsFatal prostate cancerProstate cancerCancer incidenceHealth professionalsCumulative smoking historyMale health professionalsSmoking-related comorbiditiesTotal prostate cancerDistant metastatic diseaseProstate cancer incidenceMetastatic prostate cancerRecent tobacco useMetastatic diseaseSmoking historyCigarette smokingLifestyle factorsExcess riskFatal casesTobacco useHigh riskScreening behaviorSmokingCigarette useCancerSmokersRationale and Design of the Tanzania Vitamin and HIV Infection Trial
Fawzi W, Msamanga G, Spiegelman D, Urassa E, Hunter D. Rationale and Design of the Tanzania Vitamin and HIV Infection Trial. Contemporary Clinical Trials 1999, 20: 75-90. PMID: 10027501, DOI: 10.1016/s0197-2456(98)00045-2.Peer-Reviewed Original ResearchConceptsHIV infectionVitamin APregnant womenPolymerase chain reactionVitamin supplementsHIV-positive pregnant womenVertical transmissionHIV Infection TrialInfant immune functionEligible pregnant womenPlacebo-controlled trialClinical staging systemHIV-positive womenGenital tract secretionsUse of supplementsHIV diseaseMost HIVPrevention trialsViral loadMain endpointBreast milkStaging systemCohort retentionPosttest counselingTract secretions
1998
Use of Toenail Fluoride Levels as an Indicator for the Risk of Hip and Forearm Fractures in Women
Feskanich D, Owusu W, Hunter D, Willett W, Ascherio A, Spiegelman D, Morris S, Spate V, Colditz G. Use of Toenail Fluoride Levels as an Indicator for the Risk of Hip and Forearm Fractures in Women. Epidemiology 1998, 9: 412-416. PMID: 9647905, DOI: 10.1097/00001648-199807000-00011.Peer-Reviewed Original ResearchConceptsForearm fracturesFluoride intakeOdds ratioHealth StudyVitamin D intakeDistal forearm fracturesNurses' Health StudyRisk of hipPostmenopausal hormone useBody mass indexLong-term intakeYear of birthD intakeMenopausal statusHip fractureHormone useHighest quartileMass indexOsteoporotic fracturesSmoking statusPrevious hipHeart diseaseSubsequent riskCaffeine intakeEpidemiologic studies
1997
Variation in the incidence of uterine leiomyoma among premenopausal women by age and race.
Marshall LM, Spiegelman D, Barbieri RL, Goldman MB, Manson JE, Colditz GA, Willett WC, Hunter DJ. Variation in the incidence of uterine leiomyoma among premenopausal women by age and race. Obstetrics And Gynecology 1997, 90: 967-73. PMID: 9397113, DOI: 10.1016/s0029-7844(97)00534-6.Peer-Reviewed Original ResearchConceptsUterine leiomyomaRelative riskPremenopausal womenRisk factorsIncidence rateFirst oral contraceptive useWhite womenBlack womenOral contraceptive useBody mass indexHistory of infertilityPremenopausal black womenSimilar relative riskPotential risk factorsSelf-reported diagnosisAge-standardized ratesCurrent alcohol consumptionRace-specific ratesMass indexPhysical examinationPelvic examinationMedical recordsHigh prevalenceContraceptive useLast birth