2010
Lipid-soluble vitamins A, D, and E in HIV-infected pregnant women in Tanzania
Mehta S, Spiegelman D, Aboud S, Giovannucci EL, Msamanga GI, Hertzmark E, Mugusi FM, Hunter DJ, Fawzi WW. Lipid-soluble vitamins A, D, and E in HIV-infected pregnant women in Tanzania. European Journal Of Clinical Nutrition 2010, 64: 808-817. PMID: 20517330, PMCID: PMC3078753, DOI: 10.1038/ejcn.2010.76.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnemia, Iron-DeficiencyAvitaminosisBlood SedimentationCD8-Positive T-LymphocytesCell CountDietFemaleGestational AgeHemoglobinsHIV InfectionsHumansNutritional StatusPregnancyPrevalenceRegression AnalysisSeleniumTanzaniaVitamin AVitamin A DeficiencyVitamin DVitamin D DeficiencyVitamin EVitamin E DeficiencyYoung AdultConceptsErythrocyte sedimentation rateVitamin E statusPregnant womenLipid-soluble vitaminsVitamin APlasma vitaminGestational ageLow vitaminE statusLow vitamin D statusHigh erythrocyte sedimentation rateLow vitamin E statusLipid-soluble vitamins ACD8 cell countsVitamin D statusHuman immunodeficiency virusPlasma vitamin EPoor nutritional statusPlasma vitamin ALow plasma vitamin AResource-limited settingsD statusLaboratory parametersImmunodeficiency virusSevere anemia
2004
Antioxidant vitamins and coronary heart disease risk: a pooled analysis of 9 cohorts 1 2 3
Knekt P, Ritz J, Pereira MA, O'Reilly EJ, Augustsson K, Fraser GE, Goldbourt U, Heitmann BL, Hallmans G, Liu S, Pietinen P, Spiegelman D, Stevens J, Virtamo J, Willett WC, Rimm EB, Ascherio A. Antioxidant vitamins and coronary heart disease risk: a pooled analysis of 9 cohorts 1 2 3. American Journal Of Clinical Nutrition 2004, 80: 1508-1520. PMID: 15585762, DOI: 10.1093/ajcn/80.6.1508.Peer-Reviewed Original ResearchConceptsCoronary heart diseaseSupplemental vitamin C intakeHighest intake quintileVitamin C intakeAntioxidant vitaminsIntake quintilesCHD incidenceCHD riskRelative riskVitamin ECHD eventsC intakeSupplemental vitamin E intakeVitamin C/dCoronary heart disease riskDietary confounding factorsLower CHD incidenceMajor CHD eventsVitamin CIncident CHD eventsHeart disease riskVitamin E intakeSupplemental vitamin CHigh vitamin ECohort studySelenium Status Is Associated with Accelerated HIV Disease Progression among HIV-1–Infected Pregnant Women in Tanzania
Kupka R, Msamanga GI, Spiegelman D, Morris S, Mugusi F, Hunter DJ, Fawzi WW. Selenium Status Is Associated with Accelerated HIV Disease Progression among HIV-1–Infected Pregnant Women in Tanzania. Journal Of Nutrition 2004, 134: 2556-2560. PMID: 15465747, DOI: 10.1093/jn/134.10.2556.Peer-Reviewed Original ResearchConceptsPlasma selenium levelsCD4 cell countRisk of mortalityDisease progressionHIV-1-infected pregnant womenCell countSelenium levelsLow plasma selenium levelsHIV disease progressionAccelerated disease progressionCox multivariate modelSelenium statusMedian followHIV diseaseClinical outcomesPregnant womenPoor survivalTanzanian womenMultivariate modelL increaseCells/ProgressionWomenMortalityFirst yearEffect of Prenatal Vitamin Supplementation on Lower-Genital Levels of HIV Type 1 and Interleukin Type 1β at 36 Weeks of Gestation
Fawzi W, Msamanga G, Antelman G, Xu C, Hertzmark E, Spiegelman D, Hunter D, Anderson D. Effect of Prenatal Vitamin Supplementation on Lower-Genital Levels of HIV Type 1 and Interleukin Type 1β at 36 Weeks of Gestation. Clinical Infectious Diseases 2004, 38: 716-722. PMID: 14986257, DOI: 10.1086/381673.Peer-Reviewed Original ResearchConceptsHIV-1HIV-1-infected pregnant womenVitamin AHIV-1-infected womenType 1Human immunodeficiency virus type 1Immunodeficiency virus type 1Genital HIV-1Prenatal multivitamin supplementsHIV-1 transmissionCervicovaginal lavage specimensHIV Type 1HIV-1 infectionLower genital tractWeeks of gestationPrenatal vitamin supplementationUse of vitaminsVirus type 1Lack of effectPregnancy outcomesVaginal inflammationViral sheddingVitamin supplementationMultivitamin supplementsPregnant women
2003
Dietary Fiber Reduces Peripheral Arterial Disease Risk in Men
Merchant AT, Hu FB, Spiegelman D, Willett WC, Rimm EB, Ascherio A. Dietary Fiber Reduces Peripheral Arterial Disease Risk in Men. Journal Of Nutrition 2003, 133: 3658-3663. PMID: 14608090, DOI: 10.1093/jn/133.11.3658.Peer-Reviewed Original ResearchConceptsPeripheral arterial disease riskCereal fiber intakeArterial disease riskPAD riskFiber intakeInverse associationDisease riskEarly coronary heart diseaseIncident PAD casesFood frequency questionnaireCoronary heart diseaseTotal fiber intakeOverall inverse associationDisease QuestionnaireFrequency questionnaireLowest quintileHeart diseaseCardiovascular diseaseFamily historyPhysical activityPAD casesAlcohol consumptionEnergy intakeIntakeRiskPremenopausal intakes of vitamins A, C, and E, folate, and carotenoids, and risk of breast cancer.
Cho E, Spiegelman D, Hunter DJ, Chen WY, Zhang SM, Colditz GA, Willett WC. Premenopausal intakes of vitamins A, C, and E, folate, and carotenoids, and risk of breast cancer. Cancer Epidemiology Biomarkers & Prevention 2003, 12: 713-20. PMID: 12917201.Peer-Reviewed Original ResearchConceptsHealth Study IIBreast cancer riskBreast cancerVitamin ACancer riskNurses' Health Study IIMultivariate relative riskFood frequency questionnaireInvasive breast cancerPrevious epidemiological studiesEarly adult lifePostmenopausal womenPremenopausal womenIncident casesHighest quintileLowest quintileRelative riskHigh intakeEpidemiological studiesNutrient intakeTotal vitaminCancerStudy IIIntakeVitamin C
2002
Vitamin and carotenoid intake and risk of squamous cell carcinoma of the skin
Fung TT, Spiegelman D, Egan KM, Giovannucci E, Hunter DJ, Willett WC. Vitamin and carotenoid intake and risk of squamous cell carcinoma of the skin. International Journal Of Cancer 2002, 103: 110-115. PMID: 12455062, DOI: 10.1002/ijc.10798.Peer-Reviewed Original ResearchConceptsCases of SCCHEALTHY studyProspective cohort study designMale health professionalsHealth Professionals FollowCohort study designIntake of vitaminsSquamous cell carcinomaSignificant inverse associationDevelopment of SCCImportant protective roleIncidence of SCCBiennial questionnairesProfessionals FollowMultivariate adjustmentCell carcinomaSCC incidenceDietary factorsInverse associationMedical recordsRisk factorsRelative riskLarge cohortCarotenoid intakeSun exposureIntakes of vitamins E and C, carotenoids, vitamin supplements, and PD risk
Zhang SM, Hernán MA, Chen H, Spiegelman D, Willett WC, Ascherio A. Intakes of vitamins E and C, carotenoids, vitamin supplements, and PD risk. Neurology 2002, 59: 1161-1169. PMID: 12391343, DOI: 10.1212/01.wnl.0000028688.75881.12.Peer-Reviewed Original ResearchConceptsRisk of PDVitamin E intakeVitamin EHigh intakeVitamin supplementsE intakeRelative riskHealth StudyHigher dietary vitamin E intakeHigh vitamin E intakePooled multivariate relative risksDietary vitamin E intakeSemiquantitative food frequency questionnaireMultivariate relative riskIncident PD casesNurses' Health StudyFood frequency questionnaireDietary vitamin CDietary vitamin EVitamin C supplementsPathogenesis of PDConsumption of nutsFrequency questionnaireConstituents of foodsHighest quintileVitamins and carotenoids intake and the risk of basal cell carcinoma of the skin in women (United States)
Fung TT, Hunter DJ, Spiegelman D, Colditz GA, Speizer FE, Willett WC. Vitamins and carotenoids intake and the risk of basal cell carcinoma of the skin in women (United States). Cancer Causes & Control 2002, 13: 221-230. PMID: 12020103, DOI: 10.1023/a:1015036317596.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge DistributionAscorbic AcidCarcinoma, Basal CellCarotenoidsCohort StudiesConfidence IntervalsDietDietary SupplementsFemaleHumansIncidenceLogistic ModelsMiddle AgedProbabilityProspective StudiesRisk AssessmentSensitivity and SpecificitySkin NeoplasmsUnited StatesVitamin AVitamin EVitaminsConceptsBasal cell carcinomaVitamin ACell carcinomaDietary intakeRelative riskSun sensitivity factorsMultivariate relative riskFood frequency questionnaireRisk of BCCSignificant inverse associationIncidence of BCCImportant protective roleFirst diagnosisDietary factorsInverse associationSun exposureLatency periodProtective roleSpecific carotenoidsLogistic regressionVitamin CBottom quintileIntakeCarcinomaRisk
2001
Population-based study of α- and γ-tocopherol in plasma and adipose tissue as biomarkers of intake in Costa Rican adults 1 , 2 , 3
El-Sohemy A, Baylin A, Ascherio A, Kabagambe E, Spiegelman D, Campos H. Population-based study of α- and γ-tocopherol in plasma and adipose tissue as biomarkers of intake in Costa Rican adults 1 , 2 , 3. American Journal Of Clinical Nutrition 2001, 74: 356-363. PMID: 11522560, DOI: 10.1093/ajcn/74.3.356.Peer-Reviewed Original ResearchConceptsAlpha-tocopherol intakeBiomarkers of intakeAdipose tissueGamma-tocopherolTissue concentrationsAlpha-tocopherolGamma-tocopherol intakeFood frequency questionnairePopulation-based studyDietary alpha-tocopherolAlpha-tocopherol concentrationsGamma-tocopherol concentrationsTissue biopsy samplesSupplement useVitamin supplementsBlood samplesBiopsy samplesVitamin EGood biomarkerUS dietSuitable biomarkersIntakePalm shorteningBiomarkersAdults 1Intakes of carotenoids, vitamin C, and vitamin E and MS risk among two large cohorts of women
Zhang SM, Hernán MA, Olek MJ, Spiegelman D, Willett WC, Ascherio A. Intakes of carotenoids, vitamin C, and vitamin E and MS risk among two large cohorts of women. Neurology 2001, 57: 75-80. PMID: 11445631, DOI: 10.1212/wnl.57.1.75.Peer-Reviewed Original ResearchConceptsRisk of MSVitamin EVitamin CLarge cohortSemiquantitative food frequency questionnaireRecent case-control studyAssociation of intakeMultivariate relative riskVitamin C intakeFood frequency questionnaireIntake of carotenoidsIntake of fruitsDietary vitamin CTotal energy intakeDietary vitamin E.Case-control studyLutein/zeaxanthinCases of MSFrequency questionnaireC intakeMS riskMultivitamin supplementsAntioxidant nutrientsHighest quintileLowest quintile
1998
Vitamins A, C and E and the risk of breast cancer: results from a case-control study in Greece
Bohlke K, Spiegelman D, Trichopoulou A, Katsouyanni K, Trichopoulos D. Vitamins A, C and E and the risk of breast cancer: results from a case-control study in Greece. British Journal Of Cancer 1998, 79: 23-29. PMID: 10408688, PMCID: PMC2362172, DOI: 10.1038/sj.bjc.6690006.Peer-Reviewed Original ResearchConceptsΒ-carotene intakeBreast cancer riskCase-control studyBreast cancerOdds ratioCancer riskVitamin ESemiquantitative food frequency questionnaireBreast cancer risk factorsIntake of retinolVitamin CFood frequency questionnaireCancer risk factorsPost-menopausal womenTotal energy intakeΒ-carotene effectPremenopausal womenFrequency questionnaireControl womenVegetable intakeInverse associationRisk factorsDietary compoundsDietary dataSpecific micronutrients
1994
Human adiposeα-tocopherol andγ-tocopherol kinetics during and after 1 y ofα-tocopherol supplementation
Handelman G, Epstein W, Peerson J, Spiegelman D, Machlin L, Dratz E. Human adiposeα-tocopherol andγ-tocopherol kinetics during and after 1 y ofα-tocopherol supplementation. American Journal Of Clinical Nutrition 1994, 59: 1025-1032. PMID: 8172086, DOI: 10.1093/ajcn/59.5.1025.Peer-Reviewed Original ResearchConceptsAlpha-tocopherol intakeAlpha-tocopherolGamma-tocopherolTocopherol/dLong-term useSupplement useTocopherol ratioNeedle biopsySupplementation periodSupplementation trialTocopherol supplementCross-sectional measurementsHuman AdiposeAdditional yearIntakeSupplementationConsistent decreaseSupplementsSubjectsBiopsyGammaTrials