2020
The Moderate Alcohol and Cardiovascular Health Trial (MACH15): Design and methods for a randomized trial of moderate alcohol consumption and cardiometabolic risk
Spiegelman D, Lovato LC, Khudyakov P, Wilkens TL, Adebamowo CA, Adebamowo SN, Appel LJ, Beulens JW, Coughlin JW, Dragsted LO, Edenberg HJ, Eriksen JN, Estruch R, Grobbee DE, Gulayin PE, Irazola V, Krystal JH, Lazo M, Murray MM, Rimm EB, Schrieks IC, Williamson JD, Mukamal KJ. The Moderate Alcohol and Cardiovascular Health Trial (MACH15): Design and methods for a randomized trial of moderate alcohol consumption and cardiometabolic risk. European Journal Of Preventive Cardiology 2020, 27: 1967-1982. PMID: 32250171, PMCID: PMC7541556, DOI: 10.1177/2047487320912376.Peer-Reviewed Original ResearchConceptsModerate alcohol consumptionCardiovascular Health TrialAlcohol consumptionHealth trialsCardiovascular diseaseModerate alcoholNon-fatal ischemic strokeNon-fatal myocardial infarctionPrimary composite endpointCongestive heart failureCoronary heart diseaseModerate alcohol consumersAdults 50 yearsPublic health guidelinesAlcohol use disorderPreferred alcoholic beverageCardiometabolic effectsCardiometabolic riskCarotid revascularizationIschemic strokeSecondary outcomesComposite endpointHeart failurePrimary outcomeMyocardial infarctionWorksite intervention study to prevent diabetes in Nepal: a randomised trial protocol
Pyakurel P, Shrestha A, Karmacharya BM, Budhathoki SS, Chaudhari RK, Tamrakar D, Shrestha A, Karmacharya RM, Shrestha A, Sharma S, Sharma SK, Spiegelman D. Worksite intervention study to prevent diabetes in Nepal: a randomised trial protocol. Open Heart 2020, 7: e001236. PMID: 32847993, PMCID: PMC7451278, DOI: 10.1136/openhrt-2019-001236.Peer-Reviewed Original ResearchMeSH KeywordsAdultBiomarkersBlood GlucoseDiabetes MellitusGlycated HemoglobinHealth BehaviorHealth Knowledge, Attitudes, PracticeHealthy LifestyleHumansMaleMiddle AgedMulticenter Studies as TopicNepalOccupational Health ServicesPatient Education as TopicPrediabetic StatePrimary PreventionRandomized Controlled Trials as TopicRisk Reduction BehaviorTime FactorsTreatment OutcomeConceptsBehavioral interventionsControl periodDiabetes risk reductionMonth control periodNepal Health Research CouncilBehavioral intervention groupWorksite intervention studiesT-testHealth Research CouncilInstitutional review boardTwo-sample t-testBlood sugarTrial protocolIntervention groupEthical approvalControl groupIntervention studiesType 2More monthsReview boardInterventionDiabetesParticipant changesPublic healthRisk reduction
2011
Predictors of change in nutritional and hemoglobin status among adults treated for tuberculosis in Tanzania
Kawai K, Villamor E, Mugusi FM, Saathoff E, Urassa W, Bosch RJ, Spiegelman D, Fawzi WW. Predictors of change in nutritional and hemoglobin status among adults treated for tuberculosis in Tanzania. The International Journal Of Tuberculosis And Lung Disease 2011, 15: 1380-1389. PMID: 22283899, PMCID: PMC3404808, DOI: 10.5588/ijtld.10.0784.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnemiaAntitubercular AgentsBiomarkersBody Mass IndexCoinfectionFemaleHealth Status IndicatorsHemoglobinsHIV InfectionsHumansLinear ModelsMaleMalnutritionMultivariate AnalysisNutritional StatusNutritional SupportProspective StudiesTanzaniaTime FactorsTreatment OutcomeTuberculosis, PulmonaryYoung AdultConceptsLow CD4 cell countsHuman immunodeficiency virusBody mass indexCD4 cell countHIV-positive patientsTB treatmentCell countPredictors of changeTB patientsHemoglobin statusHIV-negative TB patientsHIV-positive TB patientsOlder ageHIV-negative adultsHIV-negative patientsPrevious TB infectionHIV-negative participantsAdequate nutritional supportHigh viral loadProfound malnutritionTB infectionPulmonary tuberculosisNutritional recoveryNutritional supportHemoglobin levels
2009
Power and sample size calculations for longitudinal studies comparing rates of change with a time‐varying exposure
Basagaña X, Spiegelman D. Power and sample size calculations for longitudinal studies comparing rates of change with a time‐varying exposure. Statistics In Medicine 2009, 29: 181-192. PMID: 19899065, PMCID: PMC3772653, DOI: 10.1002/sim.3772.Peer-Reviewed Original Research
2005
Dietary flavonols and flavonol‐rich foods intake and the risk of breast cancer
Adebamowo CA, Cho E, Sampson L, Katan MB, Spiegelman D, Willett WC, Holmes MD. Dietary flavonols and flavonol‐rich foods intake and the risk of breast cancer. International Journal Of Cancer 2005, 114: 628-633. PMID: 15609322, DOI: 10.1002/ijc.20741.Peer-Reviewed Original ResearchConceptsMultivariate relative riskBreast cancer riskCumulative average intakeFlavonol-rich foodsIntake of beansRelative riskBreast cancerCancer riskFlavonol intakeLowest quintileInverse associationDietary flavonolsAverage intakeNurses' Health Study IIIntake of flavonolsHealth Study IIFood frequency questionnaireInvasive breast cancerSignificant inverse associationFrequency questionnaireEpidemiological studiesAnimal studiesDietary dataOverall associationFurther evaluationReply to TV Chacko et al
Rastogi T, Reddy K, Vaz M, Spiegelman D, Prabhakaran D, Willett W, Stampfer M, Ascherio A. Reply to TV Chacko et al. American Journal Of Clinical Nutrition 2005, 81: 537. PMID: 15699248, DOI: 10.1093/ajcn.81.2.537.Peer-Reviewed Original Research
2004
Sexual Orientation, Health Risk Factors, and Physical Functioning in the Nurses' Health Study II
Case P, Austin SB, Hunter DJ, Manson JE, Malspeis S, Willett WC, Spiegelman D. Sexual Orientation, Health Risk Factors, and Physical Functioning in the Nurses' Health Study II. Journal Of Women's Health 2004, 13: 1033-1047. PMID: 15665660, DOI: 10.1089/jwh.2004.13.1033.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcohol DrinkingBisexualityBody Mass IndexBreast NeoplasmsCardiovascular DiseasesCross-Sectional StudiesDepressionFemaleHealth BehaviorHealth StatusHomosexuality, FemaleHumansLinear ModelsMental HealthMiddle AgedMultivariate AnalysisNurse CliniciansPrevalenceProspective StudiesRisk FactorsSmokingTime FactorsUnited StatesConceptsNurses' Health Study IIHealth Study IIBody mass indexRisk factorsHealth risk factorsHigh prevalenceRegion of residenceOverall cohortBreast cancerHealth statusHigher daily alcohol intakeCardiovascular disease risk factorsBreast cancer risk factorsHigher body mass indexStudy IIMultivariate prevalence ratiosDaily alcohol intakeDisease risk factorsUse of antidepressantsCancer risk factorsHealth-related functioningImportant risk factorMental health statusPoor mental healthBisexual women
2003
Use of Complementary and Alternative Therapies by Patients With Human Immunodeficiency Virus Disease in the Era of Highly Active Antiretroviral Therapy
Bica I, Tang AM, Skinner S, Spiegelman D, Knox T, Gorbach S, Wilson IB. Use of Complementary and Alternative Therapies by Patients With Human Immunodeficiency Virus Disease in the Era of Highly Active Antiretroviral Therapy. Journal Of Alternative And Complementary Medicine 2003, 9: 65-76. PMID: 12676036, DOI: 10.1089/107555303321222955.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusActive antiretroviral therapyCAM useAntiretroviral therapyHighly Active Antiretroviral TherapyHuman immunodeficiency virus (HIV) diseaseCAM therapy useHealthy Living StudyPotential drug interactionsUse of ComplementaryLow-risk groupAlternative medical therapiesEffective drug treatmentCross-sectional analysisLeast high schoolHAART useCohort studyMale patientsMedical therapyTherapy useImmunodeficiency virusComplementary therapiesAlternative therapiesStudy visitRisk groups
2001
Application of the Method of Triads to Evaluate the Performance of Food Frequency Questionnaires and Biomarkers as Indicators of Long-term Dietary Intake
Kabagambe EK, Baylin A, Allan DA, Siles X, Spiegelman D, Campos H. Application of the Method of Triads to Evaluate the Performance of Food Frequency Questionnaires and Biomarkers as Indicators of Long-term Dietary Intake. American Journal Of Epidemiology 2001, 154: 1126-1135. PMID: 11744518, DOI: 10.1093/aje/154.12.1126.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueBiomarkersCarotenoidsCosta RicaEpidemiologic Research DesignFactor Analysis, StatisticalFatty AcidsFatty Acids, UnsaturatedFemaleHumansLycopeneMaleMental RecallMiddle AgedMinority GroupsNutrition SurveysReproducibility of ResultsSensitivity and SpecificitySurveys and QuestionnairesTime FactorsTocopherolsConceptsFood frequency questionnaireDietary intakeMethod of triadsFrequency questionnaireDietary recallsAdipose tissueLong-term dietary intakeFatty acidsUS minority groupsSuperior biomarkerPoor biomarkerTissue samplesBiomarkersIntakeMedian validity coefficientsTissueValidity coefficientsQuestionnaireSubjectsPast yearPlasmaTocopherolsWomen
2000
Oral contraceptives and the incidence of multiple sclerosis
Hernán M, Hohol MJ, Olek MJ, Spiegelman D, Ascherio A. Oral contraceptives and the incidence of multiple sclerosis. Neurology 2000, 55: 848-853. PMID: 10994007, DOI: 10.1212/wnl.55.6.848.Peer-Reviewed Original ResearchConceptsRisk of MSHealth Study IIOral contraceptive useOral contraceptivesContraceptive useProtective effectHealth StudyNurses' Health Study IIAge-adjusted relative riskOral contraceptive historiesNurses' Health StudyProgression of MSDiagnosis of MSDuration of useCohort studyMS incidenceMS riskHormonal contraceptionMultiple sclerosisContraceptive historyRelative riskClinical dataProbable casesU.S. womenPast users
1999
Reproducibility of plasma and urinary sex hormone levels in premenopausal women over a one-year period.
Michaud DS, Manson JE, Spiegelman D, Barbieri RL, Sepkovic DW, Bradlow HL, Hankinson SE. Reproducibility of plasma and urinary sex hormone levels in premenopausal women over a one-year period. Cancer Epidemiology Biomarkers & Prevention 1999, 8: 1059-64. PMID: 10613337.Peer-Reviewed Original ResearchConceptsPremenopausal womenIntraclass correlation coefficientLuteal phaseHormone levelsBlood samplesEndogenous sex steroid hormonesUrinary sex hormone levelsUrinary sex hormonesUrinary estrogen metabolitesSex hormone levelsSex steroid hormonesSets of bloodSingle blood sampleHigh intraclass correlation coefficientsLuteal phase samplesPlasma estrogenMenstrual cycleSex hormonesPlasma estradiolBreast cancerEstrogen metabolitesEstrone sulfateUrinary 2One-year periodSteroid hormones
1998
A prospective study of physical activity and prostate cancer in male health professionals.
Giovannucci E, Leitzmann M, Spiegelman D, Rimm EB, Colditz GA, Stampfer MJ, Willett WC. A prospective study of physical activity and prostate cancer in male health professionals. Cancer Research 1998, 58: 5117-22. PMID: 9823321.Peer-Reviewed Original ResearchConceptsMale health professionalsTotal prostate cancerMetastatic prostate cancerProstate cancerPhysical activityMetabolic equivalentsVigorous activityLower riskHealth professionalsLeisure-time physical activityMore metabolic equivalentsNonvigorous physical activityReported average timeHealth Professionals FollowHistory of diabetesProspective cohort studyAdvanced prostate cancerRole of exerciseTime physical activityYears of ageWarrants further studyNonvigorous activitiesMen 40Professionals FollowCohort studyPlasma Sex Steroid Hormone Levels and Risk of Breast Cancer in Postmenopausal Women
Hankinson S, Willett W, Manson J, Colditz G, Hunter D, Spiegelman D, Barbieri R, Speizer F. Plasma Sex Steroid Hormone Levels and Risk of Breast Cancer in Postmenopausal Women. Journal Of The National Cancer Institute 1998, 90: 1292-1299. PMID: 9731736, DOI: 10.1093/jnci/90.17.1292.Peer-Reviewed Original ResearchConceptsSex steroid hormone levelsHormone replacement therapyBreast cancer riskPostmenopausal womenBreast cancerSteroid hormone levelsBlood collectionEstrogen levelsReplacement therapyHormone levelsCancer riskHealth StudyPrevious hormone replacement therapyPlasma sex steroid hormone levelsPostmenopausal estrogen levelsNurses' Health StudyPlasma estrogen levelsLevels of estradiolCase-control studyPlasma androgen levelsBioavailable estradiolMenopausal statusSignificant positive associationControl subjectsLowest quartile
1997
Oral Contraceptives and Ovulatory Causes of Delayed Fertility
Chasan-Taber L, Willett W, Stampfer M, Spiegelman D, Rosner B, Hunter D, Colditz G, Manson J. Oral Contraceptives and Ovulatory Causes of Delayed Fertility. American Journal Of Epidemiology 1997, 146: 258-265. PMID: 9247010, DOI: 10.1093/oxfordjournals.aje.a009261.Peer-Reviewed Original ResearchConceptsOvulatory causeOral contraceptivesMultivariate relative riskOral contraceptive useReturn of fertilityHistory of infertilityCase-control studyPercent of casesDuration of useMethod of contraceptionOvulatory infertilityPrevious pregnancyEventual pregnancyHormonal disordersRelative riskContraceptive useYounger agePregnancyMarried nursesNursesWomenContraceptivesInfertilityDelayed fertilityFirst use