2012
Elevated alanine aminotransferase in antiretroviral‐naïve HIV‐infected African patients: magnitude and risk factors
Nagu T, Kanyangarara M, Hawkins C, Hertmark E, Chalamila G, Spiegelman D, Mugusi F, Fawzi W. Elevated alanine aminotransferase in antiretroviral‐naïve HIV‐infected African patients: magnitude and risk factors. HIV Medicine 2012, 13: 541-548. PMID: 22416813, PMCID: PMC3391335, DOI: 10.1111/j.1468-1293.2012.01006.x.Peer-Reviewed Original ResearchConceptsElevated alanine aminotransferaseIU/LAlanine aminotransferaseAntiretroviral therapyHigh riskWorld Health Organization clinical stageCD4 T-lymphocyte countFirst-line antiretroviral therapyHepatitis B virus coinfectionALT measurementsLow-density lipoprotein cholesterolLog-binomial regression modelsB virus coinfectionT-lymphocyte countsART-naïve HIVCells/μLHepatotoxic side effectsCurrent tuberculosis (TB) treatmentResource-limited settingsCross-sectional analysisAdvanced immunosuppressionHBV coinfectionART-naïveHIV careLipoprotein cholesterol
2004
Understanding the Role of HIV Load in Determining Weight Change in the Era of Highly Active Antiretroviral Therapy
Mwamburi DM, Wilson IB, Jacobson DL, Spiegelman D, Gorbach SL, Knox TA, Wanke CA. Understanding the Role of HIV Load in Determining Weight Change in the Era of Highly Active Antiretroviral Therapy. Clinical Infectious Diseases 2004, 40: 167-173. PMID: 15614708, DOI: 10.1086/426591.Peer-Reviewed Original ResearchConceptsActive antiretroviral therapyVirus loadBody weightAntiretroviral therapyHIV infectionWeight changeStudy visitHuman immunodeficiency virus RNA loadHighly Active Antiretroviral TherapyAbsence of HAARTProspective cohort studyCell count decreaseVirus RNA loadTime of enrollmentStudy intervalRepeated-measures analysisHIV loadHAART useCohort studyRNA loadHAARTPatientsEligible sampleCell countCount decrease
2002
Correlates of Plasma HIV-1 RNA Viral Load Among HIV-1 Seropositive Women in Dar es Salaam, Tanzania
Kapiga SH, Bang H, Spiegelman D, Msamanga GI, Coley J, Hunter DJ, Fawzi WW. Correlates of Plasma HIV-1 RNA Viral Load Among HIV-1 Seropositive Women in Dar es Salaam, Tanzania. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2002, 30: 316-323. PMID: 12131569, DOI: 10.1097/01.qai.0000014767.47046.c8.Peer-Reviewed Original ResearchConceptsHIV-1 RNA viral loadRNA viral loadPlasma HIV-1 RNA viral loadViral loadCopies/mLLymphocyte countHIV-1 positive pregnant womenHIV-1-seropositive womenMedian viral loadHigh viral loadPrevention of malariaTime of deliverySeropositive womenAbsolute CD4Pregnant womenClinical trialsHIV-1Long-term effectsDaily food expenditureMalaria parasitesBaselineMonthsDar es SalaamCD4Food expenditure
2001
Assessment of Markers of Hepatitis C Virus Infection in a Japanese Adult Population
Arduino J, Stuver S, Spiegelman D, Okayama A, Tabor E, Yu M, Kohara M, Tsubouchi H, Mueller N. Assessment of Markers of Hepatitis C Virus Infection in a Japanese Adult Population. The Journal Of Infectious Diseases 2001, 184: 1229-1235. PMID: 11679910, DOI: 10.1086/324006.Peer-Reviewed Original ResearchConceptsHepatitis C virus infectionC virus infectionHCV core proteinHCV infectionHCV RNAVirus infectionCommunity-based Japanese populationCurrent HCV infectionHCV infection statusLatent class analysisJapanese adult populationLogistic regression analysisAssessment of markersUsefulness of markersVirus markersCore proteinAdult populationInfectionInfection statusSerum samplesJapanese populationHCVRegression analysisDemographic factorsMarkersDo HIV Type 1 RNA Levels Provide Additional Prognostic Value to CD4+ T Lymphocyte Counts in Patients with Advanced HIV Type 1 Infection?
Arduino J, Fischl M, Stanley K, Collier A, Spiegelman D. Do HIV Type 1 RNA Levels Provide Additional Prognostic Value to CD4+ T Lymphocyte Counts in Patients with Advanced HIV Type 1 Infection? AIDS Research And Human Retroviruses 2001, 17: 1099-1105. PMID: 11522179, DOI: 10.1089/088922201316912709.Peer-Reviewed Original ResearchConceptsHIV-1 RNA levelsHIV-1 disease progressionBaseline HIV-1 RNA levelsT-lymphocyte countsT lymphocytesDisease progressionLymphocyte countRNA levelsCells/Prognostic informationHigh baseline HIV-1 RNA levelsHIV type 1 RNA levelsPlasma HIV-1 RNA levelsSubsequent HIV-1 disease progressionAdvanced HIV-1 diseaseHIV Type 1 InfectionConditional logistic regression analysisDisease progression independentHIV-1 diseaseAdditional prognostic informationAdditional prognostic valueType 1 infectionCase-control studyLogistic regression analysisClinical statusPredictors of intrauterine and intrapartum transmission of HIV-1 among Tanzanian women
Fawzi W, Msamanga G, Renjifo B, Spiegelman D, Urassa E, Hashemi L, Antelman G, Essex M, Hunter D. Predictors of intrauterine and intrapartum transmission of HIV-1 among Tanzanian women. AIDS 2001, 15: 1157-1165. PMID: 11416718, DOI: 10.1097/00002030-200106150-00011.Peer-Reviewed Original ResearchConceptsViral loadHIV-1HIV-1-infected pregnant womenLower genital tract infectionMaternal CD4 cell countVertical transmissionLower genital infectionsMaternal viral loadCD4 cell countGenital tract infectionHIV disease progressionHIV-1 infectionWeeks of gestationPrevention of transmissionIntrapartum transmissionIntrauterine transmissionGenital infectionTract infectionsSustained clearanceClinical stagePregnant womenPrenatal careDisease progressionCopies/Vitamin supplements
1999
Elevated resting energy expenditure among HIV-seropositive persons receiving highly active antiretroviral therapy
Shevitz A, Knox T, Spiegelman D, Roubenoff R, Gorbach S, Skolnik P. Elevated resting energy expenditure among HIV-seropositive persons receiving highly active antiretroviral therapy. AIDS 1999, 13: 1351-1357. PMID: 10449288, DOI: 10.1097/00002030-199907300-00012.Peer-Reviewed Original ResearchConceptsFat-free massActive antiretroviral therapyHAART useHIV RNAAntiretroviral therapyCohort studyViral burdenKJ/dayHIV-seropositive menCD4 cell countHIV-seropositive personsLog10 copies/Energy expenditureLarge cohort studyIndependent effectsCross-sectional analysisHIV diseaseMedication regimensViral loadCopies/Adjusted REECell countElevated REEViral replicationHAART