2004
Manganese Superoxide Dismutase Polymorphism, Plasma Antioxidants, Cigarette Smoking, and Risk of Breast Cancer
Tamimi RM, Hankinson SE, Spiegelman D, Colditz GA, Hunter DJ. Manganese Superoxide Dismutase Polymorphism, Plasma Antioxidants, Cigarette Smoking, and Risk of Breast Cancer. Cancer Epidemiology Biomarkers & Prevention 2004, 13: 989-996. PMID: 15184255, DOI: 10.1158/1055-9965.989.13.6.Peer-Reviewed Original ResearchConceptsBreast cancer riskHealth Study cohortBreast cancerAla alleleCancer riskCurrent smokersCigarette smokingNurses' Health Study cohortManganese superoxide dismutase polymorphismIndependent risk factorPostmenopausal hormone useCase-control studyVal/ValHormone useStudy cohortIncident casesRisk factorsPlasma antioxidantsDismutase polymorphismAlcohol consumptionVal alleleBlood collectionCancerAntioxidant levelsOxidative stress
2003
The HRAS1 variable number of tandem repeats and risk of breast cancer.
Tamimi RM, Hankinson SE, Ding S, Gagalang V, Larson GP, Spiegelman D, Colditz GA, Krontiris TG, Hunter DJ. The HRAS1 variable number of tandem repeats and risk of breast cancer. Cancer Epidemiology Biomarkers & Prevention 2003, 12: 1528-30. PMID: 14693748.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAllelesBreast NeoplasmsCase-Control StudiesDNA, NeoplasmFemaleGenes, rasGenetic Predisposition to DiseaseGenotypeHumansLogistic ModelsMiddle AgedMinisatellite RepeatsPolymerase Chain ReactionPolymorphism, GeneticProbabilityPrognosisReference ValuesRisk AssessmentSensitivity and SpecificityTandem Repeat SequencesConceptsHealth Study cohortBreast cancer casesBreast cancerCancer casesNurses' Health Study cohortIncident breast cancer casesHRAS1 VNTRHRAS1 variable numberBreast cancer riskCase-control studyGene-dose effectRare HRAS1 allelesMenopausal statusStudy cohortCancer riskOverall associationCancerHRAS1 allelesRiskRare allelesAssociationCommon allelesAllelesVariable numberCohort
2002
The androgen receptor CAG repeat polymorphism and risk of breast cancer in the Nurses' Health Study.
Haiman CA, Brown M, Hankinson SE, Spiegelman D, Colditz GA, Willett WC, Kantoff PW, Hunter DJ. The androgen receptor CAG repeat polymorphism and risk of breast cancer in the Nurses' Health Study. Cancer Research 2002, 62: 1045-9. PMID: 11861380.Peer-Reviewed Original ResearchConceptsFirst-degree family historyBreast cancer riskHealth Study cohortAndrogen receptorBreast cancerCancer riskFamily historyAR genotypeCaucasian womenHormone levelsHealth StudyNurses' Health Study cohortBreast cancer risk factorsEndogenous steroid hormone levelsNurses' Health StudyCancer risk factorsPostmenopausal Caucasian womenCase-control studyAndrogen receptor genotypeAndrogen receptor CAGAndrogen receptor allelesSteroid hormone levelsShort alleleLong alleleSignificant positive associationNo association between a single nucleotide polymorphism in CYP19 and breast cancer risk.
Haiman CA, Hankinson SE, Spiegelman D, Brown M, Hunter DJ. No association between a single nucleotide polymorphism in CYP19 and breast cancer risk. Cancer Epidemiology Biomarkers & Prevention 2002, 11: 215-6. PMID: 11867511.Peer-Reviewed Original Research
2001
Association of genetic polymorphisms in UGT1A1 with breast cancer and plasma hormone levels.
Guillemette C, De Vivo I, Hankinson SE, Haiman CA, Spiegelman D, Housman DE, Hunter DJ. Association of genetic polymorphisms in UGT1A1 with breast cancer and plasma hormone levels. Cancer Epidemiology Biomarkers & Prevention 2001, 10: 711-4. PMID: 11401924.Peer-Reviewed Original ResearchConceptsHealth Study cohortBreast cancer riskHormone levelsBreast cancerUGT1A1 genotypeCancer riskNurses' Health Study cohortPremenopausal breast cancer riskUDP-glucuronosyltransferasesBody mass indexCase-control studyPlasma hormone levelsUGT1A1 promoter polymorphismCommon insertion/deletion polymorphismInsertion/deletion polymorphismPostmenopausal womenHormone replacementMass indexStudy cohortEstradiol levelsEstradiol metabolismBlood drawCaucasian womenRelative riskAfrican American population
2000
A prospective study of the effect of alcohol consumption and ADH3 genotype on plasma steroid hormone levels and breast cancer risk.
Hines LM, Hankinson SE, Smith-Warner SA, Spiegelman D, Kelsey KT, Colditz GA, Willett WC, Hunter DJ. A prospective study of the effect of alcohol consumption and ADH3 genotype on plasma steroid hormone levels and breast cancer risk. Cancer Epidemiology Biomarkers & Prevention 2000, 9: 1099-105. PMID: 11045794.Peer-Reviewed Original ResearchConceptsBreast cancer riskAlcohol dehydrogenase type 3Hormone levelsCancer riskSteroid hormone levelsAlcohol intakeAlcohol consumptionADH3 genotypeHealth StudyADH3 polymorphismIncident breast cancer casesSex hormone-binding globulinOverall breast cancer riskPlasma steroid hormone levelsNurses' Health StudyHormone-binding globulinPartial Pearson correlation coefficientsCase-control studyConditional logistic regressionBreast cancer casesPostmenopausal womenProspective studyDehydroepiandrosterone sulfateRelative riskBreast cancerPolymorphic repeat in AIB1 does not alter breast cancer risk
Haiman C, Hankinson S, Spiegelman D, Colditz G, Willett W, Speizer F, Brown M, Hunter D. Polymorphic repeat in AIB1 does not alter breast cancer risk. Breast Cancer Research 2000, 2: 378. PMID: 11056690, PMCID: PMC13920, DOI: 10.1186/bcr82.Peer-Reviewed Original ResearchConceptsBreast cancer riskHealth Study cohortCancer riskPostmenopausal breast cancer riskNurses' Health Study cohortBreast cancer incidenceCase-control studySpecific tumor characteristicsAIB1 genotypeStudy cohortTumor characteristicsCancer incidenceCaucasian womenGeneral populationAIB1Repeat polymorphismRiskAssociationCohortIncidenceGenotypesWomenA tetranucleotide repeat polymorphism in CYP19 and breast cancer risk
Haiman C, Hankinson S, Spiegelman D, De Vivo I, Colditz G, Willett W, Speizer F, Hunter D. A tetranucleotide repeat polymorphism in CYP19 and breast cancer risk. International Journal Of Cancer 2000, 87: 204-210. PMID: 10861475, DOI: 10.1002/1097-0215(20000715)87:2<204::aid-ijc8>3.0.co;2-3.Peer-Reviewed Original ResearchConceptsBreast cancer riskHealth Study cohortCase-control studyCancer riskHormone levelsNurses' Health Study cohortBreast cancer case-control studyElevated estrogen levelsAdvanced cancer casesCancer case-control studyRepeat polymorphismTetranucleotide repeat polymorphismConversion of androgensGreater frequencyKey steroidogenic enzymesSignificant greater frequencyDistant metastasisStudy cohortEstrogen levelsCYP19 allelesBreast cancerCancer casesAllele carriersEstrone sulfateNonsignificant increase
1999
Glutathione S -Transferase Mu and Theta Polymorphisms and Breast Cancer Susceptibility
García-Closas M, Kelsey K, Hankinson S, Spiegelman D, Springer K, Willett W, Speizer F, Hunter D. Glutathione S -Transferase Mu and Theta Polymorphisms and Breast Cancer Susceptibility. Journal Of The National Cancer Institute 1999, 91: 1960-1964. PMID: 10564681, DOI: 10.1093/jnci/91.22.1960.Peer-Reviewed Original ResearchConceptsGlutathione S-transferase mu 1Breast cancer riskBreast cancerGSTT1 null genotypeCancer riskOdds ratioNull genotypeGSTT1 genesConditional logistic regression modelsEndogenous mutagenic processesGlutathione S-transferase muConfidence intervalsGSTT1 gene deletionGSTT1 gene polymorphismsLogistic regression modelsHomozygous gene deletionBreast cancer susceptibilityTheta 1 genePremenopausal womenProspective cohortCigarette smokingIncident casesDecreased riskControl subjectsGSTT1 genotypeThe relationship between a polymorphism in CYP17 with plasma hormone levels and breast cancer.
Haiman CA, Hankinson SE, Spiegelman D, Colditz GA, Willett WC, Speizer FE, Kelsey KT, Hunter DJ. The relationship between a polymorphism in CYP17 with plasma hormone levels and breast cancer. Cancer Research 1999, 59: 1015-20. PMID: 10070957.Peer-Reviewed Original ResearchConceptsHealth Study cohortBreast cancer riskBreast cancerHormone levelsA2 alleleCancer riskNurses' Health Study cohortStrong independent risk factorA2/A2 genotypeCYP17 A2 alleleElevated levelsAdvanced breast cancerIncident breast cancerIndependent risk factorPolycystic ovarian syndromeCertain steroid hormonesA1/A1 genotypeCase-control studyPlasma hormone levelsSteroid hormone levelsLater agePremenopausal womenCYP17 genotypeHormone replacementOvarian syndromeN‐acetyl transferase 2 genotypes, meat intake and breast cancer risk
Gertig D, Hankinson S, Hough H, Spiegelman D, Colditz G, Willett W, Kelsey K, Hunter D. N‐acetyl transferase 2 genotypes, meat intake and breast cancer risk. International Journal Of Cancer 1999, 80: 13-17. PMID: 9935222, DOI: 10.1002/(sici)1097-0215(19990105)80:1<13::aid-ijc3>3.0.co;2-w.Peer-Reviewed Original ResearchConceptsBreast cancer riskRed meat intakeMeat intakeRapid acetylatorsBreast cancerSlow acetylatorsCancer riskHealth StudyLow red meat intakeHigh red meat intakeNurses' Health StudyHeterocyclic aminesLack of associationHigh-temperature cooking methodsFrequent intakeNAT2 genotypeBlood drawAcetylator genotypeBlood samplesAcetylatorsSignificant associationCancerIntakeMajor causeHuman carcinogenesis
1998
A prospective study of methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms, and risk of colorectal adenoma.
Chen J, Giovannucci E, Hankinson SE, Ma J, Willett WC, Spiegelman D, Kelsey KT, Hunter DJ. A prospective study of methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms, and risk of colorectal adenoma. Carcinogenesis 1998, 19: 2129-2132. PMID: 9886567, DOI: 10.1093/carcin/19.12.2129.Peer-Reviewed Original ResearchConceptsVal/Val polymorphismColorectal adenomasMethylenetetrahydrofolate reductase (MTHFR) geneHealth StudyProspective Nurses' Health StudyNurses' Health StudyRisk of adenomaVal polymorphismSynthase gene polymorphismsMethionine synthase geneLack of associationPolyp casesProspective studyColorectal cancerGly polymorphismBenign adenomasGene polymorphismsAdenomasColorectal tumorigenesisMalignant transformationFunctional polymorphismsMethylenetetrahydrofolate reductaseMethionine synthase gene polymorphismsRiskPolymorphismCigarette smoking, cytochrome P450 1A1 polymorphisms, and breast cancer risk in the Nurses' Health Study.
Ishibe N, Hankinson SE, Colditz GA, Spiegelman D, Willett WC, Speizer FE, Kelsey KT, Hunter DJ. Cigarette smoking, cytochrome P450 1A1 polymorphisms, and breast cancer risk in the Nurses' Health Study. Cancer Research 1998, 58: 667-71. PMID: 9485019.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsBreast NeoplasmsCase-Control StudiesCytochrome P-450 CYP1A1FemaleHumansMiddle AgedPolymorphism, GeneticProspective StudiesRiskSmokingConceptsBreast cancer riskNurses' Health StudyCigarette smokingBreast cancerCancer riskHealth StudyAryl hydrocarbon hydroxylase activityRelative riskCYP1A1 polymorphismsIncident breast cancer casesHydroxylase activityVariant CYP1A1 genotypesBreast cancer ratesBreast cancer incidenceConfidence intervalsCytochrome P450 1A1 (CYP1A1) polymorphismsCase-control studyConditional logistic regressionBreast cancer casesExon 7 polymorphismHomozygous wild typeSusceptible womenModifiable causesCancer incidenceCaucasian women
1997
Glutathione S-transferase class mu deletion polymorphism and breast cancer: results from prevalent versus incident cases.
Kelsey KT, Hankinson SE, Colditz GA, Springer K, Garcia-Closas M, Spiegelman D, Manson JE, Garland M, Stampfer MJ, Willett WC, Speizer FE, Hunter DJ. Glutathione S-transferase class mu deletion polymorphism and breast cancer: results from prevalent versus incident cases. Cancer Epidemiology Biomarkers & Prevention 1997, 6: 511-5. PMID: 9232338.Peer-Reviewed Original ResearchConceptsBreast cancerGene deletion polymorphismCase seriesDeletion polymorphismHealth StudyNull genotypeGSTM1 deletionGlutathione S-transferase class muPrevalent breast cancerIncident breast cancerNurses' Health StudyGSTM1 gene deletion polymorphismBreast cancer riskDuration of survivalAge-matched controlsGSTM1 null genotypeBreast cancer prognosisMolecular epidemiologic studiesImproved survivalCigarette smokingIncident casesOdds ratioPrevalent casesEpidemiologic studiesCancer risk
1996
A methylenetetrahydrofolate reductase polymorphism and the risk of colorectal cancer.
Chen J, Giovannucci E, Kelsey K, Rimm EB, Stampfer MJ, Colditz GA, Spiegelman D, Willett WC, Hunter DJ. A methylenetetrahydrofolate reductase polymorphism and the risk of colorectal cancer. Cancer Research 1996, 56: 4862-4. PMID: 8895734.Peer-Reviewed Original ResearchConceptsVal/Val individualsVal/Val genotypeColorectal cancerOdds ratioVal genotypeHealth Professionals FollowColorectal cancer riskStrong risk factorHigh dietary intakeCase-control studyMore alcoholic drinksMethylenetetrahydrofolate reductase (MTHFR) polymorphismsVariant homozygous genotypeMethylenetetrahydrofolate reductase (MTHFR) geneProfessionals FollowAlcohol intakeInverse associationRisk factorsDietary intakeReduced incidenceMTHFR genotypeCancer riskBlood samplesAlcohol consumptionOncogenic alterations