2005
Selenium levels in relation to morbidity and mortality among children born to HIV-infected mothers
Kupka R, Msamanga GI, Spiegelman D, Rifai N, Hunter DJ, Fawzi WW. Selenium levels in relation to morbidity and mortality among children born to HIV-infected mothers. European Journal Of Clinical Nutrition 2005, 59: 1250-1258. PMID: 16015252, DOI: 10.1038/sj.ejcn.1602236.Peer-Reviewed Original ResearchConceptsPlasma selenium levelsMorbidity informationSelenium levelsChild mortalityMaternal vitamin supplementsMonthly clinic visitsProspective cohort studyTertiary care hospitalMuhimbili National HospitalRisk of diarrheaChild health outcomesMonths of ageSelenium statusCause mortalityClinic visitsCohort studyRespiratory outcomesMedian ageStudy clinicNational HospitalVitamin supplementsHealth outcomesStudy childrenFogarty International CenterStudy participants
2003
The Use of B Vitamin Supplements and Peripheral Arterial Disease Risk in Men Are Inversely Related
Merchant AT, Hu FB, Spiegelman D, Willett WC, Rimm EB, Ascherio A. The Use of B Vitamin Supplements and Peripheral Arterial Disease Risk in Men Are Inversely Related. Journal Of Nutrition 2003, 133: 2863-2867. PMID: 12949378, DOI: 10.1093/jn/133.9.2863.Peer-Reviewed Original ResearchConceptsPeripheral arterial diseasePAD riskFolate intakePrevention of PADPeripheral arterial disease riskVitamin BArterial disease riskIncident PAD casesU.S. health professionalsB vitamin intakeVitamin supplement useB-vitamin supplementsCoronary heart diseaseWeak inverse associationMultivariate adjustmentArterial diseaseVitamin intakeSupplement useHeart diseaseInverse associationCardiovascular diseaseD incrementStudy populationVitamin supplementsDietary folateEffect of Providing Vitamin Supplements to Human Immunodeficiency Virus-Infected, Lactating Mothers on the Child's Morbidity and CD4+ Cell Counts
Fawzi WW, Msamanga GI, Wei R, Spiegelman D, Antelman G, Villamor E, Manji K, Hunter D. Effect of Providing Vitamin Supplements to Human Immunodeficiency Virus-Infected, Lactating Mothers on the Child's Morbidity and CD4+ Cell Counts. Clinical Infectious Diseases 2003, 36: 1053-1062. PMID: 12684919, DOI: 10.1086/374223.Peer-Reviewed Original ResearchConceptsMultivitamin armCell countVitamin AHuman immunodeficiency virus type 1Immunodeficiency virus type 1Placebo-controlled trialCells/microLHIV-negative childrenHIV-positive childrenHuman immunodeficiency virusChildren of womenRapid respiratory rateVirus type 1Low-cost interventionEffect of supplementationMaternal receiptMean CD4Immunodeficiency virusMultivitamin supplementsChild morbidityChild healthVitamin supplementsLower riskRespiratory rateType 1
2002
Intakes of vitamins E and C, carotenoids, vitamin supplements, and PD risk
Zhang SM, Hernán MA, Chen H, Spiegelman D, Willett WC, Ascherio A. Intakes of vitamins E and C, carotenoids, vitamin supplements, and PD risk. Neurology 2002, 59: 1161-1169. PMID: 12391343, DOI: 10.1212/01.wnl.0000028688.75881.12.Peer-Reviewed Original ResearchConceptsRisk of PDVitamin E intakeVitamin EHigh intakeVitamin supplementsE intakeRelative riskHealth StudyHigher dietary vitamin E intakeHigh vitamin E intakePooled multivariate relative risksDietary vitamin E intakeSemiquantitative food frequency questionnaireMultivariate relative riskIncident PD casesNurses' Health StudyFood frequency questionnaireDietary vitamin CDietary vitamin EVitamin C supplementsPathogenesis of PDConsumption of nutsFrequency questionnaireConstituents of foodsHighest quintileRandomized trial of vitamin supplements in relation to transmission of HIV-1 through breastfeeding and early child mortality
Fawzi WW, Msamanga GI, Hunter D, Renjifo B, Antelman G, Bang H, Manji K, Kapiga S, Mwakagile D, Essex M, Spiegelman D. Randomized trial of vitamin supplements in relation to transmission of HIV-1 through breastfeeding and early child mortality. AIDS 2002, 16: 1935-1944. PMID: 12351954, DOI: 10.1097/00002030-200209270-00011.Peer-Reviewed Original ResearchConceptsHIV-1 transmissionInfants of mothersVitamin ALower baseline lymphocyte countsHigh erythrocyte sedimentation rateChild mortalityBaseline lymphocyte countMaternal micronutrient statusHIV-free survivalErythrocyte sedimentation rateLow birthweight babiesEarly child mortalityRisk of transmissionLymphocyte countLower hemoglobinMultivitamin supplementationWeeks' gestationBirthweight babiesPregnant womenHIV-1Vitamin supplementsMultivitaminsNutritional statusMicronutrient statusMortality
2001
Population-based study of α- and γ-tocopherol in plasma and adipose tissue as biomarkers of intake in Costa Rican adults 1 , 2 , 3
El-Sohemy A, Baylin A, Ascherio A, Kabagambe E, Spiegelman D, Campos H. Population-based study of α- and γ-tocopherol in plasma and adipose tissue as biomarkers of intake in Costa Rican adults 1 , 2 , 3. American Journal Of Clinical Nutrition 2001, 74: 356-363. PMID: 11522560, DOI: 10.1093/ajcn/74.3.356.Peer-Reviewed Original ResearchConceptsAlpha-tocopherol intakeBiomarkers of intakeAdipose tissueGamma-tocopherolTissue concentrationsAlpha-tocopherolGamma-tocopherol intakeFood frequency questionnairePopulation-based studyDietary alpha-tocopherolAlpha-tocopherol concentrationsGamma-tocopherol concentrationsTissue biopsy samplesSupplement useVitamin supplementsBlood samplesBiopsy samplesVitamin EGood biomarkerUS dietSuitable biomarkersIntakePalm shorteningBiomarkersAdults 1Predictors of intrauterine and intrapartum transmission of HIV-1 among Tanzanian women
Fawzi W, Msamanga G, Renjifo B, Spiegelman D, Urassa E, Hashemi L, Antelman G, Essex M, Hunter D. Predictors of intrauterine and intrapartum transmission of HIV-1 among Tanzanian women. AIDS 2001, 15: 1157-1165. PMID: 11416718, DOI: 10.1097/00002030-200106150-00011.Peer-Reviewed Original ResearchConceptsViral loadHIV-1HIV-1-infected pregnant womenLower genital tract infectionMaternal CD4 cell countVertical transmissionLower genital infectionsMaternal viral loadCD4 cell countGenital tract infectionHIV disease progressionHIV-1 infectionWeeks of gestationPrevention of transmissionIntrapartum transmissionIntrauterine transmissionGenital infectionTract infectionsSustained clearanceClinical stagePregnant womenPrenatal careDisease progressionCopies/Vitamin supplements
1999
Rationale and Design of the Tanzania Vitamin and HIV Infection Trial
Fawzi W, Msamanga G, Spiegelman D, Urassa E, Hunter D. Rationale and Design of the Tanzania Vitamin and HIV Infection Trial. Contemporary Clinical Trials 1999, 20: 75-90. PMID: 10027501, DOI: 10.1016/s0197-2456(98)00045-2.Peer-Reviewed Original ResearchConceptsHIV infectionVitamin APregnant womenPolymerase chain reactionVitamin supplementsHIV-positive pregnant womenVertical transmissionHIV Infection TrialInfant immune functionEligible pregnant womenPlacebo-controlled trialClinical staging systemHIV-positive womenGenital tract secretionsUse of supplementsHIV diseaseMost HIVPrevention trialsViral loadMain endpointBreast milkStaging systemCohort retentionPosttest counselingTract secretions