A prospective study of methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms, and risk of colorectal adenoma.
Chen J, Giovannucci E, Hankinson SE, Ma J, Willett WC, Spiegelman D, Kelsey KT, Hunter DJ. A prospective study of methylenetetrahydrofolate reductase and methionine synthase gene polymorphisms, and risk of colorectal adenoma. Carcinogenesis 1998, 19: 2129-2132. PMID: 9886567, DOI: 10.1093/carcin/19.12.2129.Peer-Reviewed Original ResearchConceptsVal/Val polymorphismColorectal adenomasMethylenetetrahydrofolate reductase (MTHFR) geneHealth StudyProspective Nurses' Health StudyNurses' Health StudyRisk of adenomaVal polymorphismSynthase gene polymorphismsMethionine synthase geneLack of associationPolyp casesProspective studyColorectal cancerGly polymorphismBenign adenomasGene polymorphismsAdenomasColorectal tumorigenesisMalignant transformationFunctional polymorphismsMethylenetetrahydrofolate reductaseMethionine synthase gene polymorphismsRiskPolymorphism